Results 141 to 150 of about 7,200 (169)

ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein

Biochemical and Biophysical Research Communications, 2004
The zinc finger antiviral protein (ZAP) is a recently isolated host antiviral factor. It specifically inhibits the replication of Moloney murine leukemia virus (MMLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm.
Lixin, Liu, Guifang, Chen, Xin, Ji, Guangxia, Gao   +3 more
openaire   +2 more sources

Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors

Journal of Medicinal Chemistry, 2023
Cancer cells frequently utilize elevated nuclear export to escape tumor suppression and gain proliferative advantage. Chromosome Region Maintenance 1 (CRM1/XPO1) mediates macromolecule nuclear export and plays an important role in tumorigenesis and progression.
Lunan Jian, Robert Zscherp, Ulrike Beutling, Xiaofei Shen, Shiyang Xu, Xia Zhang, Mark Brönstrup, Philipp Klahn, Qingxiang Sun   +8 more
openaire   +2 more sources

CRM1 mediates the nuclear export of YTHDF2

Biochemical and Biophysical Research Communications
Precise intracellular localization is crucial for protein function. YTHDF2, a reader protein for N6-methyladenosine (m6A), has been reported to shuttle between the cytoplasm and nucleus through an unknown mechanism. Here, we identify a functional nuclear export sequence (NES) in YTHDF2 that mediates its nuclear export.
Shumei Wei, Ye Wang, Jiaqi Cao, Jinyu Hou, Chuangao Xie, Xiang-Wei Gao   +5 more
openaire   +2 more sources

Regulation of Crm1 expression in cancer cells

Clinical Cancer Research, 2010
Abstract Crm1 (or exportin 1) is a member of the karyopherin β protein family that mediates the nuclear export of cargo proteins and certain RNAs from the nucleus into the cytoplasm. We previously identified increased expression of Crm1 mRNA and protein in cervical tumours compared to normal epithelium, and increased Crm1 expression in ...
Pauline J. van der Watt, Virna D. Leaner
openaire   +1 more source

CRM1 as a new therapeutic target for non-Hodgkin lymphoma

Leukemia Research, 2015
The chromosomal region maintenance 1 (CRM1) may serve as a novel target for cancer treatment. Here, we investigated the anti non-Hodgkin lymphoma (NHL) activity of two novel CRM1 inhibitors (KPT-185 and KPT-276) in vitro and in vivo. KPT-185 displayed potent antiproliferative properties and induced cell-cycle arrest and apoptosis in several NHL cell ...
Yuankai Shi, Xiaohong Han, Jiarui Yao
exaly   +3 more sources

Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection

Current Cancer Drug Targets, 2015
The integrity of eukaryotic cellular function depends on molecular and biochemical compartmentalization. The transport of macromolecules between compartments requires specific and energydriven mechanisms. It occurs through a class of transport proteins known as karyopherins, which are divided in three different groups (exportins, importins, and ...
Chuanwen, Lu, Jose A, Figueroa, Zhongwei, Liu, Venu, Konala, Amardeep, Aulakh, Rashmi, Verma, Everardo, Cobos, Maurizio, Chiriva-Internati, Weimin, Gao   +8 more
openaire   +2 more sources

Analysis of CRM1-Dependent Nuclear Export in Permeabilized Cells

2016
Nuclear protein import and export assays in permeabilized cells have been instrumental for the identification of transport factors and for the molecular characterization of nucleocytoplasmic transport pathways. Our original assay to quantitatively analyze CRM1-dependent export was based on stably transfected cells expressing GFP-NFAT.
Ralph H, Kehlenbach, Sarah A, Port
openaire   +2 more sources

Crm1 is a mitotic effector of Ran-GTP in somatic cells

Nature Cell Biology, 2005
The Ran GTPase controls multiple cellular processes, including nuclear transport, mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. Here we examine the mitotic function of Crm1, the Ran-GTP-binding nuclear export receptor for leucine-rich cargo (bearing nuclear export sequence) and Snurportin-1 (ref. 3).
Alexei, Arnaoutov, Yoshiaki, Azuma, Katharina, Ribbeck, Jomon, Joseph, Yekaterina, Boyarchuk, Tatiana, Karpova, James, McNally, Mary, Dasso   +7 more
openaire   +2 more sources

CRM1 mediates ASC nuclear export and inflammasome activation

International Immunopharmacology
Inflammasomes are multiprotein complexes of the innate immune system that sense different pathogens or danger signals, and have been implicated in the pathogenesis of multiple human inflammatory diseases. The translocation of adaptor protein ASC from the nucleus to the cytosol is important for inflammasome assembly and activation, but the mechanism ...
Rui, Cao, Bolong, Lin, Hongbin, He, Di, Wang, Xiaqiong, Wang, Yi, Huang, Rongbin, Zhou   +6 more
openaire   +2 more sources

CRM1

2018
openaire   +1 more source