Results 101 to 110 of about 18,104 (240)

RNA Nuclear Export: From Neurological Disorders to Cancer [PDF]

, 2017
The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place ...
Hautbergue, G.M.
core   +1 more source

The karyopherin CRM1 is required for dendritic cell maturation

Immunobiology, 2010
Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz, Nadine, Turza, Ilona, Hauber, Alexander, Steinkasserer, Joachim, Hauber   +4 more
openaire   +2 more sources

The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress [PDF]

, 2014
This article is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.Guanine nucleotide exchange factors control many aspects of cell morphogenesis by turning on Rho-GTPases.
García, Patricia, Manjón, Elvira, Muñoz, Sofía, Sunnerhagen, Per, Sánchez, Yolanda   +4 more
core   +2 more sources

The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.

PLoS ONE, 2015
The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha, Progga Sen, Sarita Raghunayakula, Xiang-Dong Zhang   +3 more
doaj   +1 more source

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements

bioRxiv, 2020
Chromosomal translocations fusing the locus of nucleoporin NUP214 each with the proto-oncogenes SET and DEK are recurrent in, largely intractable, acute leukemias.
A. Mendes, Ramona Jühlen, V. Martinelli, B. Fahrenkrog   +3 more
semanticscholar   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

CRM1 inhibitor anti-tumor activity is enhanced with salicylates by S-phase arrest and impaired DNA-damage repair.

Blood, 2020
Chromosome region maintenance protein1 (CRM1) mediates protein export from the nucleus and is a new target for anti-cancer therapeutics. Broader application of KPT-330 (selinexor), a first in class CRM1 inhibitor recently approved for relapsed multiple ...
J. Abeykoon, Xiaosheng Wu, K. Nowakowski, S. Dasari, J. Paludo, S. Weroha, Chunling Hu, X. Hou, J. Sarkaria, A. Mladek, J. L. Phillips, A. Feldman, A. Ravindran, R. King, Justin C Boysen, M. Stenson, Ryan M. Carr, M. Manske, J. R. Molina, P. Kapoor, S. Parikh, Shaji K. Kumar, Steven I. Robinson, Jia Yu, J. Boughey, Liewei Wang, M. Goetz, F. Couch, M. Patnaik, T. Witzig   +29 more
semanticscholar   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source

Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]

, 2017
The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra, Leonardi, Emanuela, Murgia, Alessandra, Tosatto, Silvio C. E.   +3 more
core   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source