Results 51 to 60 of about 9,261 (202)
Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Nature Communications, 2021 Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal ...
Annika Meiners +14 more
doaj +1 more source
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
doaj +1 more source
PLoS ONE, 2020 The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear ...
Catherine P Lavau +7 more
doaj +1 more source
The karyopherin CRM1 is required for dendritic cell maturation
Immunobiology, 2010 Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz +4 more
openaire +2 more sources
Atomic basis of CRM1-cargo recognition, release and inhibition [PDF]
Seminars in Cancer Biology, 2014 CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug target as the transport receptor is overexpressed in many cancers where some of its cargos are misregulated and mislocalized to the cytoplasm.
Ho Yee Joyce, Fung, Yuh Min, Chook
openaire +2 more sources
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family
, 2012 The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences).
Bañuelos Rodríguez, Sonia +2 more
core +1 more source
PLoS Biology, 2020 In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu +5 more
doaj +1 more source
Untersuchung des CRM1-abhängigen RNA-Exports mittels Repräsentativer Differenz-Analyse [PDF]
, 2004 Der Kern-/Cytoplasma-Transport von Proteinen und RNA-Protein-Komplexen durch die Kernpore wird von Transport-Rezeptoren der Importin beta-Familie vermittelt.
Schütz, Sylvia
core +1 more source
CRM1 active sites and corresponding binding sites.
, 2023 Calculated locations of CRM1 binding and interactions with each of the three selected proteins. (DOCX)
Mohammad Habibur Rahman Molla (13902168) +13 more
core +1 more source
Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source