Results 51 to 60 of about 18,104 (240)
C-terminal Sequences Direct Cyclin D1-CRM1 Binding [PDF]
Journal of Biological Chemistry, 2004 GSK-3beta-dependent phosphorylation of cyclin D1 at a conserved C-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export. Herein, we have identified a short stretch of residues adjacent to Thr-286 that mediates CRM1 association and thus cyclin D1 nuclear export.
Sharon, Benzeno, J Alan, Diehl
openaire +2 more sources
The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA
eLife, 2014 The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions.
David S Booth +2 more
doaj +1 more source
The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]
, 2008 Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan +3 more
core +2 more sources
CRM1-Dependent Trafficking of Retroviral Gag Proteins Revisited [PDF]
Journal of Virology, 2012 ABSTRACT We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV). Surprisingly,
Mariju F, Baluyot +4 more
openaire +2 more sources
Journal of Cell Science, 2021 Nup214 is a major nucleoporin on the cytoplasmic side of the nuclear pore complex with roles in late steps of nuclear protein and mRNA export. It interacts with the nuclear export receptor CRM1 (also known as XPO1) via characteristic phenylalanine ...
M. Hamed +3 more
semanticscholar +1 more source
Antileukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells [PDF]
, 2012 Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects.
Barcelo, C +15 more
core +1 more source
Traffic : the International Journal of Intracellular Transport, 2021 Dysregulation of the nuclear export machinery mediated by chromosomal maintenance 1 (CRM1, also known as exportin‐1), is closely associated with various human disorders, such as breast cancer.
Jiujiao Gao +5 more
semanticscholar +1 more source
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]
, 2019 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J. +2 more
core +3 more sources
Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
core +3 more sources
Structural determinants of nuclear export signal orientation in binding to exportin CRM1
eLife, 2015 The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung +3 more
doaj +1 more source