Results 11 to 20 of about 9,261 (202)

Structural Basis of Targeting the Exportin CRM1 in Cancer [PDF]

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Ralf Ficner, Achim Dickmanns, Thomas Monecke   +2 more
exaly   +7 more sources

CRM1 Inhibitors for Antiviral Therapy [PDF]

Frontiers in Microbiology, 2017
Infectious diseases are a major global concern and despite major advancements in medical research, still cause significant morbidity and mortality. Progress in antiviral therapy is particularly hindered by appearance of mutants capable of overcoming the ...
Cynthia Mathew, Reena Ghildyal
doaj   +5 more sources

Small Molecule Inhibitors of CRM1 [PDF]

Frontiers in Pharmacology, 2020
The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal ...
Bibiana I. Ferreira, Bibiana I. Ferreira, Bibiana I. Ferreira, Bastien Cautain, Bastien Cautain, Inês Grenho, Inês Grenho, Inês Grenho, Wolfgang Link   +8 more
doaj   +10 more sources

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein [PDF]

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +4 more sources

CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

Blood, 2011
CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong antitumor properties.
Atsushi Suzuki, Daniel D. VonHoff, Takumi Kawabe, Tadahiko Iwami, Naoya Saito, Yoko Hasegawa, Keiichi Sakakibara, Takuji Sato, Donald W. Kufe, Jonathan M. Friedman   +9 more
core   +4 more sources

Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors

Journal of Medicinal Chemistry, 2023
Cancer cells frequently utilize elevated nuclear export to escape tumor suppression and gain proliferative advantage. Chromosome Region Maintenance 1 (CRM1/XPO1) mediates macromolecule nuclear export and plays an important role in tumorigenesis and ...
Lunan Jian (13201215), Xia Zhang, Robert Zscherp, Robert Zscherp (16851771), Philipp Klahn (1396894), Shiyang Xu, Shiyang Xu (2572336), Xia Zhang (41398), Ulrike Beutling, Ulrike Beutling (518348), Xiaofei Shen (561186), Qingxiang Sun (241307), Xiaofei Shen, Mark Brönstrup, Lunan Jian, Philipp Klahn, Mark Brönstrup (1578493), Qingxiang Sun   +17 more
core   +5 more sources

Structural Determinants and Mechanism of Mammalian CRM1 Allostery [PDF]

Structure, 2013
Proteins carrying nuclear export signals cooperatively assemble with the export factor CRM1 and the effector protein RanGTP. In lower eukaryotes, this cooperativity is coupled to CRM1 conformational changes; however, it is unknown if mammalian CRM1 ...
Grubmüller, H., Grubmüller, Helmut, Voss, B., Haselbach, D., Dölker, Nicole, Zachariae, U., Voß, Béla, Svergun, Dmitri, Monecke, T., Doelker, Nicole, Monecke, Thomas, Kappel, C., Blanchet, Clement E., Zachariae, Ulrich; id_orcid, Zachariae, Ulrich, Ficner, R., Svergun, Dmitri I., Blanchet, C., Doelker, N., Svergun, D., Haselbach, David, BLANCHET, Clement, Stark, H., Stark, Holger, Ficner, Ralf, Kappel, Christian, Dickmanns, Achim, Dickmanns, A.   +27 more
core   +8 more sources

The Nuclear Export Signal of IκBα Drives RelB Oscillations in the Noncanonical NF-κB Pathway. [PDF]

Genes Cells
The IκBα nuclear export signal drives oscillatory dynamics of RelB in the noncanonical NF‐κB pathway. Following LTβR stimulation, p100 processing releases RelB for nuclear import, while IκBα‐mediated CRM1‐dependent nuclear export enables repeated RelB oscillations, regulating NF‐κB target gene expression.
Seki T, Davis S, Miyamoto S, Akiyama T, Nakano H, Inoue JI, Okunishi K.   +6 more
europepmc   +2 more sources

CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm. [PDF]

The Journal of Cell Biology, 1999
Importin β is a major mediator of import into the cell nucleus. Importin β binds cargo molecules either directly or via two types of adapter molecules, importin α, for import of proteins with a classical nuclear localization signal (NLS), or snurportin 1,
Izaurralde, E., Izaurralde, Elisa, Kutay, U., Bischoff, F., F. Ralf Bischoff, Paraskeva, E., Bischoff, F. Ralf, Kutay, Ulrike, Bischoff, F. R., Jochen Huber, Luehrmann, R., Lührmann, Reinhard, Huber, J., Hartmann, E., Reinhard Lührmann, Görlich, D., Paraskeva, Efrosyni, Ulrike Kutay, Dirk Görlich, Elisa Izaurralde, Hartmann, Enno, Görlich, Dirk, Efrosyni Paraskeva, Enno Hartmann, Lührmann, R., Huber, Jochen   +25 more
core   +6 more sources

USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC. [PDF]

Adv Sci (Weinh)
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Bian S, Tong Y, Ni W, Tang Z, Chen W, Ma K, Jiang L, Shao J, He X, Zheng W.   +9 more
europepmc   +2 more sources