Results 11 to 20 of about 7,200 (169)

The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition [PDF]

Molecular Cell
Yifan Cheng, Alan Frankel
exaly   +2 more sources

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma. [PDF]

Chembiochem
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor chromosome region maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Princiotto S, Jiménez L, Domínguez L, Sequeira JGN, Mourato C, Orea-Soufi A, Santos B, Dallavalle S, Machuqueiro M, Ferreira BI, Link W.   +10 more
europepmc   +5 more sources

Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Journal of Biomedical Science, 2022
Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated.
Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin, Chiaho Shih   +5 more
doaj   +1 more source

Viral Subversion of the Chromosome Region Maintenance 1 Export Pathway and Its Consequences for the Cell Host

Viruses, 2023
In eukaryotic cells, the spatial distribution between cytoplasm and nucleus is essential for cell homeostasis. This dynamic distribution is selectively regulated by the nuclear pore complex (NPC), which allows the passive or energy-dependent transport of
Makram Mghezzi-Habellah, Léa Prochasson, Pierre Jalinot, Vincent Mocquet   +3 more
doaj   +1 more source

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae

BMC Molecular and Cell Biology, 2022
Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger   +8 more
doaj   +1 more source

Structural Determinants and Mechanism of Mammalian CRM1 Allostery [PDF]

Structure, 2013
Published by Elsevier Science, London [u.a.]
Dölker, Nicole, BLANCHET, Clement, Voß, Béla, Haselbach, David, Kappel, Christian, Monecke, Thomas, Svergun, Dmitri, Stark, Holger, Ficner, Ralf, Zachariae, Ulrich, Grubmüller, Helmut, Dickmanns, Achim   +11 more
openaire   +6 more sources

A non-canonical mechanism for Crm1-export cargo complex assembly

eLife, 2015
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Ute Fischer, Nico Schäuble, Sabina Schütz, Martin Altvater, Yiming Chang, Marius Boulos Faza, Vikram Govind Panse   +6 more
doaj   +1 more source

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin

Journal of Pharmacological Sciences, 2014
Plumbagin, a naphthoquinone derived from the medicinal plant Plumbago zeylanica, has been shown to exert anti-cancer and anti-proliferative activities in vitro as well as in animal tumor models.
Xuejiao Liu, Mingshan Niu, Xiaoyu Xu, Wei Cai, Lingyu Zeng, Xiuping Zhou, Rutong Yu, Kailin Xu   +7 more
doaj   +1 more source

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros   +6 more
doaj   +1 more source