Results 11 to 20 of about 18,104 (240)
Structural Basis of Targeting the Exportin CRM1 in Cancer [PDF]
Cells, 2015 Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Ralf Ficner
exaly +6 more sources
Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]
Journal of VirologyThogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson +6 more
doaj +2 more sources
Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos [PDF]
BiomoleculesCRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have pinpointed several key residues (A541, F572, K568, S1055, and Q742) that modulate CRM1 export ...
Miren Josu Omaetxebarria +5 more
doaj +2 more sources
eLife, 2019 We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust activation of Hox genes (Oka et al., 2016).
Masahiro Oka +9 more
doaj +2 more sources
Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase [PDF]
Nature CommunicationsThe human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.
Vladimir Baytshtok +2 more
doaj +2 more sources
The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport [PDF]
Journal of Cell Science, 2017 Transport of large cargo through the cytoplasm requires motor proteins and polarized filaments. Viruses that replicate in the nucleus of post-mitotic cells use microtubules and the dynein/dynactin motor to traffic to the nuclear membrane, and deliver ...
Wang, I-Hsuan +4 more
core +5 more sources
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
doaj +2 more sources
A non-canonical mechanism for Crm1-export cargo complex assembly
eLife, 2015 The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Ute Fischer +6 more
doaj +4 more sources
PLoS ONE, 2020 The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear ...
Catherine P Lavau +7 more
doaj +2 more sources
The past, present, and future of CRM1/XPO1 inhibitors.
Stem Cell Investigation, 2019 Therapies targeted at inhibiting nucleo-cytoplasmic transport have found broad applications in the field of oncology. Chromosome region maintenance 1 (CRM1), better known as exportin 1 (XPO1), is the protein transporter responsible for the nucleo ...
A. Wang, Hongtao Liu
semanticscholar +3 more sources