Results 31 to 40 of about 73,362 (284)
Identification of Nuclear Export Signals in Antizyme-1 [PDF]
Journal of Biological Chemistry, 2003 Antizyme-1 (AZ1) is a protein that negatively regulates polyamine synthesis by inhibiting the key synthetic enzyme ornithine decarboxylase and targeting it for degradation by the 26 S proteasome. Recent work shows that antizyme protein translocates to the nucleus during mouse development (Gritli-Linde, A., Nilssom, J., Bohlooly, Y.
Noriyuki, Murai +2 more
openaire +2 more sources
Nuclear Import and Export Signals in Control of Nrf2 [PDF]
Journal of Biological Chemistry, 2005 Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes. In this study, we have identified nuclear import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is regulated by antioxidants.
Abhinav K, Jain +2 more
openaire +3 more sources
Cell Reports, 2013 Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A ...
José Manuel Mingot +4 more
doaj +1 more source
Arabidopsis NMD3 is required for nuclear export of 60S ribosomal subunits and affects secondary cell wall thickening. [PDF]
PLoS ONE, 2012 NMD3 is required for nuclear export of the 60S ribosomal subunit in yeast and vertebrate cells, but no corresponding function of NMD3 has been reported in plants.
Mei-Qin Chen +12 more
doaj +1 more source
FEBS Open Bio, 2014 The influenza virus replicates in the host cell nucleus, and the progeny viral ribonucleoprotein complex (vRNP) is exported to the cytoplasm prior to maturation.
Ken Watanabe +5 more
doaj +1 more source
Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Nature Communications, 2021 Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal ...
Annika Meiners +14 more
doaj +1 more source
Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine‐rich nuclear export signals in Arabidopsis thaliana [PDF]
The Plant Journal, 1999 SummaryTransport across the nuclear envelope is mediated by transport receptors from the Importin β family. We identified Exportin 1 from Arabidopsis (AtXPO1/AtCRM1) as the nuclear export receptor for proteins carrying leucine‐rich nuclear export signals (NESs). AtXPO1 shares 42–50% identity with its functional homologues from humans and yeasts.
Haasen, D. +3 more
openaire +4 more sources
PLoS ONE, 2011 Background9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES),
Kulbhushan Sharma +9 more
doaj +1 more source
A nuclear role for the DEAD-box protein Dbp5 in tRNA export
eLife, 2019 Dbp5 is an essential DEAD-box protein that mediates nuclear mRNP export. Dbp5 also shuttles between nuclear and cytoplasmic compartments with reported roles in transcription, ribosomal subunit export, and translation; however, the mechanism(s) by which ...
Azra Lari +7 more
doaj +1 more source
PLoS ONE, 2015 The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha +3 more
doaj +1 more source