The signal sequence coding region promotes nuclear export of mRNA. [PDF]
PLoS Biology, 2007 In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping.
Alexander F Palazzo +5 more
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A Supraphysiological Nuclear Export Signal Is Required for Parvovirus Nuclear Export [PDF]
Molecular Biology of the Cell, 2008 CRM1 exports proteins that carry a short leucine-rich peptide signal, the nuclear export signal (NES), from the nucleus. Regular NESs must have low affinity for CRM1 to function optimally. We previously generated artificial NESs with higher affinities for CRM1, termed supraphysiological NESs.
Engelsma, Dieuwke +5 more
openaire +5 more sources
A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway [PDF]
Cell, 1995 Pre-mRNAs are associated with hnRNPs, and these proteins play important roles in the biogenesis of mRNAs. The hnRNP A1 is one of the most abundant hnRNPs, and although localized primarily in the nucleoplasm, shuttles continuously between the nucleus and the cytoplasm.
Matthew Michael, W. +2 more
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals [PDF]
Cell, 1997 CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin that is shown to bind to CRM1 protein, specifically inhibits the nuclear export
Fornerod, Maarten +3 more
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mTOR-dependent phosphorylation controls TFEB nuclear export [PDF]
Nature Communications, 2018 On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates ...
Gennaro Napolitano +9 more
doaj +4 more sources
CRM1/Ran-Mediated Nuclear Export of p27Kip1Involves a Nuclear Export Signal and Links p27 Export and Proteolysis [PDF]
Molecular Biology of the Cell, 2003 We show that p27 localization is cell cycle regulated and we suggest that active CRM1/RanGTP-mediated nuclear export of p27 may be linked to cytoplasmic p27 proteolysis in early G1. p27 is nuclear in G0 and early G1 and appears transiently in the cytoplasm at the G1/S transition. Association of p27 with the exportin CRM1 was minimal in G0 and increased
Connor, M. +8 more
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Virology, 2006 Morbilliviruses, which belong to the Mononegavirales, replicate its RNA genome in the cytoplasm of the host cell. However, they also form characteristic intranuclear inclusion bodies, consisting of nucleoprotein (N), in infected cells. To analyze the mechanisms of nucleocytoplasmic transport of N protein, we characterized the nuclear localization (NLS)
Chieko Kai +2 more
exaly +3 more sources
Nuclear enlargement induced by overexpression of nuclear export signal is associated with abnormal nuclear division in Schizosaccharomyces pombe [PDF]
Biology OpenTakahiro Fujimoto +4 more
doaj +2 more sources
MOS11: a new component in the mRNA export pathway. [PDF]
PLoS Genetics, 2010 Nucleocytoplasmic trafficking is emerging as an important aspect of plant immunity. The three related pathways affecting plant immunity include Nuclear Localization Signal (NLS)-mediated nuclear protein import, Nuclear Export Signal (NES)-dependent ...
Hugo Germain +12 more
doaj +1 more source
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Nature Communications, 2023 Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side of the NPC ...
Prasanna Bhat +18 more
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