CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals [PDF]
Cell, 1997 CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin that is shown to bind to CRM1 protein, specifically inhibits the nuclear export
Fornerod, Maarten +3 more
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Cell, 1995 Pre-mRNAs are associated with hnRNPs, and these proteins play important roles in the biogenesis of mRNAs. The hnRNP A1 is one of the most abundant hnRNPs, and although localized primarily in the nucleoplasm, shuttles continuously between the nucleus and the cytoplasm.
Matthew Michael, W. +2 more
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Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein [PDF]
Virology Journal, 2017 Background Borna disease virus (BoDV), which has a negative-sense, single-stranded RNA genome, causes persistent infection in the cell nucleus. The nuclear export signal (NES) of the viral nucleoprotein (N) consisting of leucine at positions 128 and 131 ...
Mako Yanai +3 more
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mTOR-dependent phosphorylation controls TFEB nuclear export
Nature Communications, 2018 On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates ...
Gennaro Napolitano +9 more
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Characterisation of the tilapia lake virus proteome and identification of an 11th protein, S9-F3 [PDF]
npj VirusesTilapia Lake Virus (TiLV) is an emerging RNA virus threatening global tilapia aquaculture. While proteins encoded by segments 1–3 (polymerase) and 4 (nucleoprotein) are characterised, the functions of polypeptides from the remaining segments remain ...
Nunticha Pankaew +7 more
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Nuclear enlargement induced by overexpression of nuclear export signal is associated with abnormal nuclear division in Schizosaccharomyces pombe [PDF]
Biology OpenTakahiro Fujimoto +4 more
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MOS11: a new component in the mRNA export pathway. [PDF]
PLoS Genetics, 2010 Nucleocytoplasmic trafficking is emerging as an important aspect of plant immunity. The three related pathways affecting plant immunity include Nuclear Localization Signal (NLS)-mediated nuclear protein import, Nuclear Export Signal (NES)-dependent ...
Hugo Germain +12 more
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Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Nature Communications, 2023 Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side of the NPC ...
Prasanna Bhat +18 more
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FAK nuclear export signal sequences [PDF]
FEBS Letters, 2008 Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only ...
Ossovskaya, Valeria +4 more
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A Supraphysiological Nuclear Export Signal Is Required for Parvovirus Nuclear Export [PDF]
Molecular Biology of the Cell, 2008 CRM1 exports proteins that carry a short leucine-rich peptide signal, the nuclear export signal (NES), from the nucleus. Regular NESs must have low affinity for CRM1 to function optimally. We previously generated artificial NESs with higher affinities for CRM1, termed supraphysiological NESs.
Engelsma, Dieuwke +5 more
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