Results 51 to 60 of about 177,922 (281)

NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles. [PDF]

PLoS Computational Biology, 2014
The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by ...
Shunichi Kosugi, Hiroshi Yanagawa, Ryohei Terauchi, Satoshi Tabata   +3 more
doaj   +1 more source

CRM1/Ran-Mediated Nuclear Export of p27^Kip1Involves a Nuclear Export Signal and Links p27 Export and Proteolysis [PDF]

Molecular Biology of the Cell, 2003
We show that p27 localization is cell cycle regulated and we suggest that active CRM1/RanGTP-mediated nuclear export of p27 may be linked to cytoplasmic p27 proteolysis in early G1. p27 is nuclear in G0 and early G1 and appears transiently in the cytoplasm at the G1/S transition. Association of p27 with the exportin CRM1 was minimal in G0 and increased
Connor, M., Kotchetkov, R., Cariou, S., Resch, A., Lupetti, R., Beniston, R., Melchior, F., Hengst, L., Slingerland, J.   +8 more
openaire   +3 more sources

A non-canonical mechanism for Crm1-export cargo complex assembly

eLife, 2015
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Ute Fischer, Nico Schäuble, Sabina Schütz, Martin Altvater, Yiming Chang, Marius Boulos Faza, Vikram Govind Panse   +6 more
doaj   +1 more source

Evidence for anthropogenic ¹⁴C-enrichment in estuarine waters adjacent to the North Sea [PDF]

, 2006
[1] The isotopic composition (d13C and D14C) of high molecular weight dissolved organic carbon (HMW DOC) was studied in the Tyne and Tweed estuaries, NE England.
Ahad, J.M.E., Bryant, C., Ganeshram, R.S., Gulliver, P., Spencer, R.G.M., Uher, G.   +5 more
core   +1 more source

Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates [PDF]

Proceedings of the National Academy of Sciences, 1997
Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here
A E, Pasquinelli, M A, Powers, E, Lund, D, Forbes, J E, Dahlberg   +4 more
openaire   +2 more sources

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Scientific Reports, 2018
ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol.
Emile S. Pinarbasi, Tolga Cağatay, Ho Yee Joyce Fung, Ying C. Li, Yuh Min Chook, Philip J. Thomas   +5 more
doaj   +1 more source

Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus

Viruses, 2014
The nucleolus is a dynamic subnuclear structure, which is crucial to the normal operation of the eukaryotic cell. The porcine epidemic diarrhea virus (PEDV), coronavirus nucleocapsid (N) protein, plays important roles in the process of virus replication ...
Da Shi, Maojie Lv, Jianfei Chen, Hongyan Shi, Sha Zhang, Xin Zhang, Li Feng   +6 more
doaj   +1 more source

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

A Nuclear Export Signal Prevents Saccharomyces cerevisiae Hsp70 Ssb1p from Stimulating Nuclear Localization Signal-directed Nuclear Transport [PDF]

Journal of Biological Chemistry, 1999
Hsp70 has been implicated in nuclear localization signal (NLS)-directed nuclear transport. Saccharomyces cerevisiae contains distinct SSA and SSB gene families of cytosolic Hsp70s. The nucleocytoplasmic localization of Ssa1p and Ssb1p was investigated using green fluorescent protein (GFP) fusions.
N, Shulga, P, James, E A, Craig, D S, Goldfarb   +3 more
openaire   +2 more sources

Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [PDF]

, 2018
Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways.
Balda, María S., García Miranda, Pablo, Ilundáin Larrañeta, María Anunciación Ana, Matter, Karl, Peral Rubio, María José, Vázquez Carretero, María Dolores   +5 more
core   +1 more source