Results 51 to 60 of about 3,507,867 (287)

tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes [PDF]

, 2006
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Zaitseva Lyubov, Fassati Ariberto, Myers Richard, Myers, R, Lyubov Zaitseva, Ariberto Fassati, Fassati, A, Richard Myers, Zaitseva, L   +8 more
core   +1 more source

Model system to study classical nuclear export signals [PDF]

AAPS PharmSci, 2002
Signal-mediated protein transport through the nuclear pore complex is of considerable interest in the field of molecular pharmaceutics. Nuclear localization signals can be used to target genes/antisense delivery systems to the nucleus. Studying nuclear export is useful in enhancing the expression and the efficiency of action of these therapeutic agents.
Charu, Kanwal, Henan, Li, Carol S, Lim
openaire   +2 more sources

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1 [PDF]

, 2015
Controlled transport of macromolecules between the cytoplasm and nucleus is essential for homeostatic regulation of cellular functions. For instance, gene expression entails coordinated nuclear import of transcriptional regulators to activate ...
Vartiainen, Maria K., Treisman, Richard, Kyheröinen, Salla, Rajakylä, Eeva Kaisa, Huet, Guillaume, Viita, Tiina   +5 more
core   +1 more source

Data for: Nuclear localization signal regulates Porcine Circovirus type 2 Capsid protein nuclear export through phosphorylation

, 2018
Data for: Nuclear localization signal regulates Porcine Circovirus type 2 Capsid protein nuclear export through ...
Xiaoyu Guo (280620), Yitong Jiang (7003859), Hongfei Zhu (1622464), Hong Jia (741273), Shaohua Hou (4914478), Ting Xin (4914469), Qiang Hou (495704), Qing Chen (131379)   +7 more
core   +2 more sources

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Scientific Reports, 2018
ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol.
Emile S. Pinarbasi, Tolga Cağatay, Ho Yee Joyce Fung, Ying C. Li, Yuh Min Chook, Philip J. Thomas   +5 more
doaj   +1 more source

Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus

Viruses, 2014
The nucleolus is a dynamic subnuclear structure, which is crucial to the normal operation of the eukaryotic cell. The porcine epidemic diarrhea virus (PEDV), coronavirus nucleocapsid (N) protein, plays important roles in the process of virus replication ...
Da Shi, Maojie Lv, Jianfei Chen, Hongyan Shi, Sha Zhang, Xin Zhang, Li Feng   +6 more
doaj   +1 more source

Huntingtin contains a highly conserved nuclear export signal [PDF]

Human Molecular Genetics, 2003
Huntington's disease (HD), is a genetic neurodegenerative disease characterized by a DNA CAG triplet repeat expansion in the first exon of the disease gene, HD. CAG DNA expansion results in a polyglutamine tract expansion in mutant huntingtin protein. Wild-type and mutant full-length huntingtin have been detected in the nucleus, but elevated levels of ...
Jianrun, Xia, Denise H, Lee, Jillian, Taylor, Mark, Vandelft, Ray, Truant   +4 more
openaire   +2 more sources

Nuclear phosphoinositide signaling regulates messenger RNA export [PDF]

RNA Biology, 2009
Messenger RNA export from the nucleus to the cytoplasm plays an essential role in linking transcription to translation and consequently regulation of protein expression. mRNA export requires a series of events: pre-mRNA processing, ribonucleoprotein targeting to the NPC (nuclear pore complexes), and translocation through nuclear pores to the cytoplasm.
Masashi, Okada, Keqiang, Ye
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The plasmodium export element revisited [PDF]

, 2008
We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking ...
Florian Schwarte, Schwarte Florian, Przyborski, Jude Marek, Lingelbach Klaus, Przyborski Jude Marek, Gisbert Schneider, Hiß, Jan Alexander, Lingelbach, Klaus, Jude Marek Przyborski, Klaus Lingelbach, Schwarte, Florian, Hiss Jan Alexander, Schneider, Gisbert (Prof. Dr.), Jan Alexander Hiss, Schneider Gisbert   +14 more
core   +1 more source