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RNA Biology, 2022 The nuclear pore complex (NPC) facilitates the trafficking of proteins and RNA between the nucleus and cytoplasm. The role of nucleoporins (Nups) in transport in the context of the NPC is well established, yet their function in tRNA export has not been ...
Sneha S Kulkarni +2 more
exaly +3 more sources
The nuclear pore complex as a spatial organizing hub for high-risk DNA lesions [PDF]
NucleusThe nuclear pore complex (NPC) is best known for nucleocytoplasmic transport, but growing evidence implicates nucleoporins and NPC-associated environments in genome maintenance.
Dante DeAscanis +3 more
doaj +2 more sources
NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.
PLoS ONE, 2019 Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius +2 more
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Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski +3 more
doaj +3 more sources
Pathologies at the gateway: exploring the link between nucleoporins and inherited diseases [PDF]
Cellular and Molecular Life SciencesNuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus and cytoplasm. While they are fundamental to
Daniela A. Braun +3 more
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Nature Communications, 2020 Characterizing the assembly of the nuclear pore complex (NPC) remains challenging. Here, the authors develop a set of nanobodies that recognize seven constituent nucleoporins, study their binding characteristics, and apply them to probe accessible and ...
Sarah A. Nordeen +5 more
doaj +2 more sources
Regulation of nucleoporins in mitosis
, 2007 Nucleoporins mediate nucleocytoplasmic trafficking in interphase. In mitosis, upon nuclear envelope breakdown, the role and regulation of Nups remain to be elucidated.
Chakraborty, Papia
core +7 more sources
Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors [PDF]
eLife, 2013 Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are
Kasper R Andersen +8 more
doaj +2 more sources
Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention. [PDF]
Adv MaterCancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Stefanello ST +5 more
europepmc +2 more sources
Cells, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
doaj +1 more source