Results 1 to 10 of about 5,346 (178)

In Pursuit of Distinctiveness: Transmembrane Nucleoporins and Their Disease Associations

Frontiers in Oncology, 2021
The bi-directional nucleocytoplasmic shuttling of macromolecules like molecular signals, transcription factors, regulatory proteins, and RNAs occurs exclusively through Nuclear Pore Complex (NPC) residing in the nuclear membrane. This magnanimous complex
Ram Mishra
exaly   +3 more sources

Trafficking and/or division: Distinct roles of nucleoporins based on their location within the nuclear pore complex

RNA Biology, 2022
The nuclear pore complex (NPC) facilitates the trafficking of proteins and RNA between the nucleus and cytoplasm. The role of nucleoporins (Nups) in transport in the context of the NPC is well established, yet their function in tRNA export has not been ...
Sneha Kulkarni, Eva Hegedüsová, Zdenek Paris   +2 more
exaly   +2 more sources

Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint

Cells, 2015
The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Birthe Fahrenkrog, Fahrenkrog Birthe
exaly   +3 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +2 more sources

Pathologies at the gateway: exploring the link between nucleoporins and inherited diseases [PDF]

Cellular and Molecular Life Sciences
Nuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus and cytoplasm. While they are fundamental to
Daniela A. Braun, Ramona Jühlen, Vanessa Krausel, Wolfram Antonin   +3 more
doaj   +2 more sources

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways [PDF]

Viruses
Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Richard W. Wong   +4 more
doaj   +2 more sources

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease [PDF]

Nucleus
The vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli ...
Tung D. Nguyen, Michael A. Winek, Mihir K. Rao, Shaiva P. Dhyani, Monica Y. Lee   +4 more
doaj   +2 more sources

Nucleoporins cooperate with Polycomb silencers to promote transcriptional repression and repair at DNA double-strand breaks [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Kyungjae Myung, Younghoon Kee, Michele Pagano   +2 more
exaly   +2 more sources

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

Cells, 2021
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah, Keesiang Lim, Richard W. Wong   +2 more
doaj   +1 more source

Role of Nucleoporins and Transport Receptors in Cell Differentiation

Frontiers in Physiology, 2020
Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan, Rongmei Qu, Jun Ouyang, Jingxing Dai   +3 more
doaj   +1 more source