Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex [PDF]
eLife, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk +7 more
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The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]
Frontiers in Cell and Developmental BiologyThe nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu +10 more
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Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors [PDF]
eLife, 2013 Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are
Kasper R Andersen +8 more
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Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways [PDF]
VirusesViruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang +4 more
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Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease [PDF]
NucleusThe vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli ...
Tung D. Nguyen +4 more
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Cells, 2021 The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah +2 more
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In Pursuit of Distinctiveness: Transmembrane Nucleoporins and Their Disease Associations
Frontiers in Oncology, 2021 The bi-directional nucleocytoplasmic shuttling of macromolecules like molecular signals, transcription factors, regulatory proteins, and RNAs occurs exclusively through Nuclear Pore Complex (NPC) residing in the nuclear membrane. This magnanimous complex
Divya Bindra, Ram Kumar Mishra
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RNA Biology, 2022 The nuclear pore complex (NPC) facilitates the trafficking of proteins and RNA between the nucleus and cytoplasm. The role of nucleoporins (Nups) in transport in the context of the NPC is well established, yet their function in tRNA export has not been ...
Eva Hegedűsová +3 more
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Role of Nucleoporins and Transport Receptors in Cell Differentiation
Frontiers in Physiology, 2020 Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan +3 more
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Channel nuclear pore complex subunits are required for transposon silencing in Drosophila
eLife, 2021 The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting with ...
Marzia Munafò +8 more
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