Results 31 to 40 of about 6,360 (219)
Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
Nature Communications, 2020 mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-
Vasilisa Aksenova +12 more
doaj +1 more source
Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot
Frontiers in Cardiovascular Medicine, 2020 Functional variants in nuclear envelope genes are implicated as underlying causes of cardiopathology. To examine the potential association of single nucleotide variants of nucleoporin genes with cardiac disease, we employed a prognostic scoring approach ...
Riley J. Leonard +8 more
doaj +1 more source
Nucleoporins in cardiovascular disease
Journal of Molecular and Cellular Cardiology, 2020 Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment.
Ryan D, Burdine +4 more
openaire +3 more sources
A-type lamins involvement in transport and implications in cancer?
Nucleus, 2022 Nuclear lamins and transport are intrinsically linked, but their relationship is yet to be fully unraveled. A multitude of complex, coupled interactions between lamins and nucleoporins (Nups), which mediate active transport into and out of the nucleus ...
Nicholas R. Scott, Sapun H. Parekh
doaj +1 more source
A mosaic of old and young nucleoporins [PDF]
Journal of Cell Biology, 2019 Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in ...
Takeshi Shimi, Hiroshi Kimura
openaire +2 more sources
Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
Viruses, 2021 Picornaviruses are positive-stranded RNA viruses. Even though replication and translation of their genome take place in the cytoplasm, these viruses evolved different strategies to disturb nucleocytoplasmic trafficking of host proteins and RNA. The major
Belén Lizcano-Perret, Thomas Michiels
doaj +1 more source
Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]
, 2008 Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike +2 more
core +1 more source
Cells, 2022 Dictyostelium cells undergo a semi-closed mitosis, during which the nuclear envelope (NE) persists; however, free diffusion between the cytoplasm and the nucleus takes place.
Kristina Mitic +3 more
doaj +1 more source
Regulation of autophagy by nucleoporin Tpr [PDF]
Scientific Reports, 2012 The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Funasaka, Tatsuyoshi +2 more
openaire +2 more sources
Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]
, 2014 Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core +1 more source