Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.
PLoS ONE, 2019 Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius +2 more
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Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner
Frontiers in Cell and Developmental Biology, 2021 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán +11 more
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Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]
, 2015 The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL +3 more
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Functional interactions between nucleoporins and chromatin [PDF]
Current Opinion in Cell Biology, 2011 As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
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Nucleoporins facilitate ORC loading onto chromatin
Cell Reports, 2022 SUMMARYThe origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed immunoprecipitations coupled with mass spectrometry for ORC2 in Drosophila embryos.
Logan Richards +4 more
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Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]
, 2018 Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana +6 more
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Structure-function mapping of a heptameric module in the nuclear pore complex. [PDF]
, 2012 The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative approach to determine the structure of an essential component of the yeast ...
Chait, Brian T +10 more
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A Nucleoporin at the Meiotic Kinetochore [PDF]
Developmental Cell, 2016 In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
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Host-HIV-1 Interactome: A Quest for Novel Therapeutic Intervention
Cells, 2019 The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily ...
Ekta Shukla, Radha Chauhan
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