Results 51 to 60 of about 10,026 (221)
A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
core +2 more sources
Linking Nucleoporins, Mitosis, and Colon Cancer [PDF]
Cell Chemical Biology, 2016 Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival.
Richard W, Wong, Maximiliano, D'Angelo
openaire +2 more sources
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up [PDF]
, 2016 Elucidating the structure of the nuclear pore complex (NPC) is a prerequisite for understanding the molecular mechanism of nucleocytoplasmic transport.
Beck, Martina +2 more
core +1 more source
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity
Life Science Alliance, 2022 This study describes the the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function. Nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, are built by multiple copies of ∼30 ...
Stephen Sakuma +5 more
doaj +1 more source
NUP214 (nucleoporin 214kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NUP214 (nucleoporin 214kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +1 more source
Shaping the p53 Response with Nucleoporins [PDF]
Molecular Cell, 2012 In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L. +2 more
openaire +2 more sources
NUP98 (nucleoporin 98 kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +3 more sources
Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. [PDF]
, 2014 Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells.
Banerjee, Utpal +3 more
core +1 more source
Investigation of tracer diffusion in crowded cylindrical channel
, 2012 Based on a coarse-grained model, we carry out molecular dynamics simulations to analyze the diffusion of a small tracer particle inside a cylindrical channel whose inner wall is covered with randomly grafted short polymeric chains.
Chakrabarti, Rajarshi +3 more
core +2 more sources
The Nuclear Pore Complex as a Flexible and Dynamic Gate [PDF]
, 2018 Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm.
Knockenhauer, Kevin Edward +1 more
core +1 more source