Results 51 to 60 of about 6,849 (214)

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

eLife, 2015
Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules.
Loren E Hough, Kaushik Dutta, Samuel Sparks, Deniz B Temel, Alia Kamal, Jaclyn Tetenbaum-Novatt, Michael P Rout, David Cowburn   +7 more
doaj   +1 more source

Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity

Life Science Alliance, 2022
This study describes the  the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function. Nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, are built by multiple copies of ∼30 ...
Stephen Sakuma, Ethan YS Zhu, Marcela Raices, Pan Zhang, Rabi Murad, Maximiliano A D’Angelo   +5 more
doaj   +1 more source

Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms [PDF]

Genes to Cells, 2010
The nucleoporin Nup98 is an essential component of the nuclear pore complex. This peripheral nucleoporin with its Gly‐Leu‐Phe‐Gly (GLFG) repeat domain contributes to nuclear‐cytoplasmic trafficking, including mRNA export. In addition, accumulating studies indicate that Nup98 plays roles in several important biological events such as gene expression ...
Masaaki, Iwamoto, Haruhiko, Asakawa, Yasushi, Hiraoka, Tokuko, Haraguchi   +3 more
openaire   +2 more sources

Nuclear entry of DNA viruses

Frontiers in Microbiology, 2015
DNA viruses undertake their replication within the cell nucleus, and therefore they must first deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear envelope is at the basis of DNA virus infections.
Nikta eFay, Nelly ePante
doaj   +1 more source

Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer

Epigenomes, 2018
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston, Randolph S. Faustino   +1 more
doaj   +1 more source

Rae1: A new clue for nucleoporin leukemias [PDF]

Cell Cycle, 2011
N ...
Stuwe, Tobias, Hoelz, André
openaire   +3 more sources

Systems genomics of nucleoporins provides prognostic insights into breast cancer [PDF]

, 2022
Background: Nucleoporins (Nups) constitute a large group of proteins that are structurally arranged at the nuclear envelope and facilitate the bidirectional movement of molecules across the nuclear membrane.
Jibiki, Kazuya, Alsafwani, Zakeya J., Naseem, Muhammad, Mehmood, Rashid, Yasuhara, Noriko   +4 more
core  

Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster

eLife
Nuclear pore complexes (NPCs), composed of nucleoporins (Nups), affect nucleocytoplasmic transport, thus influencing cell division and gene regulation.
Jyotsna Kawadkar, Pradyumna Ajit Joshi, Ram Kumar Mishra   +2 more
doaj   +1 more source

HIV Nuclear Entry: Clearing the Fog

Viruses, 2010
HIV-1 and other lentiviruses have the unusual capability of infecting nondividing cells, but the mechanism by which they cross an intact nuclear membrane is mysterious.
Vaibhav B. Shah, Christopher Aiken
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source