Results 41 to 50 of about 6,360 (219)
Viruses, 2022 Human immunodeficiency virus-1 (HIV-1) is a retrovirus that integrates its reverse-transcribed genome as proviral DNA into the host genome to establish a successful infection.
Satarupa Sarkar +7 more
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Non-classical functions of nuclear pore proteins in ciliopathy
Frontiers in Molecular Biosciences, 2023 Nucleoporins (NUPs) constitute integral nuclear pore protein (NPC) elements. Although traditional NUP functions have been extensively researched, evidence of additional vital non-NPC roles, referred to herein as non-classical NUP functions, is also ...
Yan Chen, Yuan Zhang, Xiangyu Zhou
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
Valeria, Nofrini +2 more
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Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner
Frontiers in Cell and Developmental Biology, 2021 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán +11 more
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Shaping the p53 Response with Nucleoporins [PDF]
Molecular Cell, 2012 In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L. +2 more
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, 2023 Nuclear Pore Complexes (NPCs) are embedded in the nuclear envelope (NE), regulating macromolecule transport and physically interacting with chromatin. The NE undergoes dramatic breakdown and reformation during plant cell division.
Martinez-Garcia, Marina +5 more
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Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
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Frontiers in Plant Science, 2014 Mutations in the Lotus japonicus nucleoporin genes, NUP85, NUP133 and NENA (SEH1), lead to defects in plant-microbe symbiotic signaling. The homologous proteins in yeast and vertebrates are part of the conserved NUP84/NUP107-160 sub-complex, which is an ...
Andreas eBinder, Martin eParniske
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The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo
Biomedicines, 2021 Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment.
Lavrentii G. Danilov +6 more
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