Results 21 to 30 of about 5,346 (178)
A mosaic of old and young nucleoporins [PDF]
Journal of Cell Biology, 2019 Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in ...
Takeshi Shimi, Hiroshi Kimura
openaire +2 more sources
The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo
Biomedicines, 2021 Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment.
Lavrentii G. Danilov +6 more
doaj +1 more source
Regulation of autophagy by nucleoporin Tpr [PDF]
Scientific Reports, 2012 The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Funasaka, Tatsuyoshi +2 more
openaire +2 more sources
Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
NOFRINI, VALERIA +2 more
openaire +2 more sources
Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons
Life, 2023 Nucleoporins (NUPs) are proteins that comprise the nuclear pore complexes (NPCs). The NPC spans the nuclear envelope of a cell and provides a channel through which RNA and proteins move between the nucleus and the cytoplasm and vice versa.
Vladimir A. Martínez-Rojas +6 more
doaj +1 more source
NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.
PLoS ONE, 2019 Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius +2 more
doaj +1 more source
Shaping the p53 Response with Nucleoporins [PDF]
Molecular Cell, 2012 In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L. +2 more
openaire +2 more sources
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also ...
Sarma, Nayan J, Willis, Kristine
openaire +3 more sources
A-type lamins involvement in transport and implications in cancer?
Nucleus, 2022 Nuclear lamins and transport are intrinsically linked, but their relationship is yet to be fully unraveled. A multitude of complex, coupled interactions between lamins and nucleoporins (Nups), which mediate active transport into and out of the nucleus ...
Nicholas R. Scott, Sapun H. Parekh
doaj +1 more source
Host-HIV-1 Interactome: A Quest for Novel Therapeutic Intervention
Cells, 2019 The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily ...
Ekta Shukla, Radha Chauhan
doaj +1 more source