Results 11 to 20 of about 5,346 (178)
Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski +3 more
doaj +3 more sources
Channel nuclear pore complex subunits are required for transposon silencing in Drosophila
eLife, 2021 The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting with ...
Marzia Munafò +8 more
doaj +1 more source
A Nucleoporin at the Meiotic Kinetochore [PDF]
Developmental Cell, 2016 In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
openaire +2 more sources
Multifunctionality of F-rich nucleoporins [PDF]
Biochemical Society Transactions, 2020 Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way ...
Nike Heinß +3 more
openaire +2 more sources
The Nuclear Life of Nucleoporins [PDF]
Developmental Cell, 2007 Nucleoporins are the constituents of the nuclear pore complex, but they are also known to shuttle to the nuclear interior, the function of which is unclear. In a recent issue of Nature Cell Biology, Wang et al.'s mechanistic studies of leukemogenic fusion proteins that contain nucleoporins suggest that they have a direct role in transcription.
Kalverda, Bernike, Fornerod, Maarten
openaire +2 more sources
Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner
Frontiers in Cell and Developmental Biology, 2021 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán +11 more
doaj +1 more source
Autoproteolysis in nucleoporin biogenesis [PDF]
Proceedings of the National Academy of Sciences, 1999 We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly ...
J S, Rosenblum, G, Blobel
openaire +2 more sources
Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
Nature Communications, 2020 mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-
Vasilisa Aksenova +12 more
doaj +1 more source
Nucleoporins in cardiovascular disease
Journal of Molecular and Cellular Cardiology, 2020 Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment.
Ryan D, Burdine +4 more
openaire +3 more sources
Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot
Frontiers in Cardiovascular Medicine, 2020 Functional variants in nuclear envelope genes are implicated as underlying causes of cardiopathology. To examine the potential association of single nucleotide variants of nucleoporin genes with cardiac disease, we employed a prognostic scoring approach ...
Riley J. Leonard +8 more
doaj +1 more source