Results 11 to 20 of about 6,360 (219)
RNA Biology, 2022 The nuclear pore complex (NPC) facilitates the trafficking of proteins and RNA between the nucleus and cytoplasm. The role of nucleoporins (Nups) in transport in the context of the NPC is well established, yet their function in tRNA export has not been ...
Eva Hegedüsová +2 more
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NPHP proteins are binding partners of nucleoporins at the base of the primary cilium.
PLoS ONE, 2019 Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues.
T Lynne Blasius +2 more
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Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]
Cells, 2021 Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski +3 more
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The nuclear envelope and nuclear pore complexes in neurodegenerative diseases [PDF]
Frontiers in Cell and Developmental BiologyThe nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu +10 more
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Pathologies at the gateway: exploring the link between nucleoporins and inherited diseases [PDF]
Cellular and Molecular Life SciencesNuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus and cytoplasm. While they are fundamental to
Daniela A. Braun +3 more
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The Multiple Faces of Disordered Nucleoporins
Journal of Molecular Biology, 2016 An evolutionary advantage of intrinsically disordered proteins (IDPs) is their ability to bind a variety of folded proteins-a paradigm that is central to the nucleocytoplasmic transport mechanism, in which nuclear transport receptors mediate the translocation of various cargo through the nuclear pore complex by binding disordered phenylalanine-glycine ...
Lemke, Edward A.
openaire +3 more sources
Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways [PDF]
VirusesViruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang +4 more
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Nature Communications, 2020 Characterizing the assembly of the nuclear pore complex (NPC) remains challenging. Here, the authors develop a set of nanobodies that recognize seven constituent nucleoporins, study their binding characteristics, and apply them to probe accessible and ...
Sarah A. Nordeen +5 more
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Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease [PDF]
NucleusThe vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli ...
Tung D. Nguyen +4 more
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Dynein Light Chain 1 (DYNLT1) Interacts with Normal and Oncogenic Nucleoporins. [PDF]
PLoS ONE, 2013 The chimeric oncoprotein NUP98-HOXA9 results from the t(7;11)(p15;p15) chromosomal translocation and is associated with acute myeloid leukemia. It causes aberrant gene regulation and leukemic transformation through mechanisms that are not fully ...
Nayan J Sarma, Nabeel R Yaseen
doaj +3 more sources