Results 61 to 70 of about 6,360 (219)
Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms [PDF]
Genes to Cells, 2010 The nucleoporin Nup98 is an essential component of the nuclear pore complex. This peripheral nucleoporin with its Gly‐Leu‐Phe‐Gly (GLFG) repeat domain contributes to nuclear‐cytoplasmic trafficking, including mRNA export. In addition, accumulating studies indicate that Nup98 plays roles in several important biological events such as gene expression ...
Masaaki, Iwamoto +3 more
openaire +2 more sources
Emerging roles for nucleoporins in reproductive cellular physiology
, 2018 Nucleoporins are a specialized subset of nuclear proteins that comprise the nuclear pore complex and regulate nucleocytoplasmic transport. Recent demonstrations of roles for individual nucleoporins in multiple paradigms of differentiation via mechanisms ...
Storm, Emily Christine +3 more
core +1 more source
Rae1: A new clue for nucleoporin leukemias [PDF]
Cell Cycle, 2011 N/A ; © 2011 Landes Bioscience.
Stuwe, Tobias, Hoelz, André
openaire +3 more sources
Functional insights of nucleocytoplasmic transport in plants
Frontiers in Plant Science, 2014 Plant nucleocytoplasmic transport beyond the nuclear envelope is important not only for basic cellular functions but also for growth, development, hormonal signalling, and responses to environmental stimuli.
Kentaro eTamura, Ikuko eHara-Nishimura
doaj +1 more source
An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. [PDF]
PLoS Genetics, 2017 Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive
Yingfang Zhu +8 more
doaj +1 more source
Advanced Science, EarlyView.Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu +15 more
wiley +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Prion formation by a yeast GLFG nucleoporin [PDF]
Prion, 2012 The self-assembly of proteins into higher order structures is both central to normal biology and a dominant force in disease. Certain glutamine/asparagine (Q/N)-rich proteins in the budding yeast Saccharomyces cerevisiae assemble into self-replicating amyloid-like protein polymers, or prions, that act as genetic elements in an entirely protein-based ...
Halfmann, Randal Arthur +4 more
openaire +4 more sources
Nucleoporins: leaving the nuclear pore complex for a successful mitosis.
, 2011 The nuclear envelope (NE) separates the cytoplasm and the cell nucleus of interphase eukaryotic cells and nuclear pore complexes (NPCs) mediate the macromolecular exchange between these two compartments.
Fahrenkrog, Birthe +3 more
core +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.SuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Yahongyang Lydia Li +6 more
wiley +1 more source