Results 71 to 80 of about 6,360 (219)
Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58 Form Dynamic Complexes in Solution
, 2015 Three out of ∼30 nucleoporins, Nup62, Nup54, and Nup58, line the nuclear pore channel. These “channel” nucleoporins each contain an ordered region of ∼150–200 residues, which is predicted to be segmented into 3–4 α-helical regions of ∼40–80 residues ...
Melcak, Ivo +3 more
core +1 more source
FG-nucleoporins caught in the act of liquid–liquid phase separation [PDF]
, 2019 The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol.
Dorothee Dormann, Dormann, Dorothee
core +1 more source
Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster
eLifeNuclear pore complexes (NPCs), composed of nucleoporins (Nups), affect nucleocytoplasmic transport, thus influencing cell division and gene regulation.
Jyotsna Kawadkar +2 more
doaj +1 more source
The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses
Cells, 2020 The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben +2 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson +8 more
wiley +1 more source
Linking Nucleoporins, Mitosis, and Colon Cancer [PDF]
Cell Chemical Biology, 2016 Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival.
Richard W, Wong, Maximiliano, D'Angelo
openaire +2 more sources
The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport
, 2010 The nuclear pore complex (NPC) functions as a selective gate that allows passage of certain molecules into and out of the nucleus and restricts that of others.
Sarah Wälde +3 more
core +1 more source
Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. [PDF]
, 1999 Nuclear transport factor 2 (NTF2) is a small, homodimeric protein that binds to both RanGDP and xFxFG repeat-containing nucleoporins, such as yeast Nsp1p and vertebrate p62.
Bayliss, R. +6 more
core +1 more source
Cytoskeleton, EarlyView.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source