Results 81 to 90 of about 6,360 (219)
The molecular mechanism of nuclear transport revealed by atomic-scale measurements
eLife, 2015 Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules.
Loren E Hough +7 more
doaj +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Proteomic Analysis of Nucleoporin Interacting Proteins [PDF]
Journal of Biological Chemistry, 2001 The Saccharomyces cerevisiae nuclear pore complex is a supramolecular assembly of 30 nucleoporins that cooperatively facilitate nucleocytoplasmic transport. Thirteen nucleoporins that contain FG peptide repeats (FG Nups) are proposed to function as stepping stones in karyopherin-mediated transport pathways.
N P, Allen +3 more
openaire +2 more sources
Frontiers in Microbiology, 2015 DNA viruses undertake their replication within the cell nucleus, and therefore they must first deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear envelope is at the basis of DNA virus infections.
Nikta eFay, Nelly ePante
doaj +1 more source
Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin +4 more
wiley +1 more source
Gene Regulation by Nucleoporins and Links to Cancer [PDF]
Molecular Cell, 2010 Nuclear pore complexes (NPCs) composed of approximately 30 individual nucleoporins form huge macromolecular assemblies in the nuclear envelope, through which bidirectional cargo movement between the nucleus and cytoplasm occurs. Beyond their transport function, NPCs can serve as docking sites for chromatin and thereby contribute to the organization of ...
Köhler, Alwin, Hurt, Ed
openaire +2 more sources
Systems genomics of nucleoporins provides prognostic insights into breast cancer
, 2022 Background: Nucleoporins (Nups) constitute a large group of proteins that are structurally arranged at the nuclear envelope and facilitate the bidirectional movement of molecules across the nuclear membrane.
Jibiki, Kazuya +4 more
core
Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease
NucleusNucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures ...
Junyan Lin, Izabela Sumara
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Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer
Epigenomes, 2018 Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston +1 more
doaj +1 more source
Arabidopsis TRANSCURVATA1 encodes NUP58, a component of the nucleopore central channel. [PDF]
PLoS ONE, 2013 The selective trafficking of proteins and RNAs through the nuclear envelope regulates nuclear-cytoplasmic segregation of macromolecules and is mediated by nucleopore complexes (NPCs), which consist of about 400 nucleoporins (Nups) of about 30 types ...
Almudena Ferrández-Ayela +6 more
doaj +1 more source