Results 81 to 90 of about 10,026 (221)

Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes [PDF]

, 2018
Components of the nuclear periphery coordinate a multitude of activities, including macromolecular transport, cell-cycle progression, and chromatin organization.
Acosta-Serrano A, Ahmed S, Akiyoshi B, Alexander V. Ratushny, Alsford S, Alsford S, Anne Spang, Bapteste E, Barth S, Bastin P, Brian T. Chait, Brun R, Budhraja V, Capelson M, Capitanio JS, Casolari JM, Chikne V, Clayton CE, Cronshaw JM, Daniels JP, Das A, deGrasse JA, Dieppois G, Dilworth DJ, duBois KN, Engstler M, Finn RD, Galy V, Galy V, Gravely BR, Guindon S, Gupta SK, Hirumi H, Ibarra A, Iouk T, Ishii K, Ismaïli N, Ismaïli N, Jean-Mathieu Bart, Jennifer M. Holden, John D. Aitchison, Kalverda B, Kasper LH, Katoh K, Kelly S, Kolev NG, Kramer S, Krull S, Kurshakova MM, Landeira D, Li H, Liang XH, Liang Y, Light WH, Ludek Koreny, Manger ID, Mark C. Field, Menon BB, Michael P. Rout, Miguel Navarro, Morchoisne-Bolhy S, Navarro M, Neumann N, Obado S, Oberholzer M, Ouellette M, Palenchar JB, Park JH, Rasband WS, Rout MP, Samson Obado, Schindelin J, Schwede A, Schwede A, Stanne TM, Tous C, Trapnell C, Utter CJ, Vaquerizas JM, Vassella E, Wei-Ming Chen, Wirtz E, Xu H, Yang X   +83 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Nucleoporin-mediated regulation of cell identity genes [PDF]

Genes & Development, 2016
The organization of the genome in the three-dimensional space of the nucleus is coupled with cell type-specific gene expression. However, how nuclear architecture influences transcription that governs cell identity remains unknown. Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 bind superenhancers (SE), regulatory structures ...
Ibarra, Arkaitz, Benner, Chris, Tyagi, Swati, Cool, Jonah, Hetzer, Martin W   +4 more
openaire   +4 more sources

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

eLife, 2015
Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules.
Loren E Hough, Kaushik Dutta, Samuel Sparks, Deniz B Temel, Alia Kamal, Jaclyn Tetenbaum-Novatt, Michael P Rout, David Cowburn   +7 more
doaj   +1 more source

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr [PDF]

, 2009
Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Iris Ben-Efraim, Phyllis D Frosst, Larry Gerace   +2 more
core   +2 more sources

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

A mosaic of old and young nucleoporins [PDF]

Journal of Cell Biology, 2019
Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in ...
Takeshi Shimi, Hiroshi Kimura
openaire   +2 more sources

Nuclear entry of DNA viruses

Frontiers in Microbiology, 2015
DNA viruses undertake their replication within the cell nucleus, and therefore they must first deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear envelope is at the basis of DNA virus infections.
Nikta eFay, Nelly ePante
doaj   +1 more source

Arabidopsis TRANSCURVATA1 encodes NUP58, a component of the nucleopore central channel. [PDF]

PLoS ONE, 2013
The selective trafficking of proteins and RNAs through the nuclear envelope regulates nuclear-cytoplasmic segregation of macromolecules and is mediated by nucleopore complexes (NPCs), which consist of about 400 nucleoporins (Nups) of about 30 types ...
Almudena Ferrández-Ayela, María Magdalena Alonso-Peral, Ana Belén Sánchez-García, Rosa Micol-Ponce, José Manuel Pérez-Pérez, José Luis Micol, María Rosa Ponce   +6 more
doaj   +1 more source

RNA Nuclear Export: From Neurological Disorders to Cancer [PDF]

, 2017
The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place ...
Hautbergue, G.M.
core   +1 more source