Results 101 to 110 of about 6,849 (214)

Biomimetic Nanopores with Yeast Nucleoporins

, 2014
Nuclear pore complexes (NPC’s) facilitate the exchange of macromolecules between the cytoplasm and nucleus and act as a selective barrier for macromolecules in eukaryotes. Ongoing research suggests that the discriminatory function of the NPC is caused by
Dwarkasing, Arvind (author)
core  

Characterization of the role of the tumor marker Nup88 in mitosis

Molecular Cancer, 2010
Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup).
Yoshida Kimihisa, Nakano Hiroshi, Hashizume Chieko, Wong Richard W   +3 more
doaj   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Nucleoporins interacting with MX2 are located at the cytoplasmic face of the nuclear pore.

, 2018
Schematic diagram indicating the structure and organization of the nuclear pore complex as described in Hoelz et al [22]. Nucleoporins interacting with MX2 (identified by Y-2-H screening) are shown in red.
Gilberto Betancor (6029015), Matthew D. J. Dicks (151161), Lucie Pessel-Vivares (6029018), Caroline Goujon (6029021), Jose M. Jimenez-Guardeño (5658871), Luis Apolonia (684101), Michael H. Malim (195728)   +6 more
core   +1 more source

Decoding the Regulatory Logic of the Drosophila Male Stem Cell System

Cell Reports, 2018
Summary: The niche critically controls stem cell behavior, but its regulatory input at the whole-genome level is poorly understood. We elucidated transcriptional programs of the somatic and germline lineages in the Drosophila testis and genome-wide ...
Srividya Tamirisa, Fani Papagiannouli, Eugen Rempel, Olga Ermakova, Nils Trost, Jun Zhou, Juliane Mundorf, Samantha Brunel, Naima Ruhland, Michael Boutros, Jan U. Lohmann, Ingrid Lohmann   +11 more
doaj   +1 more source

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

eLife, 2016
Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk, Chad Gu, Michael G Opferman, Larisa E Kapinos, Roderick YH Lim, Rob D Coalson, David Jasnow, Anton Zilman   +7 more
doaj   +1 more source

Bending or Building: Multifaceted Functions of Amphipathic Helices in Basket Nucleoporins.

, 2015
International audienceRecently reporting in Developmental Cell, Mészáros et al. (2015) and Vollmer et al. (2015) extend the inventory of membrane-binding and -bending nuclear pore proteins to peripheral nucleoporins localized at the nuclear ...
Doye, Valérie, Souquet, Benoit, Valérie Doye, Benoit Souquet   +3 more
core   +1 more source

NUP155 and NDC1 interaction in NSCLC: a promising target for tumor progression

Frontiers in Pharmacology
BackgroundNUP155 was reported to involve breast invasive carcinoma and hepatocellular carcinoma. We hypothesized that NUP155 and NDC1impacted the progression of NSCLC.MethodsThe dataset was analyzed to find differentially expressed genes.
Kai-Min Li, Li-Fei Meng, Zhi-Hao Yang, Wen-Tao Hu   +3 more
doaj   +1 more source

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

Nature Communications, 2020
The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory
Shinichi Kadota, Jianhong Ou, Yuming Shi, Jeannie T. Lee, Jiayu Sun, Eda Yildirim   +5 more
doaj   +1 more source

Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β

, 2012
The mechanism for nuclear envelope (NE) assembly is not fully understood. Importin-ß and the small GTPase Ran have been implicated in the spatial regulation of NE assembly process.
Guo, Li, Liu, Qinying, He Ren, Zhigang Lu, Lu, Quanlong, Qinying Liu, Jiang, Qing, Lu, Zhigang, Zhang, Chuanmao, Fu, Jingyan, Jingyan Fu, Ren, He, Paul R Clarke, Quanlong Lu, Li Guo, Qing Jiang, Chuanmao Zhang, Clarke, Paul R.   +17 more
core   +1 more source