Results 101 to 110 of about 6,360 (219)

Co-translational assembly orchestrates competing biogenesis pathways

Nature Communications, 2022
The biogenesis of nuclear pores imposes a logistic challenge for cells. Here, the authors investigate structural motifs for co-translational interactions in nucleoporins and find that co-translational assembly events differ between paralogous assembly ...
Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Claudia M. Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian D. Langer, Erin M. Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, Martin Beck   +14 more
doaj   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Nucleoporin Gene Fusions and Hematopoietic Malignancies [PDF]

New Journal of Science, 2014
Nuclear pore complexes (NPCs) are the sole gateways between the nucleus and the cytoplasm of eukaryotic cells and they mediate all macromolecular trafficking between these cellular compartments. Nucleocytoplasmic transport is highly selective and precisely regulated and as such an important aspect of normal cellular function. Defects in this process or
openaire   +2 more sources

NLS‐mediated NPC functions of the nucleoporin Pom121 [PDF]

FEBS Letters, 2010
MINT‐7951306, MINT‐7951362: pom121 (uniprotkb:Q5EWX9) physically interacts (MI:0914) with nup155 (uniprotkb:Q7ZWL0), nup160 (uniprotkb:P83722), nup93 (uniprotkb:Q7ZX96), Importin beta (uniprotkb:P52297) and nup62 (uniprotkb:Q91349) by pull down (MI:0096)
Yavuz, Sevil, Santarella-Mellwig, Rachel, Koch, Birgit, Jaedicke, Andreas, Mattaj, Iain W., Antonin, Wolfram   +5 more
openaire   +2 more sources

Selective recruitment of nucleoporins on vaccinia virus factories and the role of Nup358 in viral infection

, 2017
Vaccinia virus (VACV), a member of the Poxviridae family, uses cytoplasmic factories for its replication. Recent studies indicated that VACV infection requires a set of nucleoporins.
Ashish Kamble, Renuka Nawadkar, Arvind Sahu, Singh, Aditi, Sahu, Arvind, Khuperkar, Deepak, Aditi Singh, Arya Ghate, Deepak Khuperkar, Kamble, Ashish, Ghate, Arya, Jomon Joseph, Nawadkar, Renuka, Joseph, Jomon   +13 more
core   +1 more source

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
wiley   +1 more source

Nucleoporins interacting with MX2 are located at the cytoplasmic face of the nuclear pore.

, 2018
Schematic diagram indicating the structure and organization of the nuclear pore complex as described in Hoelz et al [22]. Nucleoporins interacting with MX2 (identified by Y-2-H screening) are shown in red.
Gilberto Betancor (6029015), Matthew D. J. Dicks (151161), Lucie Pessel-Vivares (6029018), Caroline Goujon (6029021), Jose M. Jimenez-Guardeño (5658871), Luis Apolonia (684101), Michael H. Malim (195728)   +6 more
core   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Uncovering moonlighting functions of nucleoporins across species

, 2023
Trabajo presentado en la 24th International C.elegans Conference, celebrada en Glasgow (Escocia) del 24 al 28 de junio de 2023.Nuclear pore complexes (NPCs) are composed of multiple copies of 30-35 nucleoporins (Nups; NPPs in C.
Rodríguez Daga, Rafael, Ayuso, Cristina, Monterrubio Asensio, Paula, Askjaer, Peter   +3 more
core  

Transmembrane Protein GbTMEM209 Inhibits Fibre Elongation via Competitive Interaction With GbHOX3 in Gossypium barbadense

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3087-3105, May 2026.
ABSTRACT Sea Island cotton (Gossypium barbadense) produces premium‐quality fibres, yet the genetic basis underlying its fibre development remains elusive. Here, we identify two key non‐synonymous single nucleotide polymorphisms (SNPs, G/C and G/A) in the gene Gbar_D13G024080, which encodes the TRANSMEMBRANE PROTEIN 209 (TMEM209). These SNPs resulted in
Kaiyun Jiang, Nan Zhao, Jie Kong, Anhui Guo, Yuqi Liu, Meng Wang, Zixin Zhou, Mengling Sun, Weiran Wang, Jiahui Zhu, Daojun Yuan, Zhuanxia Pan, Pengbo Li, Suen Liu, Baosheng Guo, Huijing Li, Jingrou Zhang, Bin Li, Zhanghao Xia, Beibei Lv, Junyi Geng, Baoliang Wang, Alifu Aierxi, Xianlong Zhang, Lili Tu, Jinping Hua   +25 more
wiley   +1 more source