Results 101 to 110 of about 10,026 (221)

Specific Nucleoporin Requirement for Smad Nuclear Translocation [PDF]

Molecular and Cellular Biology, 2010
Cytoplasm-to-nucleus translocation of Smad is a fundamental step in transforming growth factor beta (TGF-beta) signal transduction. Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but not the constitutive import of ...
Xiaochu, Chen, Lan, Xu
openaire   +2 more sources

NUP155 and NDC1 interaction in NSCLC: a promising target for tumor progression

Frontiers in Pharmacology
BackgroundNUP155 was reported to involve breast invasive carcinoma and hepatocellular carcinoma. We hypothesized that NUP155 and NDC1impacted the progression of NSCLC.MethodsThe dataset was analyzed to find differentially expressed genes.
Kai-Min Li, Li-Fei Meng, Zhi-Hao Yang, Wen-Tao Hu   +3 more
doaj   +1 more source

A comparison between nuclear dismantling during plant and animal programmed cell death [PDF]

, 2012
Programmed cell death (PCD) is a process of organized destruction of cells, essential for the development and maintenance of cellular homeostasis of multicellular organisms.
Cejudo Fernández, Francisco Javier, Domínguez del Toro, Fernando   +1 more
core   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Co-translational assembly orchestrates competing biogenesis pathways

Nature Communications, 2022
The biogenesis of nuclear pores imposes a logistic challenge for cells. Here, the authors investigate structural motifs for co-translational interactions in nucleoporins and find that co-translational assembly events differ between paralogous assembly ...
Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Claudia M. Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian D. Langer, Erin M. Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, Martin Beck   +14 more
doaj   +1 more source

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

Transmembrane Protein GbTMEM209 Inhibits Fibre Elongation via Competitive Interaction With GbHOX3 in Gossypium barbadense

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3087-3105, May 2026.
ABSTRACT Sea Island cotton (Gossypium barbadense) produces premium‐quality fibres, yet the genetic basis underlying its fibre development remains elusive. Here, we identify two key non‐synonymous single nucleotide polymorphisms (SNPs, G/C and G/A) in the gene Gbar_D13G024080, which encodes the TRANSMEMBRANE PROTEIN 209 (TMEM209). These SNPs resulted in
Kaiyun Jiang, Nan Zhao, Jie Kong, Anhui Guo, Yuqi Liu, Meng Wang, Zixin Zhou, Mengling Sun, Weiran Wang, Jiahui Zhu, Daojun Yuan, Zhuanxia Pan, Pengbo Li, Suen Liu, Baosheng Guo, Huijing Li, Jingrou Zhang, Bin Li, Zhanghao Xia, Beibei Lv, Junyi Geng, Baoliang Wang, Alifu Aierxi, Xianlong Zhang, Lili Tu, Jinping Hua   +25 more
wiley   +1 more source

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity [PDF]

Cell, 2002
Posttranslational modification with SUMO1 regulates protein/protein interactions, localization, and stability. SUMOylation requires the E1 enzyme Aos1/Uba2 and the E2 enzyme Ubc9. A family of E3-like factors, PIAS proteins, was discovered recently. Here we show that the nucleoporin RanBP2/Nup358 also has SUMO1 E3-like activity.
Pichler, Andrea, Gast, Andreas, Seeler, Jacob-Sebastian, Dejean, Anne, Melchior, Frauke   +4 more
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, Volume 600, Issue 7, Page 1028-1042, April 2026.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Identification of a Novel, Oncogenic and Targetable TPR::ABL2 Fusion Gene in T‐Cell Acute Lymphoblastic Leukaemia

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT ABL2 rearrangements represent a subtype of acute lymphoblastic leukaemia (ALL) associated with poor prognosis and survival. This study reports a high‐risk T‐cell ALL (T‐ALL) case with a novel TPR::ABL2 gene fusion resulting from a chromosomal deletion.
Elias Lagonik, Elyse. C. Page, Laura N. Eadie, Caitlin E. Schutz, Jacqueline A. Rehn, Susan L. Heatley, Andrew S. Moore, Muirin Healy, Morag Whyte, Timothy P. Hughes, David T. Yeung, Deborah L. White   +11 more
wiley   +1 more source