Results 111 to 120 of about 6,360 (219)
Decoding the Regulatory Logic of the Drosophila Male Stem Cell System
Cell Reports, 2018 Summary: The niche critically controls stem cell behavior, but its regulatory input at the whole-genome level is poorly understood. We elucidated transcriptional programs of the somatic and germline lineages in the Drosophila testis and genome-wide ...
Srividya Tamirisa +11 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, Volume 600, Issue 7, Page 1028-1042, April 2026.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
RIF1 AND NUCLEOPORINS PROMOTE THE CHROMATIN ASSOCIATION OF ORC
, 2023 Accurate duplication of the genome is critical to maintain genomic stability and failures in DNA replication can result in a host of diseases. DNA replication is a coordinated and tightly regulated process; however, much remains unknown regarding exactly
Richards, Logan
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eJHaem, Volume 7, Issue 2, April 2026.ABSTRACT ABL2 rearrangements represent a subtype of acute lymphoblastic leukaemia (ALL) associated with poor prognosis and survival. This study reports a high‐risk T‐cell ALL (T‐ALL) case with a novel TPR::ABL2 gene fusion resulting from a chromosomal deletion.
Elias Lagonik +11 more
wiley +1 more source
The nucleoporin Nup88 is interacting with nuclear lamin A
Molecular Biology of the Cell, 2011 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) and mediate bidirectional nucleocytoplasmic transport. Their spatial distribution in the NE is organized by the nuclear lamina, a meshwork of nuclear intermediate filament proteins. Major constituents of the nuclear lamina are A- and B-type lamins.
Lussi, Yvonne Y.C. +4 more
openaire +6 more sources
Biomimetic Nanopores with Yeast Nucleoporins
, 2014 Nuclear pore complexes (NPC’s) facilitate the exchange of macromolecules between the cytoplasm and nucleus and act as a selective barrier for macromolecules in eukaryotes. Ongoing research suggests that the discriminatory function of the NPC is caused by
Dwarkasing, Arvind (author)
core
Characterization of the role of the tumor marker Nup88 in mitosis
Molecular Cancer, 2010 Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup).
Yoshida Kimihisa +3 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 8, Page 2159-2177, April 2026.Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets +2 more
wiley +1 more source
eLife, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk +7 more
doaj +1 more source
Regulation of nucleoporins in mitosis
, 2007 Nucleoporins mediate nucleocytoplasmic trafficking in interphase. In mitosis, upon nuclear envelope breakdown, the role and regulation of Nups remain to be elucidated.
Chakraborty, Papia
core