Results 41 to 50 of about 16,651 (218)
Quantification of the SG association for importin-α1, α4, α5 and importin-β1.
, 2013 HeLa cells were incubated with DEM, arsenite or heat shock and stained with antibodies against importin-α1, α4, α5, or importin-β1. SGs were identified with the marker protein HuR, and 30 SG-containing cells were evaluated for every treatment.
Dekun Kong (427450) +3 more
core +1 more source
Acta Pharmaceutica Sinica B, 2023 Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many cancers. However, the lack of druggable inhibitors restricts its therapeutic proof of concept. In the present work, we optimized a natural importin-β1
Jia-Luo Huang +12 more
doaj +1 more source
Advanced Science, EarlyView.A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo +13 more
wiley +1 more source
Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
openaire +2 more sources
Importin beta validates human importin beta as a cell cycle negative regulator-3
, 2011 D importin beta were not able to assemble nuclear pores (+Tag-X-β). When RanQ69L-GTP was added along with His-tagged importin beta, the block to pore assembly could not be reversed (+Tag-X-β +Ran).
Rene C Chan (63112) +2 more
core +1 more source
Advanced Science, EarlyView.ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang +9 more
wiley +1 more source
Conserved arginines of bovine adenovirus-3 33K protein are important for transportin-3 mediated transport and virus replication. [PDF]
PLoS ONE, 2014 The L6 region of bovine adenovirus (BAdV)-3 encodes a spliced protein designated 33K. The 33K specific sera detected five major proteins and three minor proteins in transfected or virus infected cells, which could arise by internal initiation of ...
Vikas Kulshreshtha +3 more
doaj +1 more source
Enforced Unfolding and Mechanical Properties of the Importin-Beta and Importin-Beta-Binding-Domain Complex [PDF]
Biophysical Journal, 2013 Importin-beta plays an important role in material exchange between the cell nucleus and the cytoplasm. In order to transport large molecules through the nuclear pore complex it has to bind tightly to the importin-beta-binding (IBB) domain of its cargo.To probe the mechanical properties of this binding, enforced unbinding was investigated by single ...
Russek, A., Grubmüller, H.
openaire +3 more sources
Advanced Science, EarlyView.SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng +18 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the host ...
Yuri Kim +6 more
doaj +1 more source