UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. [PDF]
PLoS ONE, 2013 Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase.
Zhengke Li +4 more
doaj +1 more source
Journal of Biomolecular Structure and Dynamics, 2020 While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by ∼5000 folds within 48 h, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro effective drug ...
Parth Sarthi Sen Gupta +4 more
semanticscholar +1 more source
Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]
PLoS ONE, 2017 The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston +2 more
doaj +1 more source
Identification and Characterization of Importin 13 Substrates [PDF]
, 2017 Nuclear pore complexes embedded in the nuclear envelope regulate the bidirectional transport of macromolecules between the nucleus and the cytoplasm. Small molecules can rapidly move through the permeability barrier of the nuclear pore complex, whereas ...
Baade, Imke
core +1 more source
Importin-α2 mediates brain development, learning and memory consolidation in Drosophila
, 2020 Neuronal development and memory consolidation are conserved processes that rely on nuclear-cytoplasmic transport of signaling molecules to regulate gene activity and initiate cascades of downstream cellular events.
Stephanie Freer (8343204) +7 more
core +1 more source
Indonesian Journal of Biotechnology, 2005 Isoform importin α molecules play a central role in the classical nuclear import pathway, that occurs through the nuclear pore complex (NPC) and typically requires a specific nuclear localization signal (NLS).
Aris Haryanto
doaj +1 more source
Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. [PDF]
PLoS ONE, 2011 The signal transducer and activator of transcription-3 (STAT3) induces transcription of genes that control differentiation, inflammation, proliferation, and tumor cell invasion.
Velasco Cimica +3 more
doaj +1 more source
Importin-α-mediated nucleolar localization of potato mop-top virus TRIPLE GENE BLOCK1 (TGB1) protein facilitates virus systemic movement, whereas TGB1 self-interaction is required for cell-to-cell movement in Nicotiana benthamiana [PDF]
, 2015 This work was supported by the Swedish Research Council Formas (to E.I.S.), the Carl Tryggers Foundation (to E.I.S. and N.I.L.), the Swedish Institute (to N.I.L.), and the Rural and Environmental Science and Analytical Services Division strategic ...
Savenkov, Eugene I. +5 more
core +1 more source
Importin α7 is essential for zygotic genome activation and early mouse development. [PDF]
PLoS ONE, 2011 Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood.
Franziska Rother +11 more
doaj +1 more source
Biology, 2020 One of the most conserved cellular pathways among eukaryotes is the extensively studied classical protein nuclear import pathway mediated by importin-α.
Tanner M. Tessier +2 more
doaj +1 more source