Results 51 to 60 of about 21,607 (213)
Nuclear transport maintenance of USP22-AR by Importin-7 promotes breast cancer progression
Cell Death Discovery, 2023 The translocation of biological macromolecules between cytoplasm and nucleus is of great significance to maintain various life processes in both normal and cancer cells.
Geng-Xi Cai +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation.
Robert F. Candia +7 more
doaj +1 more source
Importin binding mediates the intramolecular regulation of anillin during cytokinesis
Molecular Biology of the Cell, 2020 Cytokinesis occurs by the ingression of an actomyosin ring that cleaves a cell into two daughters. This process is tightly controlled to avoid aneuploidy, and we previously showed that active Ran coordinates ring positioning with chromatin. Active Ran is
Daniel Beaudet +3 more
semanticscholar +1 more source
bioRxiv, 2020 IMPORTIN-α3/MOS6 (MODIFIER OF SNC1, 6) is one of nine importin-α isoforms in Arabidopsis that recruit nuclear localization signal (NLS)-containing cargo proteins to the nuclear import machinery.
Daniel Lüdke +12 more
semanticscholar +1 more source
Subcellular Localization of Epstein–Barr Virus BLLF2 and Its Underlying Mechanisms
Frontiers in Microbiology, 2021 Epstein–Barr virus (EBV), the pathogen of several human malignancies, encodes many proteins required to be transported into the nucleus for viral DNA reproduction and nucleocapsids assembly in the lytic replication cycle.
Jingjing Li +13 more
doaj +1 more source
Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells
bioRxiv, 2020 Germ cells undergo distinct nuclear processes as they differentiate into gametes. While these events must be coordinated to ensure proper maturation, the stage-specific transport of proteins in and out of germ cell nuclei remains incompletely understood.
Victor Palacios +3 more
semanticscholar +1 more source
PLoS ONE, 2015 In this study, we determined the crystal structure of N-terminal importin-β-binding domain (IBB)-truncated human importin-α1 (ΔIBB-h-importin-α1) at 2.63 Å resolution. The crystal structure of ΔIBB-h-importin-α1 reveals a novel closed homodimer.
Hideyuki Miyatake +7 more
doaj +1 more source
A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
eLife, 2022 Core histones package chromosomal DNA and regulate genomic transactions, with their nuclear import and deposition involving importin-β proteins and a dedicated repertoire of histone chaperones. Previously, a histone H3-H4 dimer has been isolated bound to
Alonso Javier Pardal +1 more
doaj +1 more source
NF-κB is transported into the nucleus by importin α3 and importin α4
, 2005 NF-{kappa}B transcription factors are retained in the cytoplasm in an inactive form until they are activated and rapidly imported into the nucleus. We identified importin {alpha}3 and importin {alpha}4 as the main importin {alpha} isoforms mediating TNF-{
Koehler, M. +4 more
core +1 more source
Importin α: functions as a nuclear transport factor and beyond
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2018 Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular mechanisms underlying nuclear transport that involve the nuclear transport receptor, small GTPase Ran, and the nuclear pore complex are highly conserved from yeast to humans.
M. Oka, Y. Yoneda
semanticscholar +1 more source