Results 51 to 60 of about 16,651 (218)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

The Ran importin system in cilia trafficking [PDF]

Organogenesis, 2011
Cilia are microtubule-based organelles that arise from the centrosome and project from the surface of many cells. Defects in cilia-localized proteins are felt to lead to polycystic kidney disease as well as ciliopathies with multiple organ involvement.
Shuling, Fan, Ben, Margolis
openaire   +2 more sources

Importin-α4 and importin-α7 form complexes with XPA in cells.

, 2013
A. XPA was detected in the protein complexes of importin-α4 or importin-α7 by Western blotting. Immunoprecipitation of importin-α4 or importin-α7 also pulled down XPA in lysates from H1299 cells which were UV-C irradiated (20 J/m2) and allowed a ½ h ...
Hui Wang (30400), Phillip R. Musich (337656), Yue Zou (15851), Zhengke Li (337655), Brian M. Cartwright (431428)   +4 more
core   +1 more source

Biophysical characterization of interactions involving importin-alpha during nuclear import [PDF]

, 2001
Proteins containing the classical nuclear localization sequences (NLSs) are imported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha contains the NLS binding site, whereas importin-beta mediates the translocation through the ...
Jennings, I. G., Jenning, Ian G, Kobe, Bostjan, Howlett, Geoffrey, Jennings, Ian G., Fontes, M. R. M., Jans, D. A., Nice, Edouard C., Kobe, B., Howlett, G. J., Catimel, B., Howlett, Geoffrey J., Fontes, Marcos, Fontes, Marcos R. M., Teh, T., Catimel, Bruno, Jans, David A., Nice, E. C., Jans, David A, Teh, Trazel, Fontes, Marcos R. M. [UNESP], Nice, Edouard C   +21 more
core   +1 more source

Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin

Pathogens, 2021
Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs.
Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, Grégory Caignard, Damien Vitour, Jennifer Richardson, Sandrine Lacour, Houssam Attoui, Lesley Bell-Sakyi, Eleonore Allain, Ard M. Nijhof, Nina Militzer, Sophia Pinecki Socias, José de la Fuente   +13 more
doaj   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice

Frontiers in Neuroscience, 2022
Importin α3 (Gene: Kpna3, the ortholog of human Importin α4) is a member of the importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins and importin β1.
Yoshiatsu Aomine, Yoshiatsu Aomine, Koki Sakurai, Koki Sakurai, Tom Macpherson, Tom Macpherson, Takaaki Ozawa, Takaaki Ozawa, Yoichi Miyamoto, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida, Takatoshi Hikida   +12 more
doaj   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Importin beta validates human importin beta as a cell cycle negative regulator-2

, 2011
Ontain no nuclear pores (left panel), when diluted into fresh cytosol (+ buffer), incorporate nuclear pores. The addition of His-tagged human importin beta (+h-β-Tag) or untagged importin beta (+X-β) prevented nuclear pore assembly.
Rene C Chan (63112), Valerie A Delmar (63111), Douglass J Forbes (63113)   +2 more
core   +1 more source