Results 51 to 60 of about 29,175 (219)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer

Acta Pharmaceutica Sinica B, 2023
Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many cancers. However, the lack of druggable inhibitors restricts its therapeutic proof of concept. In the present work, we optimized a natural importin-β1
Jia-Luo Huang, Xue-Long Yan, Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang, Sheng Yin   +12 more
doaj   +1 more source

Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1

Molecular and Cellular Endocrinology, 2016
The thyroid hormone receptor α1 (TRα1) is a nuclear receptor for thyroid hormone that shuttles rapidly between the nucleus and cytoplasm. Our prior studies showed that nuclear import of TRα1 is directed by two nuclear localization signals, one in the N-terminal A/B domain and the other in the hinge domain.
Vincent R, Roggero, Jibo, Zhang, Laura E, Parente, Yazdi, Doshi, Rose C, Dziedzic, Emma L, McGregor, Arev D, Varjabedian, Sara E, Schad, Cornelius, Bondzi, Lizabeth A, Allison   +9 more
openaire   +3 more sources

NF-κB Is Transported into the Nucleus by Importin α3 and Importin α4 [PDF]

Journal of Biological Chemistry, 2005
NF-κB transcription factors are retained in the cytoplasm in an inactive form until they are activated and rapidly imported into the nucleus. We identified importin α3 and importin α4 as the main importin α isoforms mediating TNF-α-stimulated NF-κB p50/p65 heterodimer translocation into the nucleus.
Riku Fagerlund, Leena Kinnunen, Matthias Köhler, Ilkka Julkunen, Krister Melén   +4 more
openaire   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts

Virulence, 2018
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear ...
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu   +8 more
doaj   +1 more source

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly [PDF]

, 2019
Importin-α serves as an adaptor linking importin-β to proteins carrying a nuclear localization sequence (NLS). During interphase, this interaction enables nuclear protein import, while in mitosis it regulates spindle assembly factors (SAFs) and controls ...
Alfonso-Pérez, Askjaer, Bamba, Bentley, Bian, Bischoff, Bischoff, Caudron, Chen, Ciciarello, Cingolani, Clarke, Conti, Conti, Fu, Fu, Garrett, Giesecke, Gilistro, Gruss, Gruss, Heald, Hornbeck, Hutchins, Johnson, Kaláb, Kaláb, Kinoshita, Kobe, Kufer, Li, Lu, Mayer, Moore, Mountain, Musacchio, Nachury, Nigg, Petry, Pumroy, Sankhala, Schatz, Silljé, Swaminathan, Trieselmann, Whitfield, Wiese, Wittmann, Wu, Zhu   +49 more
core   +2 more sources

Vascular miR‐181b controls tissue factor‐dependent thrombogenicity and inflammation in type 2 diabetes [PDF]

, 2020
BACKGROUND: Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes factor (
Chakraborty, Aritra, Dörner, Andrea, Friebel, Julian, Krueger, Andreas, Landmesser, Ulf, Rauch, Ursula, Ruf, Wolfram, Saffarzadeh, Mona, Stratmann, Bernd, Ta Bao, Loc, Tabaraie, Termeh, Tschoepe, Diethelm, Winter, Samantha J., Witkowski, Marco, Witkowski, Mario   +14 more
core   +1 more source

Conformational Selection in the Recognition of the Snurportin Importin β Binding Domain by Importin β [PDF]

Biochemistry, 2010
The structural flexibility of beta-karyopherins is critical to mediate the interaction with transport substrates, nucleoporins, and the GTPase Ran. In this paper, we provide structural evidence that the molecular recognition of the transport adaptor snurportin by importin beta follows the population selection mechanism. We have captured two drastically
Anshul, Bhardwaj, Gino, Cingolani
openaire   +2 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source