Results 31 to 40 of about 29,175 (219)

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Nature Communications, 2022
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri, Miguel A. Del Pozo   +12 more
doaj   +1 more source

Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome

Biology, 2020
One of the most conserved cellular pathways among eukaryotes is the extensively studied classical protein nuclear import pathway mediated by importin-α.
Tanner M. Tessier, Katelyn M. MacNeil, Joe S. Mymryk   +2 more
doaj   +1 more source

Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]

, 2020
The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I., Geiss, C., Kondo, H., Lenart, P., Machado, P., Mori, M., Wesolowska, N.   +6 more
core   +1 more source

Importin α7 is essential for zygotic genome activation and early mouse development. [PDF]

PLoS ONE, 2011
Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood.
Franziska Rother, Tatiana Shmidt, Elena Popova, Alexander Krivokharchenko, Stefanie Hügel, Larissa Vilianovich, Michael Ridders, Katja Tenner, Natalia Alenina, Matthias Köhler, Enno Hartmann, Michael Bader   +11 more
doaj   +1 more source

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Nature Communications, 2017
Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α ...
Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, Gino Cingolani   +5 more
doaj   +1 more source

Nuclear transport maintenance of USP22-AR by Importin-7 promotes breast cancer progression

Cell Death Discovery, 2023
The translocation of biological macromolecules between cytoplasm and nucleus is of great significance to maintain various life processes in both normal and cancer cells.
Geng-Xi Cai, Wei-Yao Kong, Yuan Liu, Shu-Yi Zhong, Qing Liu, Yuan-Fei Deng, Guo-Lin Ye   +6 more
doaj   +1 more source

Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death

Frontiers in Molecular Neuroscience, 2022
Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation.
Robert F. Candia, Robert F. Candia, Leah S. Cohen, Viktoriya Morozova, Viktoriya Morozova, Christopher Corbo, Alejandra D. Alonso, Alejandra D. Alonso   +7 more
doaj   +1 more source

Structural insight into TPX2-stimulated microtubule assembly [PDF]

, 2017
During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2.
Nogales, Eva, Roostalu, Johanna, Surrey, Thomas, Zhang, Rui   +3 more
core   +2 more sources

Importins and exportins in cellular differentiation [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Importins and exportins NLS and NES Cargo molecules Importins and exportins In cellular differentiation Concluding remarks AbstractThe importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport.
Okada, Norihisa, Ishigami, Yoko, Suzuki, Takuji, Kaneko, Akihiro, Yasui, Kensuke, Fukutomi, Ryuuta, Isemura, Mamoru   +6 more
openaire   +2 more sources