Results 31 to 40 of about 21,607 (213)

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

Nature Communications, 2021
The importin superfamily member Importin-13 is a bidirectional nuclear transporter. To delineate its functional roles, we performed transcriptomic analysis on wild-type and Importin-13-knockout mouse embryonic stem cells, revealing enrichment of ...
K. Gajewska, H. Lescesen, M. Ramialison, K. Wagstaff, D. Jans   +4 more
semanticscholar   +1 more source

Importin-αs are required for the nuclear localization and function of the Plasmopara viticola effector PvAVH53

Horticulture Research, 2021
Plant pathogenic oomycetes deliver a troop of effector proteins into the nucleus of host cells to manipulate plant cellular immunity and promote colonization.
Tingting Chen, Jing Peng, Xiao Yin, Meijie Li, Gaoqing Xiang, Yuejin Wang, Y. Lei, Yan Xu   +7 more
semanticscholar   +1 more source

Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association [PDF]

, 2000
A heterodimer of importin alpha and importin beta accomplishes the nuclear import of proteins carrying classical nuclear localization signals (NLS).
Gerace, L., Cingolani, G., Lashuel, H. A., Müller, C. W.   +3 more
core   +4 more sources

Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. [PDF]

PLoS ONE, 2013
BACKGROUND:Importin-α1 belongs to a subfamily of nuclear transport adaptors and participates in diverse cellular functions. Best understood for its role in protein transport, importin-α1 also contributes to other biological processes.
Hicham Mahboubi, Evangeline Seganathy, Dekun Kong, Ursula Stochaj   +3 more
doaj   +1 more source

Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targets

Journal of Biomolecular Structure and Dynamics, 2021
Ivermectin (IVM) is an FDA-approved drug that has shown antiviral activity against a wide variety of viruses in recent years. IVM inhibits the formation of the importin-α/β1 heterodimeric complex responsible for the translocation and replication of ...
M. Bello
semanticscholar   +1 more source

Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation

Journal of Cell Science, 2021
Spindle orientation is important in multiple developmental processes as it determines cell fate and function. The orientation of the spindle depends on the assembly of a proper astral microtubule network.
Haijing Guo, Jen-Hsuan Wei, Yi-Jun Zhang, J. Seemann   +3 more
semanticscholar   +1 more source

Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal

Data in Brief, 2023
53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein ...
Yoshiyuki Matsuura
doaj   +1 more source

USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2

Journal of Experimental Medicine, 2020
USP22 is a cytoplasmic and nuclear deubiquitinating enzyme. Cai et al. show that the cytoplasmic USP22 deubiquitinates and stabilizes the importin protein KPNA2 after viral infection, which promotes nuclear translocation of IRF3 and cellular antiviral ...
Zeng Cai, Meng-Xin Zhang, Zhen Tang, Qiang Zhang, Jing Ye, Tianchen Xiong, Zhi-Dong Zhang, Bo Zhong   +7 more
semanticscholar   +1 more source

The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation. [PDF]

PLoS ONE, 2013
The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation.
Nalani Sachan, Abhinava K Mishra, Mousumi Mutsuddi, Ashim Mukherjee   +3 more
doaj   +1 more source

Xenopus importin beta validates human importin beta as a cell cycle negative regulator

BMC Cell Biology, 2008
Background Human importin beta has been used in all Xenopus laevis in vitro nuclear assembly and spindle assembly studies. This disconnect between species raised the question for us as to whether importin beta was an authentic negative regulator of cell ...
Forbes Douglass J, Chan Rene C, Delmar Valerie A   +2 more
doaj   +1 more source