Viruses, 2021 The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly
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Nuclear Import of Yeast Proteasomes [PDF]
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
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Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. [PDF]
PLoS Pathogens, 2017 The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated ...
Ryan C Burdick +6 more
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Direct visualization of HIV-1 core nuclear import and its interplay with the nuclear pore [PDF]
EMBO ReportsDirect visualization of HIV-1 nuclear import through the nuclear pore complex (NPC) presents a technical challenge due to the rarity of this process.
Zhen Hou +6 more
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tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes.
PLoS Biology, 2006 Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Lyubov Zaitseva +2 more
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Inhibition of nuclear import suppresses androgen receptor action and overcomes resistance in prostate cancer [PDF]
BMC CancerBackground Androgen deprivation and androgen receptor (AR) antagonists are essential treatments for prostate cancers in the clinic. However, after an initially effective response, most tumors become resistant to androgen deprivation therapies. Resistance
Xuan Wang +4 more
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Structural and functional characterisation of ATF2 nuclear import reveals paralogue-selective importin-α recognition and a non-canonical NLS formed in trans [PDF]
Life Science AllianceATF2 enters the nucleus via importin-α/β1 using two basic clusters that bind major and minor sites of importin-α1. Structural and cell data reveal redundancy, CRM1 export, and c-Jun–assisted co-import. Activating transcription factor 2 (ATF2) is a member
Seyed Mohammad Ghafoori +6 more
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KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex [PDF]
VirusesThe transcription and replication of the genome of influenza A virus (IAV) take place in the nucleus of infected cells, which is catalyzed by the viral ribonucleoprotein (vRNP) complex. The nuclear import of the vRNP complex and its component proteins is
Yu Chang +9 more
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]
Communications BiologyNucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse +11 more
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