Viruses, 2021 The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly
Qi Shen +4 more
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Nuclear Import of Yeast Proteasomes [PDF]
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
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HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome [PDF]
Retrovirology, 2009 Background Nuclear import of the HIV-1 reverse transcription complex (RTC) is critical for infection of non dividing cells, and importin 7 (imp7) has been implicated in this process.
Leyens Lada +5 more
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Direct visualization of HIV-1 core nuclear import and its interplay with the nuclear pore [PDF]
EMBO ReportsDirect visualization of HIV-1 nuclear import through the nuclear pore complex (NPC) presents a technical challenge due to the rarity of this process.
Zhen Hou +6 more
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Inhibition of nuclear import suppresses androgen receptor action and overcomes resistance in prostate cancer [PDF]
BMC CancerBackground Androgen deprivation and androgen receptor (AR) antagonists are essential treatments for prostate cancers in the clinic. However, after an initially effective response, most tumors become resistant to androgen deprivation therapies. Resistance
Xuan Wang +4 more
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Structural and functional characterisation of ATF2 nuclear import reveals paralogue-selective importin-α recognition and a non-canonical NLS formed in trans [PDF]
Life Science AllianceATF2 enters the nucleus via importin-α/β1 using two basic clusters that bind major and minor sites of importin-α1. Structural and cell data reveal redundancy, CRM1 export, and c-Jun–assisted co-import. Activating transcription factor 2 (ATF2) is a member
Seyed Mohammad Ghafoori +6 more
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KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex [PDF]
VirusesThe transcription and replication of the genome of influenza A virus (IAV) take place in the nucleus of infected cells, which is catalyzed by the viral ribonucleoprotein (vRNP) complex. The nuclear import of the vRNP complex and its component proteins is
Yu Chang +9 more
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame [PDF]
Viruses, 2013 Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus.
Wei Wu, Shelly Au, Nelly Panté
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Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]
Communications BiologyNucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse +11 more
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