Types of nuclear localization signals and mechanisms of protein import into the nucleus [PDF]
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Multiple types of nuclear localization signals in Entamoeba histolytica [PDF]
Biochemistry and Biophysics ReportsEntamoeba histolytica is a protozoan parasite that belongs to the Amoebozoa supergroup whose study related to the nucleocytoplasmic transport of proteins through the nucleus is poorly studied.
Israel Canela-Pérez +4 more
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Identification of Nuclear Localization Signals in the ORF2 Protein of Porcine Circovirus Type 3 [PDF]
Viruses, 2019 Porcine circovirus type 3 (PCV3) contains two major open reading frames (ORFs) and the ORF2 gene encodes the major structural capsid protein. In this study, nuclear localization of ORF2 was demonstrated by fluorescence observation and subcellular ...
Chunxiao Mou +3 more
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Finding nuclear localization signals [PDF]
EMBO Reports, 2000 A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential NLSs. This final set matched in 43%
Murat Cokol, Burkhard Rost
exaly +4 more sources
Comprehensive analysis of the dynamic structure of nuclear localization signals [PDF]
Biochemistry and Biophysics Reports, 2015 Most transcription and epigenetic factors in eukaryotic cells have nuclear localization signals (NLSs) and are transported to the nucleus by nuclear transport proteins. Understanding the features of NLSs and the mechanisms of nuclear transport might help understand gene expression regulation, somatic cell reprogramming, thus leading to the treatment of
Hiroki Kaneko
exaly +4 more sources
Nuclear Delivery of Nanoparticle-Based Drug Delivery Systems by Nuclear Localization Signals [PDF]
Cells, 2023 Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies and diagnostic tools. This field focuses on the development of more sophisticated and precise nanoparticles (NPs) for targeted drug delivery, imaging, and sensing ...
Yuhan Nie, Guo Fu, Yuxin Leng
doaj +2 more sources
Two nuclear localization signals regulate intracellular localization of the duck enteritis virus UL13 protein [PDF]
Poultry Science, 2021 Duck enteritis virus (DEV) multifunctional tegument protein UL13 is predicted to be a conserved herpesvirus protein kinase; however, little is known about its subcellular localization signal.
Linjiang Yang +23 more
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Nuclear Localization Signals for Optimization of Genetically Encoded Tools in Neurons [PDF]
Frontiers in Cell and Developmental Biology, 2022 Nuclear transport in neurons differs from that in non-neuronal cells. Here we developed a non-opsin optogenetic tool (OT) for the nuclear export of a protein of interest induced by near-infrared (NIR) light.
Maksim M. Karasev +4 more
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Data from comprehensive analysis of nuclear localization signals [PDF]
Data in Brief, 2016 This article describes data related to a research article titled “Comprehensive analysis of the dynamic structure of nuclear localization signals” by Yamagishi et al. [1]. In this article, we provide the data covering wider range of the mammalian NLSs in
Ryosuke Yamagishi, Hiroki Kaneko
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Nonclassical nuclear localization signals mediate nuclear import of CIRBP [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance We uncovered a molecular mechanism by which multiple importins regulate nuclear import, phase separation, and stress granule recruitment of an RNA-binding protein. Our work permitted the identification of two types of nuclear localization signal (NLS) in cold-inducible RNA-binding protein (CIRBP).
Benjamin Bourgeois +11 more
openaire +4 more sources