Results 31 to 40 of about 226,269 (286)

Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals [PDF]

Journal of Biological Chemistry, 2004
Many important regulatory proteins, including cell cycle regulators and transcription factors, contain a phosphorylation site within or adjacent to a classic nuclear localization signal (NLS) sequence. Previous studies show that the nuclear localization of these cargoes can be regulated by phosphorylation at these sites.
Michelle T, Harreman, Trisha M, Kline, Heidi G, Milford, M Beth, Harben, Alec E, Hodel, Anita H, Corbett   +5 more
openaire   +2 more sources

Identification of a novel nuclear localization signal in Sam68 [PDF]

FEBS Letters, 1997
Sam68, a nuclear RNA binding protein, binds to Src and is phosphorylated at tyrosine residues in an M‐phase specific manner. Here we identified a stretch of 24 amino acid residues in the COOH‐terminal portion of Sam68 which function as a nuclear localization signal. This signal sequence bears no apparent homology to any other known nuclear localization
Ishidate, Takao, Yoshihara, Satoshi, Kawasaki, Yoshihiro, Roy, Badal Chandra, Toyoshima, Kumao, Akiyama, Tetsu   +5 more
openaire   +2 more sources

A nuclear localization signal binding protein in the nucleolus. [PDF]

The Journal of cell biology, 1990
We used functional wild-type and mutant synthetic nuclear localization signal peptides of SV-40 T antigen cross-linked to human serum albumin (peptide conjugates) to assay their binding to proteins of rat liver nuclei on Western blots. Proteins of 140 and 55 kD (p140 and p55) were exclusively recognized by wild-type peptide conjugates.
U T, Meier, G, Blobel
openaire   +2 more sources

Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped. [PDF]

PLoS ONE, 2011
Drosophila melanogaster wing development has been shown to rely on the activity of a complex of two proteins, Scalloped (Sd) and Vestigial (Vg). Within this complex, Sd is known to provide DNA binding though its TEA/ATTS domain, while Vg modulates this ...
Adam C Magico, John B Bell
doaj   +1 more source

Identification and functional dissection of localization signals within ataxin-3

Neurobiology of Disease, 2009
Spinocerebellar ataxia type 3 (SCA3) or Machado–Joseph disease (MJD) belongs to a group of autosomal dominant neurodegenerative diseases, which are caused by the expansion of a polyglutamine repeat in the affected protein, in this case ataxin-3. Ataxin-3
Paul Michel Aloyse Antony, Simone Mäntele, Phillip Mollenkopf, Jana Boy, Ralph H. Kehlenbach, Olaf Riess, Thorsten Schmidt   +6 more
doaj   +1 more source

Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Computational and Structural Biotechnology Journal, 2022
Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now.
Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa   +10 more
doaj   +1 more source

Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. [PDF]

PLoS ONE, 2013
The nucleoprotein (NP) of influenza A virus is transported into the nucleus via the classical importin α/β pathway, and proceeds via nuclear localization signals (NLSs) recognized by importin α molecules.
Yutaka Sasaki, Kyoji Hagiwara, Michinori Kakisaka, Kazunori Yamada, Tomoyuki Murakami, Yoko Aida   +5 more
doaj   +1 more source

Identification of cryptic nuclear localization signals in the prion protein

Neurobiology of Disease, 2003
Abnormal transport of C-terminally truncated prion protein (PrP) to the nucleus has been reported in cell models of familial prion disorders associated with a stop codon mutation at residues 145 or 160 of the PrP.
Yaping Gu, Joerg Hinnerwisch, Rebecca Fredricks, Sudheera Kalepu, Ravi Shankar Mishra, Neena Singh   +5 more
doaj   +1 more source

Conserved motifs in nuclear genes encoding predicted mitochondrial proteins in Trypanosoma cruzi.

PLoS ONE, 2019
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, exhibits peculiar biological features. Among them, the presence of a unique mitochondrion is remarkable. Even though the mitochondrial DNA constitutes up to 25% of total cellular DNA,
Lorena Becco, Pablo Smircich, Beatriz Garat   +2 more
doaj   +1 more source

Nuclear export and import of human hepatitis B virus capsid protein and particles. [PDF]

PLoS Pathogens, 2010
It remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core protein (HBc) and particles. To address this fundamental issue, we have identified four distinct HBc localization signals in the arginine rich domain (ARD) of
Hung-Cheng Li, Er-Yi Huang, Pei-Yi Su, Szu-Yao Wu, Ching-Chun Yang, Young-Sun Lin, Wen-Chang Chang, Chiaho Shih   +7 more
doaj   +1 more source