Results 51 to 60 of about 226,269 (286)

Identification and functional analysis of NOL7 nuclear and nucleolar localization signals

BMC Cell Biology, 2010
Background NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased mRNA and protein expression ...
Lingen Mark W, Doçi Colleen L, Zhou Guolin   +2 more
doaj   +1 more source

Fusarium graminearum Effector FgNls1 Targets Plant Nuclei to Induce Wheat Head Blight

Molecular Plant-Microbe Interactions, 2023
Fusarium head blight (FHB) caused by Fusarium graminearum is one of the most devastating diseases of wheat and barley worldwide. Effectors suppress host immunity and promote disease development. The genome of F. graminearum contains hundreds of effectors
Guixia Hao, Todd A. Naumann, Hui Chen, Guihua Bai, Susan McCormick, Hye-Seon Kim, Bin Tian, Harold N. Trick, Michael J. Naldrett, Robert Proctor   +9 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.

PLoS ONE, 2015
The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha, Progga Sen, Sarita Raghunayakula, Xiang-Dong Zhang   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RETRACTED: Regions of Bovine Adenovirus-3 Protein VII Involved in Interactions with Viral and Cellular Proteins

Viruses
The L 1 region of bovine adenovirus (BAdV)-3 encodes a multifunctional protein named protein VII. Anti-protein VII sera detected a protein of 26 kDa in transfected or BAdV-3-infected cells, which localizes to nucleus and nucleolus of infected/transfected
Shermila Kulanayake, Faryal Dar, Suresh K. Tikoo   +2 more
doaj   +1 more source

Subcellular localization of class II HDAs in Arabidopsis thaliana: nucleocytoplasmic shuttling of HDA15 is driven by light.

PLoS ONE, 2012
Class II histone deacetylases in humans and other model organisms undergo nucleocytoplasmic shuttling. This unique functional regulatory mechanism has been well elucidated in eukaryotic organisms except in plant systems.
Malona V Alinsug, Fang Fang Chen, Ming Luo, Ready Tai, Liwen Jiang, Keqiang Wu   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mechanical interaction between actin cytoskeleton and nucleus regulates intracellular YAP localization in osteogenic differentiation in human mesenchymal stem cells.

Nihon Kikai Gakkai ronbunshu, 2020
Mechanotransduction, in which mechanical forces and deformations are converted into biochemical signals to change gene expression, is critical for directing the differentiation of mesenchymal stem cells.
Masashi YAMAZAKI, Hiromichi FUJIE, Hiromi MIYOSHI   +2 more
doaj   +1 more source

Control of the nuclear localization of Extradenticle by competing nuclear import and export signals [PDF]

Genes & Development, 1999
The Drosophila PBC protein Extradenticle (Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in the presence of Hth. Here we present evidence that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES ...
M, Abu-Shaar, H D, Ryoo, R S, Mann
openaire   +2 more sources