Results 71 to 80 of about 226,269 (286)

Serum-Regulated Nuclear Localization Is Signal Specific [PDF]

Molecular Endocrinology, 1991
The activity of nuclear factors can be regulated by blocking their ability to enter the nucleus, but how the cell achieves this is not yet understood. We demonstrate herein the serum-responsive nuclear localization of adenovirus E1a protein and show that this serum dependence is a property of the nuclear localization signal itself.
openaire   +2 more sources

Regulation of Phytochrome B Nuclear Localization through Light-Dependent Unmasking of Nuclear-Localization Signals [PDF]

Current Biology, 2005
Phytochromes are red and far-red photoreceptors that regulate plant growth and development in response to environmental light cues. Phytochromes exist in two photo-interconvertible conformational states: an inactive Pr form and an active Pfr form. The alteration of phytochromes' subcellular location functions as a major regulatory mechanism of their ...
Chen, M, Tao, Y, Lim, J, Shaw, A, Chory, J   +4 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Identification of Nuclear Localization Sequence (NLS) Sites in R2R3-MYB Transcription Factor Involved in Anther Development

Cells
The R2R3-MYB family of transcription factors (TFs) plays a crucial role in cell specification and secondary metabolism regulation during plant development. In Arabidopsis, MS188, a typical R2R3-MYB protein, is essential for tapetal development and pollen
Si-Da Zhou, Que Zhou, Yan-Dan Cui, Xiang Zhong, Xing Chen, Xue-Rong Lin, Zhong-Nan Yang, Jun Zhu   +7 more
doaj   +1 more source

In silico analyses of dystrophin Dp40 cellular distribution, nuclear export signals and structure modeling

Data in Brief, 2015
Dystrophin Dp40 is the shortest protein encoded by the DMD (Duchenne muscular dystrophy) gene. This protein is unique since it lacks the C-terminal end of dystrophins. In this data article, we describe the subcellular localization, nuclear export signals
Alejandro Martínez-Herrera, Jorge Aragón, Rosa Ma. Bermúdez-Cruz, Ma. Luisa Bazán, Gabriela Soid-Raggi, Víctor Ceja, Andrea Santos Coy-Arechavaleta, Víctor Alemán, Francisco Depardón, Cecilia Montañez   +9 more
doaj   +1 more source

Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase. [PDF]

PLoS ONE, 2009
BACKGROUND:The transcription factor NFAT5 is a major inducer of osmoprotective genes and is required to maintain the proliferative capacity of cells exposed to hypertonic stress.
Anaïs Estrada-Gelonch, Jose Aramburu, Cristina López-Rodríguez   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast

G3: Genes, Genomes, Genetics, 2019
Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow ...
Ian S. Hsu, Bob Strome, Sergey Plotnikov, Alan M. Moses   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source