Regulation of Nuclear Localization during Signaling [PDF]
Journal of Biological Chemistry, 2001 Signaling pathways consist of a chain of biochemical events thatform the intracellular equivalent of a fire bucket brigade. An initialchange or chemical signal outside the cell is sensed at the cellsurface by a receptor, which then transduces the signal to thecytosol.
Martha Cyert
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Dissection of a Nuclear Localization Signal [PDF]
Journal of Biological Chemistry, 2001 The regulated process of protein import into the nucleus of a eukaryotic cell is mediated by specific nuclear localization signals (NLSs) that are recognized by protein import receptors. This study seeks to decipher the energetic details of NLS recognition by the receptor importin alpha through quantitative analysis of variant NLSs.
Mary R. Hodel +2 more
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NLSdb—major update for database of nuclear localization signals and nuclear export signals [PDF]
Nucleic Acids Research, 2017 NLSdb is a database collecting nuclear export signals (NES) and nuclear localization signals (NLS) along with experimentally annotated nuclear and non-nuclear proteins. NES and NLS are short sequence motifs related to protein transport out of and into the nucleus. The updated NLSdb now contains 2253 NLS and introduces 398 NES.
Michael Bernhofer +6 more
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Effect of Different Nuclear Localization Signals on the Subcellular Localization and Anti-HIV-1 Function of the MxB Protein [PDF]
Frontiers in Microbiology, 2021 Interferon exerts its antiviral activity by stimulating the expression of antiviral proteins. These interferon stimulate genes (ISGs) often target a group of viruses with unique molecular mechanisms.
Keli Chai +10 more
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Origin of the nuclear proteome on the basis of pre-existing nuclear localization signals in prokaryotic proteins [PDF]
Biology Direct, 2020 Background The origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one of the most important events in ...
Olga M. Lisitsyna +6 more
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Multiple Nuclear Localization Signals Mediate Nuclear Localization of the GATA Transcription Factor AreA [PDF]
Eukaryotic Cell, 2014 ABSTRACT The Aspergillus nidulans GATA transcription factor AreA activates transcription of nitrogen metabolic genes in response to nitrogen limitation and is known to accumulate in the nucleus during nitrogen starvation. Sequence analysis of AreA revealed multiple nuclear localization signals (NLSs), five
Hunter, Cameron C. +9 more
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PLoS ONE, 2011 The androgen receptor (AR) cofactor p44/WDR77, which regulates expression of a set of androgen target genes, is required for differentiation of prostate epithelium.
Zhongping Gu +3 more
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Localization of BRCA1 and a Splice Variant Identifies the Nuclear Localization Signal [PDF]
Molecular and Cellular Biology, 1997 Inherited mutations in BRCA1 confer susceptibility to breast and ovarian neoplasms. However, the function of BRCA1 and the role of BRCA1 in noninherited cancer remain unknown. Characterization of alternately spliced forms of BRCA1 may identify functional regions; thus, we constructed expression vectors of BRCA1 and a splice variant lacking exon 11 ...
Sanjay Kumar Daulat Thakur +10 more
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Editing the nuclear localization signals of
Plant Biotechnol JYang Gao +7 more
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