Structural and functional characterisation of ATF2 nuclear import reveals paralogue-selective importin-α recognition and a non-canonical NLS formed in trans [PDF]
Life Science AllianceATF2 enters the nucleus via importin-α/β1 using two basic clusters that bind major and minor sites of importin-α1. Structural and cell data reveal redundancy, CRM1 export, and c-Jun–assisted co-import. Activating transcription factor 2 (ATF2) is a member
Seyed Mohammad Ghafoori +6 more
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Nuclear import in viral infections
, 2004 The separation of transcription in the nucleus and translation in the cytoplasm requires nucleo-cytoplasmic exchange of proteins and RNAs. Viruses have evolved strategies to capitalize on the nucleo-cytoplasmic trafficking machinery of the cell. Here, we
Fornerod, M, Greber, U F
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KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex [PDF]
VirusesThe transcription and replication of the genome of influenza A virus (IAV) take place in the nucleus of infected cells, which is catalyzed by the viral ribonucleoprotein (vRNP) complex. The nuclear import of the vRNP complex and its component proteins is
Yu Chang +9 more
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability. [PDF]
Nat MicrobiolLentiviruses, such as HIV-1, infect non-dividing cells by traversing the nuclear pore complex (NPC); however, the detailed molecular processes remain unclear.
Hou Z +10 more
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Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]
Communications BiologyNucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse +11 more
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A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import [PDF]
EMBO Molecular MedicineHIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-
Aude Boulay +13 more
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Nuclear import of histones [PDF]
Biochemical Society Transactions, 2020 The transport of histones from the cytoplasm to the nucleus of the cell, through the nuclear membrane, is a cellular process that regulates the supply of new histones in the nucleus and is key for DNA replication and transcription. Nuclear import of histones is mediated by proteins of the karyopherin family of nuclear transport receptors.
Natalia Elisa Bernardes, Yuh Min Chook
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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Effect of VIRP1 Protein on Nuclear Import of Citrus Exocortis Viroid (CEVd)
Biomolecules, 2021 Before replicating, Pospiviroidae viroids must move into the plant nucleus. However, the mechanisms of viroid nuclear import are not entirely understood.
Hyesu Seo, Kyunghee Kim, Woong June Park
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