Results 11 to 20 of about 270,346 (298)
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import [PDF]
EMBO Molecular MedicineHIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-
Aude Boulay +13 more
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Nuclear import of histones [PDF]
Biochemical Society Transactions, 2020 The transport of histones from the cytoplasm to the nucleus of the cell, through the nuclear membrane, is a cellular process that regulates the supply of new histones in the nucleus and is key for DNA replication and transcription. Nuclear import of histones is mediated by proteins of the karyopherin family of nuclear transport receptors.
Natalia Elisa Bernardes, Yuh Min Chook
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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Effect of VIRP1 Protein on Nuclear Import of Citrus Exocortis Viroid (CEVd)
Biomolecules, 2021 Before replicating, Pospiviroidae viroids must move into the plant nucleus. However, the mechanisms of viroid nuclear import are not entirely understood.
Hyesu Seo, Kyunghee Kim, Woong June Park
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Retrovirology, 2020 Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import
Linlin Xie +11 more
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CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import
Microbiology Spectrum, 2021 To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved.
Julie Janssens +10 more
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Nuclear Import of Adeno-Associated Viruses Imaged by High-Speed Single-Molecule Microscopy
Viruses, 2021 Understanding the detailed nuclear import kinetics of adeno-associated virus (AAV) through the nuclear pore complex (NPC) is essential for the application of AAV capsids as a nuclear delivery instrument as well as a target for drug development.
Samuel L. Junod +2 more
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Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
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PP2A Regulates HDAC4 Nuclear Import [PDF]
Molecular Biology of the Cell, 2008 Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio +9 more
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Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. [PDF]
PLoS Pathogens, 2017 The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated ...
Ryan C Burdick +6 more
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