Results 11 to 20 of about 68,550 (256)

A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import [PDF]

EMBO Molecular Medicine
HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-
Aude Boulay, Emmanuel Quevarec, Isabelle Malet, Giuseppe Nicastro, Célia Chamontin, Suzon Perrin, Corinne Henriquet, Martine Pugnière, Valérie Courgnaud, Mickaël Blaise, Anne-Geneviève Marcelin, Ian A Taylor, Laurent Chaloin, Nathalie J Arhel   +13 more
doaj   +2 more sources

Nuclear import of histones [PDF]

Biochemical Society Transactions, 2020
The transport of histones from the cytoplasm to the nucleus of the cell, through the nuclear membrane, is a cellular process that regulates the supply of new histones in the nucleus and is key for DNA replication and transcription. Nuclear import of histones is mediated by proteins of the karyopherin family of nuclear transport receptors.
Natalia Elisa Bernardes, Yuh Min Chook
openaire   +2 more sources

Non-transport roles of nuclear import receptors: In need of the right balance

Frontiers in Cell and Developmental Biology, 2022
Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia, Ludovica Altieri, Ludovica Altieri, Patrizia Lavia, Patrizia Lavia   +4 more
doaj   +1 more source

Effect of VIRP1 Protein on Nuclear Import of Citrus Exocortis Viroid (CEVd)

Biomolecules, 2021
Before replicating, Pospiviroidae viroids must move into the plant nucleus. However, the mechanisms of viroid nuclear import are not entirely understood.
Hyesu Seo, Kyunghee Kim, Woong June Park
doaj   +1 more source

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

Retrovirology, 2020
Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import
Linlin Xie, Lang Chen, Chaojie Zhong, Ting Yu, Zhao Ju, Meirong Wang, Hairong Xiong, Yan Zeng, Jianhua Wang, Haitao Hu, Wei Hou, Yong Feng   +11 more
doaj   +1 more source

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

Microbiology Spectrum, 2021
To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved.
Julie Janssens, Jolien Blokken, Yulia Lampi, Flore De Wit, Irena Zurnic Bonisch, Ivan Nombela, Paulien Van de Velde, Barbara Van Remoortel, Rik Gijsbers, Frauke Christ, Zeger Debyser   +10 more
doaj   +1 more source

Nuclear Import of Adeno-Associated Viruses Imaged by High-Speed Single-Molecule Microscopy

Viruses, 2021
Understanding the detailed nuclear import kinetics of adeno-associated virus (AAV) through the nuclear pore complex (NPC) is essential for the application of AAV capsids as a nuclear delivery instrument as well as a target for drug development.
Samuel L. Junod, Jason Saredy, Weidong Yang   +2 more
doaj   +1 more source

Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5)

Biomolecules, 2023
The ribosome is assembled in a complex process mainly taking place in the nucleus. Consequently, newly synthesized ribosomal proteins have to travel from the cytoplasm into the nucleus, where they are incorporated into nascent ribosomal subunits. In this
Andreas Steiner, Sébastien Favre, Maximilian Mack, Annika Hausharter, Benjamin Pillet, Jutta Hafner, Valentin Mitterer, Dieter Kressler, Brigitte Pertschy, Ingrid Zierler   +9 more
doaj   +1 more source

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. [PDF]

PLoS Pathogens, 2018
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP).
Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen   +20 more
doaj   +1 more source

Nuclear protein import [PDF]

Current Opinion in Cell Biology, 1997
The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
openaire   +3 more sources