Results 21 to 30 of about 270,346 (298)

Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5)

Biomolecules, 2023
The ribosome is assembled in a complex process mainly taking place in the nucleus. Consequently, newly synthesized ribosomal proteins have to travel from the cytoplasm into the nucleus, where they are incorporated into nascent ribosomal subunits. In this
Andreas Steiner, Sébastien Favre, Maximilian Mack, Annika Hausharter, Benjamin Pillet, Jutta Hafner, Valentin Mitterer, Dieter Kressler, Brigitte Pertschy, Ingrid Zierler   +9 more
doaj   +1 more source

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. [PDF]

PLoS Pathogens, 2018
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP).
Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen   +20 more
doaj   +1 more source

Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]

, 2008
Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike, Straube, Anne, Steinberg, Gero   +2 more
core   +1 more source

Nuclear protein import [PDF]

Current Opinion in Cell Biology, 1997
The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
openaire   +3 more sources

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels [PDF]

, 2001
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these ...
Benne R., Beverley S.M., Brun R., Carruthers V.B., Czichos J., Feagin J.E., Folsch H., Hahne K., Hauser R., Hausler T., Hirumi H., Kwast K.E., LeBowitz J.H., Matthews K.R., Osinga K.A., Overath P., Priest J.W., Roditi I., Sherwin T., Smagula C., Sogin M.L., Stuart K., Tasker M., Torri A.F., Tschudi C., Ullu E., Vassella E., Wirtz E., Woods A., Ziegelbauer K.   +29 more
core   +1 more source

Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

Retrovirology, 2011
Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the
Sheehy Noreen, Yeo Geok P, Jarboui Mohamed, Tsuji Takahiro, Gu Lili, Hall William W, Gautier Virginie W   +6 more
doaj   +1 more source

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]

, 2010
In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza, Auer, Manfred, Bednenko, Janna, Gerace, Larry, Gstach, Hubert, Hintersteiner, Martin, Knox, Andrew J. S., Meisner, Nicole-Claudia, Schmied, Mario, Seifert, Jan-Marcus, Singer, Eric L.   +10 more
core   +1 more source

Neutrino Interactions Importance to Nuclear Physics [PDF]

AIP Conference Proceedings, 2009
To appear in the proceedings of 6th International Workshop on Neutrino-Nucleus Interactions in the Few-GeV Region (NuInt09), Sitges, Spain, 18 - 22 May ...
J. E. Amaro, C. Maieron, M. Valverde, J. Nieves, M. B. Barbaro, J. A. Caballero, T. W. Donnelly, J. M. Udias, Federico Sanchez, M. Sorel, Luis Alvarez-Ruso   +10 more
openaire   +5 more sources

tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes.

PLoS Biology, 2006
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Lyubov Zaitseva, Richard Myers, Ariberto Fassati   +2 more
doaj   +1 more source

UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. [PDF]

PLoS ONE, 2013
Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase.
Zhengke Li, Phillip R Musich, Brian M Cartwright, Hui Wang, Yue Zou   +4 more
doaj   +1 more source