Results 1 to 10 of about 292,166 (318)

Sequence specificity of an essential nuclear localization sequence in Mcm3. [PDF]

PLoS Genet
Abstract Proteins with nuclear localization sequences (NLSs) are directed into the cell nucleus through interactions between the NLS and importin proteins. NLSs are generally short motifs rich in basic amino acids; however, identifying NLSs can be challenging due to the lack of a universally conserved sequence.
Wang Z, Zhang YJ, Zhang QY, Bilsborrow K, Leslie M, Suhandynata RT, Zhou H.   +6 more
europepmc   +12 more sources

Unraveling the Nuclear Localization Sequence of MoHTR2, the Nuclear Effector of Magnaporthe oryzae. [PDF]

Plant Pathol J
Plant pathogenic fungi modulate host immunity by secreting nuclear effectors that interact with host nucleic acids and proteins within the host nucleus. Nuclear effectors are widely known to possess a nuclear localization sequence (NLS) that allows them to enter the host nucleus through either the classical importin α-mediated or non-classical pathways.
Choi J, Lim YJ, Lee YH.
europepmc   +6 more sources

Bioinformatics and Functional Analysis of a New Nuclear Localization Sequence of the Influenza A Virus Nucleoprotein. [PDF]

Cells, 2022
Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently ...
Nguyen NLT, Panté N.
europepmc   +5 more sources

A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin [PDF]

FEBS Letters, 2005
Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence 58KKRRRRARK66, when tagged to either enhanced green fluorescent protein (EGFP) or to enhanced cyan fluorescent protein‐CapG (ECFPCapG), is able to target these proteins to the ...
De Ganck, Ariane, Hubert, Thomas, Van Impe, Katrien, Geelen, Danny, Vandekerckhove, Joël, De Corte, Veerle, Gettemans, Jan   +6 more
exaly   +6 more sources

Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3. [PDF]

Int J Mol Sci, 2022
The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) comprising residues Pro320 to Asp328, to allow for nuclear translocation.
Rizzuti B, Iovanna JL, Neira JL.
europepmc   +8 more sources

Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2 [PDF]

Cell, 2006
Karyopherinbeta (Kapbeta) proteins bind nuclear localization and export signals (NLSs and NESs) to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its nucleotide cycle. Diversity and complexity of signals recognized by Kap betas have prevented prediction of new Kap beta substrates.
Lee, Brittany J., Cansizoglu, Ahmet E., Süel, Katherine E., Louis, Thomas H., Zhang, Zichao, Chook, Yuh Min   +5 more
exaly   +5 more sources

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

Engineering, 2015
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N ...
Wei Zhang, Xiaoli Yang, Jingjing Song, Xin Zheng, Jianbo Chen, Panpan Ma, Bangzhi Zhang, Rui Wang   +7 more
exaly   +5 more sources

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. [PDF]

Cells, 2022
Lampart A, Sluzalska KD, Czyrek A, Szerszen A, Otlewski J, Wiedlocha A, Zakrzewska M.   +6 more
europepmc   +5 more sources

Chitosan Nanoparticles for Nuclear Targeting: The Effect of Nanoparticle Size and Nuclear Localization Sequence Density

Molecular Pharmaceutics, 2015
Many recently discovered therapeutic proteins exert their main function in the nucleus, thus requiring both efficient uptake and correct intracellular targeting. Chitosan nanoparticles (NPs) have attracted interest as protein delivery vehicles due to their biocompatibility and ability to escape the endosomes offering high potential for nuclear delivery.
Salma N, Tammam, Hassan M E, Azzazy, Hans G, Breitinger, Alf, Lamprecht   +3 more
exaly   +5 more sources

Analysis of conserved binding proteins for nuclear localization sequences [PDF]

Journal of Cell Science, 1993
ABSTRACT Correct targeting of nuclear proteins is mediated by nuclear localization sequences (NLS) which permit specific binding to the nucleus and subsequent translocation across the nuclear envelope via the nuclear pore complex. It is proposed that nuclear import is facilitated by NLS-receptors which reside in the cytoplasm and at the ...
Ursula Stochaj, Mark A. Bossie, Karen van Zee, Anne M. Whalen, Pamela A. Silver   +4 more
openalex   +3 more sources