Localization of Daucus carota NMCP1 to the nuclear periphery: the role of the N-terminal region and an NLS-linked sequence motif, RYNLRR, in the tail domain [PDF]
Frontiers in Plant Science, 2014 Recent ultrastructural studies revealed that a structure similar to the vertebrate nuclear lamina exists in the nuclei of higher plants. However, plant genomes lack genes for lamins and intermediate-type filament proteins, and this suggests that plant ...
Yuta Kimura +3 more
openalex +3 more sources
Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains. [PDF]
Front Plant Sci, 2018 Proteins of the Poly(ADP-Ribose) Polymerase (PARP) family modify target proteins by covalent attachment of ADP-ribose moieties onto amino acid side chains.
Chen C +3 more
europepmc +4 more sources
Cellular Import Mediated by Nuclear Localization Signal Peptide Sequences [PDF]
Chemistry & Biology, 2002 The cellular delivery of therapeutic agents and their localization within cells is currently a great challenge in medicinal chemistry. A few cationic peptides have shown a strong propensity to cross the cytoplasmic membrane and enter cells. Nuclear localization signal (NLS) sequences are a class of highly cationic peptides that may be exploited for ...
Angela D. Ragin +2 more
openalex +3 more sources
Nuclear Targeting of the Maize R Protein Requires Two Nuclear Localization Sequences [PDF]
Plant Physiology, 1993 Previous genetic and structural evidence indicates that the maize R gene encodes a nuclear transcriptional activating factor. In-frame carboxyl- and amino-terminal fusions of the R gene to the reporter gene encoding beta-glucuronidase (GUS) were sufficient to direct GUS to the nucleus of the transiently transformed onion (Allium cepa) epidermal cells ...
Mark W. Shieh +2 more
openalex +4 more sources
Sequence Determinants for hnRNP I Protein Nuclear Localization
Experimental Cell Research, 1997 hnRNP I, also referred to as polypyrimidine tract binding protein, is one of the proteins associated with nascent pre-mRNA in the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. As for all karyophilic proteins, the nuclear import of hnRNP proteins requires specific sequence determinants that in many instances differ from the canonical import
Romanelli M. G. +4 more
openaire +4 more sources
Multiple Nuclear Localization Sequences Allow Modulation of 5‐Lipoxygenase Nuclear Import [PDF]
Traffic, 2004 The nuclear import of proteins typically requires the presence of a nuclear localization sequence (NLS). Some proteins have more than one NLS, but the significance of having multiple NLSs is unclear. The enzyme 5‐lipoxygenase (5‐LO) has three NLSs that, unlike the tight cluster of basic residues of the classical SV40 large T antigen NLS, contain ...
Ming Luo +3 more
openalex +5 more sources
Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]
PLoS ONE, 2012 Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Johannes Matschke +5 more
doaj +3 more sources
Journal of Tissue Engineering, 2015 The N-terminus of parathyroid hormone–related protein regulates bone marrow stromal cell differentiation. We hypothesized that the nuclear localization sequence and C-terminus are involved.
Blake E Hildreth +2 more
exaly +2 more sources
Identification of a novel nuclear localization signal sequence in Chlamydia trachomatis-secreted hypothetical protein CT311. [PDF]
PLoS ONE, 2013 We previously reported that Chlamydia trachomatis hypothetical protein CT311 was secreted out of chlamydial inclusion and into host cell cytosol. We now found that CT311 further entered host cell nucleus at the late stage of infection and continued to ...
Lei Lei +3 more
doaj +2 more sources
Yeast proteins that recognize nuclear localization sequences. [PDF]
The Journal of cell biology, 1989 A variety of peptides can mediate the localization of proteins to the nucleus. We have identified yeast proteins of 70 and 59 kD that bind to nuclear localization peptides of SV-40 T antigen, Xenopus nucleoplasmin, and the yeast proteins Ga14 and histone H2B.
Pamela A. Silver +2 more
openalex +3 more sources