Identification of the sequence responsible for the nuclear localization of human Cdc6
FEBS Letters, 1999 The Cdc6 is the essential protein for the initiation of DNA replication. Cdc6 is localized in the G1 nucleus, and abnormal nuclear localization of this protein induces irregular initiation of DNA replication. We identified here that amino acids K57 and R58 in the human Cdc6 protein play an important role in the nuclear localization of the protein.
Takei, Yoshinori +2 more
openaire +3 more sources
Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequence [PDF]
Genes to Cells, 1997 Background:The proteins of the Mcm2‐7 family are required for the initiation of DNA replication. In Saccharomyces cerevisiae the nuclear envelope does not break down during the mitotic phase of the cell cycle. Large nuclear proteins, such as the Mcm proteins, which accumulate in the nucleus during specific portions of the cell cycle, must have ...
Young, Michael R. +4 more
openaire +4 more sources
A novel transfecting peptide comprising a tetrameric nuclear localization sequence
Journal of Molecular Medicine, 2003 The transport of exogenous DNA into the nucleus of eukaryotic cells is a prerequisite for successful gene delivery. To favor nuclear transport we synthesized a tetramer of the nuclear localization signal (NLS) of the SV40 large T-antigen as a novel nonviral gene delivery vector.
Wolfgang, Ritter +6 more
openaire +3 more sources
A Functional Nuclear Localization Sequence in the C-terminal Domain of SHP-1 [PDF]
Journal of Biological Chemistry, 2001 The Src homology 2 domain-containing protein tyrosine phosphatases SHP-1 and SHP-2 play an important role in many intracellular signaling pathways. Both SHP-1 and SHP-2 have been shown to interact with a diverse range of cytosolic and membrane-bound signaling proteins. Generally, SHP-1 and SHP-2 perform opposing roles in signaling processes; SHP-1 acts
Graham Craggs, Stuart Kellie
openalex +6 more sources
Identification of sequence determinants of human nuclear dUTPase isoform localization
Experimental Cell Research, 2003 dUTP nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is the central regulator of cellular dUTP pools. Nuclear (DUT-N) and mitochondrial (DUT-M) isoforms of the protein have been identified in humans and arise from the same gene by the alternative use of 5' exons.
Tinkelenberg, Beverly A +3 more
openaire +3 more sources
A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3
Virology, 2012 The capsid proteins of some RNA viruses can translocate to the nucleus and interfere with cellular phenotypes. In this study we found that the VP1 capsid protein of coxsackievirus B3 (CVB3) was dominantly localized in the nucleus of the cells transfected
Tianying Wang +2 more
exaly +2 more sources
Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30). [PDF]
Parasitol Res, 2022 Bingxiang W +6 more
europepmc +3 more sources
A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin. [PDF]
Biomolecules, 2020 Neira JL +6 more
europepmc +3 more sources
Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro. [PDF]
J Nanobiotechnology, 2019 Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use as a drug.
Malik S, Bahal R.
europepmc +2 more sources
Platinum (II) complex-nuclear localization sequence peptide hybrid for overcoming platinum resistance in cancer therapy. [PDF]
ACS Biomater Sci Eng, 2018 Wlodarczyk MT +6 more
europepmc +3 more sources