The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered. [PDF]
Arch Biochem Biophys, 2019 Pantoja-Uceda D +5 more
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Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation. [PDF]
Biochemistry, 2018 McGurk L +4 more
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The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. [PDF]
Nat Commun, 2020 Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) shuttles between the nucleus and cytoplasm to regulate gene expression and RNA metabolism and its low complexity (LC) C-terminal domain facilitates liquid–liquid phase separation and amyloid ...
Sun Y +12 more
europepmc +2 more sources
A Balance Between Two Nuclear Localization Sequences and a Nuclear Export Sequence Governs Extradenticle Subcellular Localization [PDF]
Genetics, 2007 Abstract During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax (Hth ...
Katherine E, Stevens, Richard S, Mann
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Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability. [PDF]
PLoS ONE, 2013 G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates
Laura R Johnson +3 more
doaj +1 more source
Cells, 2023 Electroreception through ampullae of Lorenzini in the little skate, Leucoraja erinacea, involves functional coupling between voltage-activated calcium channels (CaV1.3, cacna1d) and calcium-activated big-conductance potassium (BK) channels (BK, kcnma1 ...
Abby L. Chen +4 more
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Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. [PDF]
PLoS ONE, 2011 Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle.
Allen C T Teng +6 more
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Specific Binding of Nuclear Localization Sequences to Plant Nuclei [PDF]
The Plant Cell, 1993 We have begun to dissect the import apparatus of higher plants by examining the specific association of nuclear localization sequences (NLSs) with purified plant nuclei. Peptides to the simian virus 40 (SV40) large T antigen NLS and a bipartite NLS of maize were allowed to associate with tobacco and maize nuclei.
G R, Hicks, N V, Raikhel
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The role of IFNγ nuclear localization sequence in intracellular function [PDF]
Journal of Cell Science, 2003 Intracellularly expressed interferon γ (IFNγ) has been reported to possess biological activity similar to that of IFNγ added to cells. This study addresses the mechanisms for such similar biological effects. Adenoviral vectors were used to express a non-secreted form of human IFNγ or a non-secreted mutant form in which a previously demonstrated nuclear
C M Iqbal, Ahmed +4 more
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Characterization of sequences in human TWIST required for nuclear localization [PDF]
BMC Cell Biology, 2009 Twist is a transcription factor that plays an important role in proliferation and tumorigenesis. Twist is a nuclear protein that regulates a variety of cellular functions controlled by protein-protein interactions and gene transcription events. The focus of this study was to characterize putative nuclear localization signals (NLSs) 37RKRR40 and ...
Singh, Shalini, Gramolini, Anthony O
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