Results 51 to 60 of about 292,166 (318)

Differences in the localization and morphology of chromosomes in the human nucleus [PDF]

, 1999
Using fluorescence in situ hybridization we show striking differences in nuclear position, chromosome morphology, and interactions with nuclear substructure for human chromosomes 18 and 19.
Perry, P, Wendy A. Bickmore, Boyle, S, Bridger, JM, Bickmore, W A, Jenny A. Croft, Bridger, J M, Paul Perry, Croft, J A, Shelagh Boyle, Croft, J, Bickmore, WA, Joanna M. Bridger, Peter Teague, Teague, P   +14 more
core   +1 more source

Enhancement of Polylysine-Mediated Transferrinfection by Nuclear Localization Sequences: Polylysine Does Not Function as a Nuclear Localization Sequence

Human Gene Therapy, 1999
Polylysine (pLy) has been used successfully as a DNA carrier in receptor-mediated gene transfer, enhancement of transfection having been proposed to be in part through efficient nuclear targeting stemming from the resemblance of pLy to the nuclear localization sequence (NLS) from simian virus SV40 large tumor antigen (T-ag).
Chan, Chee Kai, Jans, David A
openaire   +3 more sources

Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment [PDF]

, 2001
The microtubule-binding integral 63 kD cytoskeleton-linking membrane protein (CLIMP-63; former name, p63) of the rough endoplasmic reticulum (ER) is excluded from the nuclear envelope.
Klopfenstein, D. R., Viola Oorschot, Klumperman, J., Ariel Lustig, Richard A. Kammerer, Kammerer, Richard A., Hauri, H. P., Hans-Peter Hauri, Oorschot, Viola, Lustig, A., Klopfenstein, Dieter R., Kammerer, R. A., Lustig, Ariel, Hauri, Hans Peter, Judith Klumperman, Oorschot, V., Klumperman, Judith, Dieter R. Klopfenstein   +17 more
core   +1 more source

The Nuclear Localization of Glycogen Synthase Kinase 3β Is Required Its Putative PY-Nuclear Localization Sequences [PDF]

Molecules and Cells, 2012
Glycogen synthase kinase-3β(GSK-3β), which is a member of the serine/threonine kinase family, has been shown to be crucial for cellular survival, differentiation, and metabolism. Here, we present evidence that GSK-3β is associated with the karyopherin β2 (Kap β2) (102-kDa), which functions as a substrate for transportation into the nucleus. A potential
Sung Hwa, Shin, Eun Jeoung, Lee, Jaesun, Chun, Sunghee, Hyun, Youg Il, Kim, Sang Sun, Kang   +5 more
openaire   +2 more sources

Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences [PDF]

Journal of Biological Chemistry, 1997
The process of nuclear protein transport requires the interaction of several different proteins, either directly or indirectly with nuclear localization or targeting sequences (NLS). Recently, a number of karyopherins alpha, or NLS-binding proteins, have been identified.
S G, Nadler, D, Tritschler, O K, Haffar, J, Blake, A G, Bruce, J S, Cleaveland   +5 more
openaire   +2 more sources

Diffusion of Proteins Across the Nuclear Envelope of HeLa Cells

BioTechniques, 1998
We describe an experimental system to study nucleocytoplasmic diffusion of proteins in living HeLa cells. To localize proteins to the nucleus, substrates were created that contain a nuclear localization sequence fused to Aequorea victoria green ...
Shivani Chatterjee, Ursula Stochaj
doaj   +1 more source

Contribution of the Nuclear Localization Sequences of Influenza A Nucleoprotein to the Nuclear Import of the Influenza Genome in Infected Cells

Viruses, 2023
Replication of the RNA genome of influenza A virus occurs in the nucleus of infected cells. The influenza nucleoprotein (NP) associated with the viral RNA into ribonucleoprotein complexes (vRNPs) is involved in the nuclear import of the viral genome.
Nhan L. T. Nguyen, Wei Wu, Nelly Panté
doaj   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
core   +1 more source

Up‐regulation of nuclear protein import by nuclear localization signal sequences in living cells [PDF]

FEBS Letters, 1999
Using an in vivo assay system, nuclear import ability in individual cells was determined by examining the nuclear import rate. It was found that when a small (not excess) amount of SV40 T‐NLS peptides was co‐injected, the nuclear import rate of SV40 T‐NLS‐containing substrates apparently increased.
Tachibana, Taro, Hieda, Miki, Yoneda, Yoshihiro   +2 more
openaire   +2 more sources

The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking

Viruses, 2021
Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison, Cassandra T. David, Stephen M. Rawlinson, Gregory W. Moseley   +3 more
doaj   +1 more source