Results 71 to 80 of about 21,607 (213)

Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer

Acta Pharmaceutica Sinica B, 2023
Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many cancers. However, the lack of druggable inhibitors restricts its therapeutic proof of concept. In the present work, we optimized a natural importin-β1
Jia-Luo Huang, Xue-Long Yan, Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang, Sheng Yin   +12 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts

Virulence, 2018
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear ...
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu   +8 more
doaj   +1 more source

Importin-α4 and importin-α7 form complexes with XPA in cells.

, 2013
A. XPA was detected in the protein complexes of importin-α4 or importin-α7 by Western blotting. Immunoprecipitation of importin-α4 or importin-α7 also pulled down XPA in lysates from H1299 cells which were UV-C irradiated (20 J/m2) and allowed a ½ h ...
Hui Wang (30400), Phillip R. Musich (337656), Yue Zou (15851), Zhengke Li (337655), Brian M. Cartwright (431428)   +4 more
core   +1 more source

Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice

Frontiers in Neuroscience, 2022
Importin α3 (Gene: Kpna3, the ortholog of human Importin α4) is a member of the importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins and importin β1.
Yoshiatsu Aomine, Yoshiatsu Aomine, Koki Sakurai, Koki Sakurai, Tom Macpherson, Tom Macpherson, Takaaki Ozawa, Takaaki Ozawa, Yoichi Miyamoto, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida, Takatoshi Hikida   +12 more
doaj   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Biophysical characterization of interactions involving importin-alpha during nuclear import [PDF]

, 2001
Proteins containing the classical nuclear localization sequences (NLSs) are imported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha contains the NLS binding site, whereas importin-beta mediates the translocation through the ...
Jennings, I. G., Jenning, Ian G, Kobe, Bostjan, Howlett, Geoffrey, Jennings, Ian G., Fontes, M. R. M., Jans, D. A., Nice, Edouard C., Kobe, B., Howlett, G. J., Catimel, B., Howlett, Geoffrey J., Fontes, Marcos, Fontes, Marcos R. M., Teh, T., Catimel, Bruno, Jans, David A., Nice, E. C., Jans, David A, Teh, Trazel, Fontes, Marcos R. M. [UNESP], Nice, Edouard C   +21 more
core   +1 more source

Expression Analysis and Nuclear Import Study of Full-length Isoforms Importin α as 6x Histidin-tagged Fusion Protein on the Intracellular Localization of Recombinant HBV Core Protein

Indonesian Journal of Biotechnology, 2015
Isoform importin α molecules play a central role in the classical nuclear import pathway, that occurs throughthe nuclear pore complex (NPC) and typically requires a specific nuclear localization signal (NLS).
Aris Haryanto
doaj  

RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes

EMBO Journal, 2019
Homologous chromosome segregation during meiosis I (MI) in mammalian oocytes is carried out by the acentrosomal MI spindles. Whereas studies in human oocytes identified Ran GTPase as a crucial regulator of the MI spindle function, experiments in mouse ...
Dávid Drutovič, Xing Duan, Rong Li, P. Kalab, P. Solc   +4 more
semanticscholar   +1 more source