Results 71 to 80 of about 16,651 (218)
Binding parameters of h-importin-α1 and ΔIBB-h-importin-α1 by ITC.
, 2015 KD: dissociation constant,N: number of binding sites,ΔH: binding enthalpy,N.D. not detectable.Binding parameters of h-importin-α1 and ΔIBB-h-importin-α1 by ITC.
Yuko Tatsumi (690327) +7 more
core +1 more source
Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia
Movement Disorders, EarlyView.Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot +22 more
wiley +1 more source
Viruses Challenge Selectivity Barrier of Nuclear Pores
Viruses, 2013 Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
doaj +1 more source
New Plant Protection, EarlyView.This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu +4 more
wiley +1 more source
Crystallization of importin α, the nuclear-import receptor [PDF]
Acta Crystallographica Section D Biological Crystallography, 1999 Crystals of recombinant importin α, the nuclear-import receptor, have been obtained at two different pH conditions by vapour diffusion using sodium citrate as precipitant and dithiothreitol as an additive. At pH 4–5, the crystals have the symmetry of the trigonal space group P3121 or P3221 (a = b = 78.0, c = 255.8 Å, γ = 120°); at pH 6–7, the crystals ...
Teh, T, Tiganis, T, Kobe, B
openaire +5 more sources
, 2015 This work was supported by the Swedish Research Council Formas (to E.I.S.), the Carl Tryggers Foundation (to E.I.S. and N.I.L.), the Swedish Institute (to N.I.L.), and the Rural and Environmental Science and Analytical Services Division strategic ...
Savenkov, Eugene I. +5 more
core +1 more source
Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells
Scientific ReportsInterleukin-1α (IL-1α), a cytokine released by necrotic cells, causes sterile inflammation. On the other hand, IL-1α is present in the nucleus and also regulates the expression of many proteins.
Akiko Yamada +5 more
doaj +1 more source
Innate immunity shapes the persistent transmission of plant viruses by insect vectors
New Plant Protection, EarlyView.In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley +1 more source
, 2008 ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
Wenbo Lin +11 more
core
Importin beta validates human importin beta as a cell cycle negative regulator-1
, 2011 Cked nuclear membrane fusion, as shown by the lack of a solid nuclear rim stain by the green fluorescent membrane dye DHCC. The block to membrane fusion could be rescued by the addition of RanQ69L-GTP (+X-β +Ran).
Rene C Chan (63112) +2 more
core +1 more source