Results 81 to 90 of about 16,651 (218)

KPNB1 (karyopherin (importin) beta 1) [PDF]

, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is ...
Leaner, V, Lavia, P, Giubettini, M, van, der Watt P, Verrico, A, de, Turris V   +5 more
core   +1 more source

Biobanking efforts and new advances in male fertility preservation for rare and endangered species

Asian Journal of Andrology, 2015
Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Importin α3 regulates chronic pain pathways in peripheral sensory neurons

, 2020
How is neuropathic pain regulated in peripheral sensory neurons? Importins are key regulators of nucleocytoplasmic transport. In this study, we found that importin α3 (also known as karyopherin subunit alpha 4) can control pain responsiveness in ...
Alber, Stefanie, Rother, Franziska, Tzur, Yarden, Rishal, I., Rishal, Ida, Di Pizio, A., Fainzilber, M., Fainzilber, Mike, Bader, M., Dagan, S.Y., Okladnikov, N., Marvaldi, Letizia, Bader, Michael, Alber, S., Hartmann, E., Panayotis, N., Koppel, I., Panayotis, Nicolas, Di Pizio, Agostina, Koppel, Indrek, Rother, F., Tzur, Y., Hartmann, Enno, Gordon, Dalia, Song, D.A., Marvaldi, L., Terenzio, M., Gordon, D., Dagan, Shachar, Okladnikov, Nataliya, Song, Didi-Andreas, Terenzio, Marco   +31 more
core   +1 more source

Importin-11 keeps PTEN safe from harm [PDF]

, 2017
In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation.
Nick R. Leslie, Leslie, Nick R.; id_orcid   +1 more
core   +1 more source

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, EarlyView.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

Importin β interaction with GST-Cp183 fusion protein.

, 2016
(a) Confocal fluorescence microscopy of importin α-Alexa594 and importin β-Alexa488 with glutathione sepharose, coated with different GST fusion proteins. The protein coating the beads is indicated on the left.
Joseph Che-Yen Wang (195672), Christian Cazenave (370919), Adam Zlotnick (134075), Martin F. Jarrold (1310310), Elizabeth E. Pierson (2939595), David Z. Keifer (1310298), Mildred Delaleau (370916), Chao Chen (195669), Lara Gallucci (2939592), Michael Kann (119825)   +9 more
core   +1 more source

The role of Importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells

FEBS Open Bio, 2014
Members of the Importin-β family recognize nuclear localization signals (NLS) and nuclear export signals (NES). These proteins play important roles in various nucleocytoplasmic transport processes in cells. Here, we examined the expression patterns of 21
Percival Sangel, Masahiro Oka, Yoshihiro Yoneda   +2 more
doaj   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

Journal of Integrative Plant Biology, EarlyView.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang, Junyan Xie, Yiping Zou, Chunliang Yao, Hai Fan, Chenqi Shen, Wenyan Zhou, Jingran Qin, Xinke Zhang, Baoshan Wang, Jian Zhang, Guoliang Han   +11 more
wiley   +1 more source