Results 81 to 90 of about 21,607 (213)

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

A sejtmagi fehérje-import Importin-alfa2 faktorának citoplazmatikus funkciói = Cytoplasmic functions of Importin-alpha2, a factor of nuclear protein import [PDF]

, 2011
Az importin-alfa2D14 + / + importin-ßKetelRE34 Drosophila nőstényektől származó embriók letálisak. Jellemeztük a maternális interakciót. Főbb eredményeink: - embrió letalitás a szinciciális blasztoderma állapotban a metafázisban blokkolt osztódási orsó
Kiss, István, Szlanka, Tamás
core   +1 more source

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr

BMC Cell Biology, 2009
Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Frosst Phyllis D, Ben-Efraim Iris, Gerace Larry   +2 more
doaj   +1 more source

Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α*

Journal of Biological Chemistry, 2007
The best understood system for the transport of macromolecules between the cytoplasm and the nucleus is the classical nuclear import pathway. In this pathway, a protein containing a classical basic nuclear localization signal (NLS) is imported by a ...
A. Lange, R. Mills, Christoph Lange, M. Stewart, S. Devine, A. Corbett   +5 more
semanticscholar   +1 more source

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions

Biochemical Journal, 2020
The carbohydrate response element binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis.
Hun-Min Jung, T. Takeshima, T. Nakagawa, Karen S Macmillan, R. M. Wynn, Han-Zhi Wang, Haruhiko Sakiyama, Shu-Guang Wei, Yang Li, R. Bruick, B. Posner, J. D. De Brabander, K. Uyeda   +12 more
semanticscholar   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Importin beta validates human importin beta as a cell cycle negative regulator-2

, 2011
Ontain no nuclear pores (left panel), when diluted into fresh cytosol (+ buffer), incorporate nuclear pores. The addition of His-tagged human importin beta (+h-β-Tag) or untagged importin beta (+X-β) prevented nuclear pore assembly.
Rene C Chan (63112), Valerie A Delmar (63111), Douglass J Forbes (63113)   +2 more
core   +1 more source

Importin β4 Mediates Nuclear Import of GRF-Interacting Factors to Control Ovule Development in Arabidopsis1[OPEN]

Plant Physiology, 2019
An importin β regulates nucleocytoplasmic transport of Arabidopsis transcriptional co-activators GIFs, and by doing so, it regulates ovule development. Ovule development is critical for seed development and plant reproduction.
Hai-Hong Liu, Feng Xiong, Cun-Ying Duan, Ya-Nan Wu, Yan Zhang, Sha Li   +5 more
semanticscholar   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Drosophila Notch binds Importin-α3.

, 2013
(A) Schematic representation of the domain organization of Importin-α3. Different domains and boundary residues are marked on top. IBB, Importin β binding domain; ARM, Armadillo repeats [see refs 19, 20].
Nalani Sachan (428990), Mousumi Mutsuddi (323156), Abhinava K. Mishra (428991), Ashim Mukherjee (53857)   +3 more
core   +1 more source