Results 101 to 110 of about 21,607 (213)

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Investigation of signal dependent nuclear transport of DFF (DNA-Fragmentation-Factor) by Importin alpha 3/Importin beta [PDF]

, 2008
In dieser Arbeit wurden die Kernlokalisationssequenzen der Untereinheiten des DFF-Komplexes, der murinen Nuklease CAD und des humanen und murinen Inhibitors DFF45/ICAD-L, anhand von fluoreszenzmikroskopischen Untersuchungen untersucht und klassifiziert ...
Müller, Wibke
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

KPNB1 (karyopherin (importin) beta 1) [PDF]

, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is ...
Leaner, V, Lavia, P, Giubettini, M, van, der Watt P, Verrico, A, de, Turris V   +5 more
core   +1 more source

Biobanking efforts and new advances in male fertility preservation for rare and endangered species

Asian Journal of Andrology, 2015
Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
doaj   +1 more source

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.

ACS Infectious Diseases, 2019
The Zika virus (ZIKV) epidemic in the Americas was alarming because of its link with microcephaly in neonates and Guillain-Barré syndrome in adults. The unusual pathologies induced by ZIKV infection and the knowledge that the flaviviral nonstructural ...
Ivan H. W. Ng, K. Chan, M. Tan, C. P. Gwee, Kate M. Smith, S. Jeffress, W. Saw, C. Swarbrick, Satoru Watanabe, D. Jans, Gerhard Grüber, J. Forwood, S. Vasudevan   +12 more
semanticscholar   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

miR181b-3p and its target importin α5 regulate TLR4 signaling in Kupffer cells and liver injury in mice in response to ethanol

Hepatology, 2017
Increased inflammatory signaling by Kupffer cells contributes to alcoholic liver disease (ALD). Here we investigated the impact of small, specific‐sized hyaluronic acid of 35 kD (HA35) on ethanol‐induced sensitization of Kupffer cells, as well as ethanol‐
Paramananda Saikia, Damien A. Bellos, Megan R. McMullen, K. Pollard, C. de la Motte, Laura E. Nagy   +5 more
semanticscholar   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Importin beta validates human importin beta as a cell cycle negative regulator-1

, 2011
Cked nuclear membrane fusion, as shown by the lack of a solid nuclear rim stain by the green fluorescent membrane dye DHCC. The block to membrane fusion could be rescued by the addition of RanQ69L-GTP (+X-β +Ran).
Rene C Chan (63112), Valerie A Delmar (63111), Douglass J Forbes (63113)   +2 more
core   +1 more source