Results 101 to 110 of about 16,651 (218)

Binding of NP to importin α.

, 2013
(A) Purification of mRFP-Flag-tagged WT and mutant NP110aas from COS-7 cells and GST-tagged importin α isoforms, Rch1, Qip1 and NPI-1 from Escherichia coli.
Yutaka Sasaki (286423), Kazunori Yamada (286428), Kyoji Hagiwara (286424), Yoko Aida (179321), Michinori Kakisaka (286426), Tomoyuki Murakami (195979)   +5 more
core   +1 more source

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.

, 1996
The complex of importin-alpha and -beta is essential for nuclear protein import. It binds the import substrate in the cytosol, and the resulting trimeric complex moves through the nuclear pores, probably as a single entity.
Laskey, R. A., Hartmann, E., Laskey, R., Görlich, D., Henklein, P., Goerlich, D., Laskey, R.A.   +6 more
core  

Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector [PDF]

, 2015
Importin-αs are essential adapter proteins that recruit cytoplasmic proteins destined for active nuclear import to the nuclear transport machinery. Cargo proteins interact with the importin-α armadillo repeat domain via nuclear localization sequences ...
Wirthmueller, Lennart, Roth, Charlotte, Jones, Jonathan D. G., Fabro, Georgina, Jonathan D. G. Jones, Banfield, Mark J., Georgina Fabro, Shuta Asai, Wiermer, Marcel, Caillaud, Marie-Cécile, Charlotte Roth, Jones, Alexandra M., Marie‐Cécile Caillaud, Marcel Wiermer, Lennart Wirthmueller, Jones, Alexandra M. E., Asai, Shuta, Alexandra M. E. Jones, Rallapalli, Ghanasyam, Ghanasyam Rallapalli, Sklenar, Jan, Mark J. Banfield, Jan Sklenar   +22 more
core   +1 more source

Investigation of signal dependent nuclear transport of DFF (DNA-Fragmentation-Factor) by Importin alpha 3/Importin beta

, 2008
In dieser Arbeit wurden die Kernlokalisationssequenzen der Untereinheiten des DFF-Komplexes, der murinen Nuklease CAD und des humanen und murinen Inhibitors DFF45/ICAD-L, anhand von fluoreszenzmikroskopischen Untersuchungen untersucht und klassifiziert ...
Müller, Wibke
core   +1 more source

The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency

Molecular Systems Biology, 2007
Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin‐α (Impα), which links the cargo to a karyopherin, Importin‐β (Impβ). The reason for the existence of
Greg Riddick, Ian G Macara
doaj   +1 more source

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation

Molecular Oncology
The mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 5 (ERK5) is emerging as a promising target in cancer. Indeed, alterations of the MEK5/ERK5 pathway are present in many types of cancer, including melanoma.
Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida   +10 more
doaj   +1 more source

Regulation of nuclear localization signal-importin α interaction by Ca2+/S100A6

, 2010
Although the precise intracellular roles of S100 proteins are not fully understood, these proteins are thought to be involved in Ca2+-dependent diverse signal transduction pathways.
Tokuda, Masaaki, Kobayashi, Ryoji, Fuminori Yamaguchi, Tokumitsu, Hiroshi, Masaaki Tokuda, Maki Takata, Ryoji Kobayashi, Takata, Maki, Shimamoto, Seiko, Yamaguchi, Fuminori, Seiko Shimamoto, Hiroshi Tokumitsu   +11 more
core   +1 more source

A sejtmagi fehérje-import Importin-alfa2 faktorának citoplazmatikus funkciói = Cytoplasmic functions of Importin-alpha2, a factor of nuclear protein import

, 2011
Az importin-alfa2D14 + / + importin-ßKetelRE34 Drosophila nőstényektől származó embriók letálisak. Jellemeztük a maternális interakciót. Főbb eredményeink: - embrió letalitás a szinciciális blasztoderma állapotban a metafázisban blokkolt osztódási orsó
Kiss, István, Szlanka, Tamás
core  

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Nature Communications, 2018
Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the ...
Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler, Jade K. Forwood   +8 more
doaj   +1 more source

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

, 1997
NLS proteins are transported into the nucleus by the importin α/β heterodimer. Importin α binds the NLS, while importin β mediates translocation through the nuclear pore complex.
Kutay, Ulrike, Görlich, Dirk, Kutay, U., Bischoff, F. R., Bischoff, F.Ralf, Kostka, S., Görlich, D., Kostka, Susanne, Goerlich, D., Kraft, Regine, Kraft, R., Bischoff, F.R.   +11 more
core   +1 more source