Results 121 to 130 of about 29,175 (219)

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation

Molecular Oncology
The mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 5 (ERK5) is emerging as a promising target in cancer. Indeed, alterations of the MEK5/ERK5 pathway are present in many types of cancer, including melanoma.
Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida   +10 more
doaj   +1 more source

Importin Beta [PDF]

Molecular Cell, 2004
Harel, Amnon, Forbes, Douglass J.
openaire   +1 more source

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Nature Communications, 2018
Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the ...
Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler, Jade K. Forwood   +8 more
doaj   +1 more source

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

The EMBO Journal
Sphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation.
Vaishali Jayashankar, Peter Kubiniok, Alison N McCracken, Rebeca G Gentry, Kazumi H Eckenstein, Lorenzo Sernissi, Vito Vece, Jean-Baptiste Garsi, Sarah Y Valles, Sunhee Jung, Natalie C Hoffman, Arielle S Perrochon, Elizabeth M Selwan, Brendan T Finicle, Mary Pitman, DaWei Lin, Éric Bonneil, Ruijuan Xu, Cungui Mao, Peter Kaiser, David A Fruman, David Mobley, Cholsoon Jang, Stephen Hanessian, Pierre Thibault, Aimee L Edinger   +25 more
doaj   +1 more source

Nucleocytoplasmic transport: taking an inventory [PDF]

, 2018
In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial and temporal separation of DNA replication and transcription from cytoplasmic protein synthesis.
Fried, H., Kutay, U.
core  

CDK9 interacts with a RanGTP-importin-β complex to regulate erythroid enucleation. [PDF]

J Cell Sci
Newton LM, Lim KYB, Abeid DY, Wölwer CB, Johnson CJ, Russell SM, Hawkins ED, Humbert PO.   +7 more
europepmc   +1 more source

Unveiling nuclear localization signals in human arginine deiminase proteins. [PDF]

Protein Sci
Neira JL, Abian O, Velazquez-Campoy A, Rizzuti B.   +3 more
europepmc   +1 more source

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins. [PDF]

Bioessays
Bernardes N, Chook YM.
europepmc   +1 more source

Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex. [PDF]

Cell Mol Life Sci
Kong X, Liu J, Zhu Q, Xu S.
europepmc   +1 more source

Structural insights into the nuclear import of ovine gammaherpesvirus 2 ORF73 LANA homologue. [PDF]

J Gen Virol
Nath BK, Schwab RHM, Swarbrick CMD, Pavan S, Rahman N, McSharry BP, Raidal SR, Ariawan D, Tietz O, Das S, Alvisi G, Forwood JK.   +11 more
europepmc   +1 more source