Results 111 to 120 of about 21,607 (213)
Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling [PDF]
, 2012 SummarySubcellular localization of mRNA enables compartmentalized regulation within large cells. Neurons are the longest known cells; however, so far, evidence is lacking for an essential role of endogenous mRNA localization in axons.
McDonald, Marguerite K. +12 more
core +1 more source
The role of Importin-βs in the maintenance and lineage commitment of mouse embryonic stem cells
FEBS Open Bio, 2014 Members of the Importin-β family recognize nuclear localization signals (NLS) and nuclear export signals (NES). These proteins play important roles in various nucleocytoplasmic transport processes in cells. Here, we examined the expression patterns of 21
Percival Sangel +2 more
doaj +1 more source
Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid +8 more
wiley +1 more source
Structural and biochemical characterization of the Importin-β·Ran·GTP·RanBD1 complex [PDF]
, 2007 Here we present the crystal structure of Importin-β(1–462)·Ran·GTP·RanBD1ΔN as solved by molecular replacement. HPLC dissociation measurements on this complex show, that the N-terminus of RanBD may be involved in the release of the hydrolysis- and ...
Kuhlmann, J. +11 more
core +1 more source
Unmasking the Influence of Viral Micro‐RNAs on Host Immunity
Immunology &Cell Biology, EarlyView.Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton +1 more
wiley +1 more source
Demonstration of a direct interaction of importin-α4 or importin-α7 with XPA in vitro.
, 2013 A. In vitro interaction of importin-α4 and XPA. (a) A diagrammatic illustration of experimental procedures. H1299 cells were mock or UV-C irradiated (20 J/m2) followed by a ½ h recovery.
Hui Wang (30400) +4 more
core +1 more source
Asian Journal of Andrology, 2015 Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland +5 more
doaj +1 more source
RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking
bioRxiv, 2019 High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin α/β.
S. Ems-McClung +5 more
semanticscholar +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat +11 more
wiley +1 more source
Importin β interaction with GST-Cp183 fusion protein.
, 2016 (a) Confocal fluorescence microscopy of importin α-Alexa594 and importin β-Alexa488 with glutathione sepharose, coated with different GST fusion proteins. The protein coating the beads is indicated on the left.
Joseph Che-Yen Wang (195672) +9 more
core +1 more source