Results 111 to 120 of about 16,651 (218)
Structural and biochemical characterization of the Importin-β·Ran·GTP·RanBD1 complex
, 2007 Here we present the crystal structure of Importin-β(1–462)·Ran·GTP·RanBD1ΔN as solved by molecular replacement. HPLC dissociation measurements on this complex show, that the N-terminus of RanBD may be involved in the release of the hydrolysis- and ...
Kuhlmann, J. +11 more
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Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling
, 2012 SummarySubcellular localization of mRNA enables compartmentalized regulation within large cells. Neurons are the longest known cells; however, so far, evidence is lacking for an essential role of endogenous mRNA localization in axons.
McDonald, Marguerite K. +12 more
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Importin beta regulates mitosis via distinct molecular mechanisms
, 2018 Importin beta is the major vector for protein import in interphase nuclei and acts as an effector of the GTPase RAN. After nuclear envelope breakdown, when nuclear transport ceases, Importin beta acts in control of mitosis. Importin beta is overexpressed
VERRICO, ANNALISA
core
, 2006 The 'classical' nuclear protein import pathway depends on importin alpha and importin beta. Importin alpha binds nuclear localization signal (NLS)-bearing proteins and functions as an adapter to access the importin beta dependent import pathway.
Sommer, T. +4 more
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Model for importin 7- and Nup358-assisted import of hTERT.
, 2014 Cytoplasmic hTERT (TERT) interacts with Nup358, the major component of the cytoplasmic filaments of the NPC (blue rods). Upon binding of importin 7, hTERT is translocated across the NPC.
Sarah Wälde (525477) +4 more
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Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro [PDF]
Importin alpha is well known as an adaptor that functions with Importin beta in the nuclear import of proteins containing specific nuclear localization signals (NLSs). We show here that either an excess or a lack of Importin alpha blocks nuclear envelope
Köcher, Thomas +3 more
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The EMBO JournalSphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation.
Vaishali Jayashankar +25 more
doaj +1 more source
Distinct energy requirement for nuclear import and export of importin β in living cells
, 1999 Importin β can shuttle between the nucleus and cytoplasm through the nuclear pore complex (NPC). This study deals with the issue of how the energy is utilized during the NPC passage of importin β.
Naoko Imamoto +5 more
core +1 more source
Differential recognition of canonical NF-κB dimers by Importin α3
, 2022 Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the p65-nuclear localization sequence (NLS).
Cingolani, Gino +6 more
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