Results 91 to 100 of about 21,607 (213)

Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells

Scientific Reports
Interleukin-1α (IL-1α), a cytokine released by necrotic cells, causes sterile inflammation. On the other hand, IL-1α is present in the nucleus and also regulates the expression of many proteins.
Akiko Yamada, Kiyotaka Wake, Saya Imaoka, Mitsuru Motoyoshi, Takenori Yamamoto, Masatake Asano   +5 more
doaj   +1 more source

Increased importin α protein expression in diabetic nephropathy [PDF]

, 2001
Increased importin α protein expression in diabetic nephropathy.BackgroundImportins transport kinases, transcription factors, and viral proteins into the nucleus.
Koehler, M., Mervaala, Eero M.A., Samoilova, Vera, Shagdarsuren, E., Hartmann, E., Haller, H., Haller, Hermann, Buchwalow, Igor B., Shagdarsuren, Erdenechimeg, Christiansen, M., Hartmann, Enno, Alexander, G., Alexander, Gabriele, Köhler, Matthias, Mervaala, E.M.A., Samoilova, V., Christiansen, Marret, Buchwalow, I.B.   +17 more
core   +1 more source

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Nature Communications, 2018
Seven human isoforms of importin α mediate nuclear import of cargo in a tissue- and isoform-specific manner. How nuclear import adaptors differentially interact with cargo harbouring the same nuclear localisation signal (NLS) remains poorly understood ...
Kate M. Smith, S. Tsimbalyuk, M. Edwards, E. Cross, J. Batra, T. P. Soares da Costa, D. Aragão, C. Basler, J. Forwood   +8 more
semanticscholar   +1 more source

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. [PDF]

, 1996
The complex of importin-alpha and -beta is essential for nuclear protein import. It binds the import substrate in the cytosol, and the resulting trimeric complex moves through the nuclear pores, probably as a single entity.
Laskey, R. A., Hartmann, E., Laskey, R., Görlich, D., Henklein, P., Goerlich, D., Laskey, R.A.   +6 more
core  

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

eLife, 2020
Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes, Lauren Duan, Kelly Bowen, Petr Kalab, Jeffrey D Rothstein   +4 more
doaj   +1 more source

Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α

Nature Communications, 2019
To facilitate proper mitotic cell partitioning, the Golgi disassembles by suppressing vesicle fusion. However, the underlying mechanism has not been characterized previously.
Chih-Chia Chang, Ching-Jou Chen, Cédric Grauffel, Y.-C. Pien, C. Lim, S. Tsai, K. Hsia   +6 more
semanticscholar   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Binding parameters of h-importin-α1 and ΔIBB-h-importin-α1 by ITC.

, 2015
KD: dissociation constant,N: number of binding sites,ΔH: binding enthalpy,N.D. not detectable.Binding parameters of h-importin-α1 and ΔIBB-h-importin-α1 by ITC.
Yuko Tatsumi (690327), Akira Sanjoh (690325), Yoko Aida (179321), Satoru Unzai (690326), Hideyuki Miyatake (690324), Yoichi Miyamoto (122118), Naoshi Dohmae (85096), Go Matsuda (195986)   +7 more
core   +1 more source

Viruses Challenge Selectivity Barrier of Nuclear Pores

Viruses, 2013
Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
doaj   +1 more source

Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly

Journal of Cell Science, 2019
Importin-α serves as an adaptor linking importin-β to proteins carrying a nuclear localization sequence (NLS). During interphase, this interaction enables nuclear protein import, while in mitosis it regulates spindle assembly factors (SAFs) and controls ...
Li Guo, K. S. Mohd, H. Ren, Guang-Wei Xin, Qing Jiang, P. Clarke, Chuanmao Zhang   +6 more
semanticscholar   +1 more source