Results 91 to 100 of about 16,651 (218)

Demonstration of a direct interaction of importin-α4 or importin-α7 with XPA in vitro.

, 2013
A. In vitro interaction of importin-α4 and XPA. (a) A diagrammatic illustration of experimental procedures. H1299 cells were mock or UV-C irradiated (20 J/m2) followed by a ½ h recovery.
Hui Wang (30400), Phillip R. Musich (337656), Yue Zou (15851), Zhengke Li (337655), Brian M. Cartwright (431428)   +4 more
core   +1 more source

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

Asian Journal of Andrology, 2015
Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland, Andrew T. Major, Romaly Butler, Julia C. Young, David A. Jans, Yoichi Miyamoto   +5 more
doaj   +1 more source

MYB Factors: Hubs of Plant Stress and Hormone Crosstalk

Plant Biotechnology Journal, EarlyView.
ABSTRACT MYB transcription factors function as main regulatory hubs that integrate environmental signals with multi‐hormonal pathways to synchronize plant growth, metabolism and stress responses. This review delineates the regulatory roles of MYB in the signalling pathway of salicylic acid, jasmonic acid, ethylene and abscisic acid signalling.
Aye Aye Htun, Ya Wang, Jiahao Liu, Zhiqiang Guo, Yi Zheng, Wenjie Wang, Shuting Ma, Aolin Jia, Yan Ren, Feng Chen   +9 more
wiley   +1 more source

A muscular dystrophy associated with bi‐allelic LEMD2 variants: Expanding the genotype of nuclear envelopathies

Brain Pathology, Volume 36, Issue 4, July 2026.
Proteomics‐guided exome re‐analysis identifies bi‐allelic variants in the nuclear envelope LEMD2 gene, expanding its phenotypic spectrum. Created in BioRender. Pauper, M. (2026) https://BioRender.com/xamvo92.
Marc Pauper, Heike Kölbel, Iakowos Karakesisoglou, Anne Schänzer, Johann Böhm, Rachel Thompson, Nicolai Kohlschmidt, Bernd Ringel, Gisèle Bonne, Katja Neuhoff, Andrea Gangfuß, Ozge Aksel Kilicarslan, Sergi Beltran Agullo, Andreas Hentschel, Ulrike Schara‐Schmidt, Hanns Lochmüller, Kiran Polavarapu, Andreas Roos   +17 more
wiley   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

Importin beta validates human importin beta as a cell cycle negative regulator-4

, 2011
In beta with 94% identities (828/876, black boxes) and 97% positives (857/876 gray and black boxes). The amino acid composition, along with the length of the protein, is well conserved between and human importin beta. Three of the conservative amino acid
Rene C Chan (63112), Valerie A Delmar (63111), Douglass J Forbes (63113)   +2 more
core   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Regulation of mitotic spindle assembly factor NuMA by Importin-β

, 2017
Ran–guanosine triphosphatase orchestrates mitotic spindle assembly by modulation of the interaction between Importin-α/-β and spindle assembly factors (SAFs).
Tzu-Lun Huang, Su-Yi Tsai, Chih-Chia Chang, Yuta Shimamoto, Kuo-Chiang Hsia   +4 more
core   +1 more source

Increased importin α protein expression in diabetic nephropathy

, 2001
Increased importin α protein expression in diabetic nephropathy.BackgroundImportins transport kinases, transcription factors, and viral proteins into the nucleus.
Koehler, M., Mervaala, Eero M.A., Samoilova, Vera, Shagdarsuren, E., Hartmann, E., Haller, H., Haller, Hermann, Buchwalow, Igor B., Shagdarsuren, Erdenechimeg, Christiansen, M., Hartmann, Enno, Alexander, G., Alexander, Gabriele, Köhler, Matthias, Mervaala, E.M.A., Samoilova, V., Christiansen, Marret, Buchwalow, I.B.   +17 more
core   +1 more source

Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope

Biology Open, 2015
The formin family proteins are important regulators of actin polymerization that are involved in many cellular processes. However, little is known about their specific cellular localizations.
Xiaowei Shao, Keiko Kawauchi, G. V. Shivashankar, Alexander D. Bershadsky   +3 more
doaj   +1 more source