Results 91 to 100 of about 9,891 (213)

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

Asian Journal of Andrology, 2015
The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo, Josep Maria Estanyol, Josep Lluis Ballescà, Rafael Oliva   +3 more
doaj   +1 more source

Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling

Journal of Ovarian Research, 2021
Background Karyopherin α-2 (KPNA2) is a member of karyopherin family, which is proved to be responsible for the import or export of cargo proteins. Studies have determined that KPNA2 is associated with the development and prognosis of various cancers ...
Xiangrong Cui, Honghong Wang, Xueqing Wu, Kai Huo, Xuan Jing   +4 more
doaj   +1 more source

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors [PDF]

, 2013
Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are
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core   +2 more sources

Karyopherins in nuclear transport of homeodomain proteins during development

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking.
Ye, Wenduo, Lin, Wenbo, Tartakoff, Alan M., Tao, Tao   +3 more
openaire   +3 more sources

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

New insights into the regulation of cholesterol efflux from the sperm membrane

Asian Journal of Andrology, 2015
Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
doaj   +1 more source

Take your mother’s ferry: preimplantation embryo development requires maternal karyopherins for nuclear transport

The Journal of Clinical Investigation, 2023
The genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this issue of the JCI, Wang, Miyamoto, et
Momal Sharif, Laura Detti, Ignatia B. Van den Veyver   +2 more
doaj   +1 more source

Interactome mapping reveals the evolutionary history of the nuclear pore complex [PDF]

, 2016
The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Brillantes, Marc, Chait, Brian T., Field, Mark C., Ketaren, Natalia E., Obado, Samson O., Rout, Michael P., Uryu, Kunihiro, Zhang, Wenzhu   +7 more
core   +5 more sources

Intermolecular disulfide bonds among nucleoporins regulate karyopherin-dependent nuclear transport [PDF]

Journal of Cell Science, 2013
Disulfide (S-S) bonds play important roles in the regulation of protein function and cellular stress responses. In this study, we demonstrate that distinct sets of nucleoporins (Nups), components of the nuclear pore complex (NPC), form S-S bonds and regulate nuclear transport through the NPC.
Shige H, Yoshimura, Shotaro, Otsuka, Masahiro, Kumeta, Mariko, Taga, Kunio, Takeyasu   +4 more
openaire   +2 more sources

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, Volume 12, Issue 35, September 18, 2025.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source