Results 91 to 100 of about 6,082 (161)

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer [PDF]

, 2013
The apoptosis signal-regulating kinase 1 (ASK1) is activated in response to a wide variety of extracellular stressors. Consequently, dysregulation of ASK1 is associated with multiple pathologies. Here, we show that ASK1 translocates from the cytoplasm to
Chen, Weimin, Duckett, Derek, Feurstein, Daniel, Sturchler, Emmanuel, McDonald, Patricia   +4 more
core   +1 more source

A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion

, 2019
Human karyopherin beta 3, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway.
Cha, SS, Jang, SK, Chung, KM
core  

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B

Cells
The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Jacques S. Fritze, Felizitas F. Stiehler, Uwe Wolfrum   +2 more
doaj   +1 more source

Karyopherin alpha expression in porcine tissue

, 2013
The cell must modify expression of certain genes in order to respond appropriately to environmental and internal stimuli. In order for signaling molecules to exert their regulatory effects, they must first gain access to the nucleus, where transcription ...
Hall, Dominique Alexis
core   +1 more source

Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin β and Ran for nucleocytoplasmic trafficking

, 2010
The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor (OGFr) form an endogenous and tonically active growth-regulating system that modulates cell proliferation by upregulating the cyclin-dependent kinase inhibitory pathway.
Ian S Zagon, Patricia J McLaughlin, Fan Cheng   +2 more
core   +1 more source

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

BMC Cancer, 2018
Background Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer.
Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi   +3 more
doaj   +1 more source

Macrocyclic peptide inhibitors for the protein–protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5

, 2017
Describes the identification of macrocyclic peptide inhibitors of the ebola VP24 protein–karyopherin alpha 5 protein–protein interaction with nanomolar affinity for VP24.
Lu-yi Lu, Hiroaki Suga, Xiao Song, Toby Passioura   +3 more
core   +1 more source

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways

Viruses
Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Richard W. Wong   +4 more
doaj   +1 more source

Xenobiotic-dependent regulation of human karyopherin A2 (KPNA2) gene. [PDF]

, 2018
A common reaction to xenobiotic exposure is the modulation of genes that mediate the response to such insult, including the drug metabolising enzymes and drug transporters.
Cheema, Manraj Singh.
core  

Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation

, 2020
Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism and/or the health of their ...
Palacios, Victor Manuel
core