Results 91 to 100 of about 5,815 (206)
Nuclear Import of Yeast Proteasomes
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
doaj +1 more source
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection. [PDF]
PLoS Pathogens, 2018 Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%.
Javier Canton +8 more
doaj +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, with cellular senescence playing a context‐dependent role in tumor progression and the immunosuppressive microenvironment. This study is aimed at identifying senescence‐related gene signatures through integrated single‐cell and transcriptomic ...
Kai Yu +10 more
wiley +1 more source
Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Cells, 2018 Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
doaj +1 more source
Health Benefits and Therapeutic Potential of Quercetin
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley +1 more source
Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng +6 more
wiley +1 more source
Karyopherin alphas in canonical nuclear import.
, 2017 (A) In canonical import, a karyopherin α (Kpna) binds to both the nuclear localization sequence-containing cargo protein and to Kpnb. Subsequently, Kpnb interacts with the nuclear pore to bring the trimeric complex into the nucleus.
Chi Zhang (9857) +4 more
core +1 more source
, 2022 Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung ...
Trudy G. Oliver (14957133) +19 more
core +1 more source
The HIV capsid mimics karyopherin engagement of FG-nucleoporins. [PDF]
NatureAbstractHIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central
Dickson CF +12 more
europepmc +6 more sources
Small Science, Volume 5, Issue 11, November 2025.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source