Results 111 to 120 of about 5,815 (206)

Karyopherin α deficiency contributes to human preimplantation embryo arrest

The Journal of Clinical Investigation, 2023
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang   +31 more
doaj   +1 more source

A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion

, 2008
Human karyopherin beta 3, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway.
Chung, Kyung Min, Cha, Sun-Shin, Jang, Sung Key   +2 more
core  

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

, 2014
CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID.
Telerman, Stephanie B, Ganesh, Karuna, Johnson, Christopher M, Johnson, Christopher M., Simpson, Paul, Williams, Roger L., Maldegem, Febe van, Rada, Cristina, Williams, Roger L, Telerman, Stephanie B., Neuberger, Michael S, van Maldegem, Febe, Neuberger, Michael S.   +12 more
core   +1 more source

Nuclear Transport of Yeast Proteasomes

Biomolecules, 2014
Proteasomes are conserved protease complexes enriched in the nuclei of dividing yeast cells, a major site for protein degradation. If yeast cells do not proliferate and transit to quiescence, metabolic changes result in the dissociation of proteasomes ...
Cordula Enenkel
doaj   +1 more source

A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion

, 2019
Human karyopherin beta 3, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway.
Cha, SS, Jang, SK, Chung, KM
core  

The distribution of karyopherin β proteins in Alzheimer's disease

The FASEB Journal, 2008
Electron microscopic studies of Alzheimer's disease (AD) revealed an intimate relationship between paired helical filaments and nuclear pores, structures with a key role in bidirectional nucleocytoplasmic transport. This association led us to explore potential abnormalities in transport that may contribute to tangle formation and other protein ...
Lynette G Sheffield, Suzanne S Mirra
openaire   +1 more source

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B

Cells
The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Jacques S. Fritze, Felizitas F. Stiehler, Uwe Wolfrum   +2 more
doaj   +1 more source

Karyopherin alpha seven and porcine embryo development

, 2012
Coordinated partitioning of intracellular cargoes between nuclear and cytoplasmic compartments is critical for cell survival and differentiation. The karyopherin α/β heterodimer functions to import cytoplasmic proteins that possess classical nuclear ...
Wang, Xin
core  

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

BMC Cancer, 2018
Background Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer.
Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi   +3 more
doaj   +1 more source

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

, 1998
Background: Control of the nuclear localization of specific proteins is an important mechanism for regulating many signal transduction pathways. Upon activation of the Wnt signaling pathway, β-catenin localizes into the nucleus and interacts with TCF/LEF-
Gumbiner, Barry M., François Fagotto, Barry M. Gumbiner, Ursula Glück, Fagotto, F. ; https://orcid.org/, Glück, U., Glück, Ursula, Gumbiner, B., Fagotto, François   +8 more
core   +1 more source