Results 121 to 130 of about 5,815 (206)
Karyopherin alpha expression in porcine tissue
, 2013 The cell must modify expression of certain genes in order to respond appropriately to environmental and internal stimuli. In order for signaling molecules to exert their regulatory effects, they must first gain access to the nucleus, where transcription ...
Hall, Dominique Alexis
core
, 2013 The apoptosis signal-regulating kinase 1 (ASK1) is activated in response to a wide variety of extracellular stressors. Consequently, dysregulation of ASK1 is associated with multiple pathologies. Here, we show that ASK1 translocates from the cytoplasm to
Chen, Weimin +4 more
core +1 more source
Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways
VirusesViruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang +4 more
doaj +1 more source
Signals and blockers in karyopherin‐mediated transport (238.1)
The FASEB Journal, 2014 Karyopherinβ (Kap; Importin or Exportin) proteins mediate nucleocytoplasmic transport. Individual Kaps transport unique sets of cargos through recognition of distinct nuclear localization or export signals (NLSs or NESs). Although there are 19 known Kaps in humans, only four classes of signals are known at this time: the short basic classical‐NLS, the ...
openaire +1 more source
Recombinant GST-SP17 and GST-RREB interact with multiple karyopherin α subtypes.
, 2013 S35-labeled versions of porcine KPNA1, KPNA2, KPNA3, KPNA5, KPNA6, and KPNA7 were tested for their ability to interact with GST, GST-SP17, GST-RREB, GST-NLS, and a GST tagged version of karyopherin β (KPNB).
H. Dorota Inerowicz (319648) +5 more
core +1 more source
Karyopherin alphas are widely expression in OLP and important regulators of OL differentiation.
, 2017 (A)Kpna gene expression in OLP exposed only to proliferative factors (PDGFAA, 10 ng/ml and bFGF, 20 ng/ml) for 24h. Expression was quantified from isolated total RNA with NanoString nCounter Gene Expression Assay.
Chi Zhang (9857) +4 more
core +1 more source
, 2019 Background: Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm.
Singer S. +12 more
core +1 more source
Xenobiotic-dependent regulation of human karyopherin A2 (KPNA2) gene.
, 2018 A common reaction to xenobiotic exposure is the modulation of genes that mediate the response to such insult, including the drug metabolising enzymes and drug transporters.
Cheema, Manraj Singh.
core
Evolutionary and Transcriptional Exploration of Karyopherin β superfamily proteins [PDF]
, 2009 β核转运蛋白家族是真核细胞中广泛存在的一类蛋白质，在生物大分子核质转运这一细胞过程中扮演着关键角色。由于β核转运蛋白家族各成员间序列组成及结构上的差异，其所携带的底物及工作机制也有所不同。目前国际上对该家族的研究尚浅，对其家族的形成及功能演化也尚未明晰。在本研究中，我们利用系统发育分析，表达谱芯片分析，转录因子调控位点预测等方法，对酿酒酵母，秀丽隐杆线虫，黑腹果蝇，斑马鱼，爪蟾，原鸡，小鼠和人类基因组中β核转运蛋白家族成员开展了进化、表达和基因调控模式分析。在酵母的14个家族成员中，8个成员（KAP95,
全宇
core
Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
, 2020 Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism and/or the health of their ...
Palacios, Victor Manuel
core