Results 121 to 130 of about 9,891 (213)
Journal of Experimental & Clinical Cancer Research, 2019 Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang +7 more
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The karyopherin CRM1 is required for dendritic cell maturation
Immunobiology, 2010 Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz +4 more
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From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR [PDF]
, 2015 Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable.
Packham, Sylvia
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Nuclear Transport of Yeast Proteasomes
Biomolecules, 2014 Proteasomes are conserved protease complexes enriched in the nuclei of dividing yeast cells, a major site for protein degradation. If yeast cells do not proliferate and transit to quiescence, metabolic changes result in the dissociation of proteasomes ...
Cordula Enenkel
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The design and synthesis of nuclear localization signal (NLS) mimics [PDF]
, 1998 Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the ...
Ho, Thai Huu
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Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport [PDF]
, 2019 The Glutamate Receptor Ionotropic NMDA-Associated Protein 1 (GRINA) belongs to the Lifeguard family and is involved in calcium homeostasis, which governs key processes, such as cell survival or the release of neurotransmitters. GRINA is mainly associated
García Quintanilla, Alberto +3 more
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Calcium mediated regulation of karyopherin nuclear transport receptors
The FASEB Journal, 2013 Oxidative stress disrupts the normal function of cells and severe stress situations can result in apoptosis. A specific effect of oxidant stress is an increase in cellular calcium levels, which can be mimicked by treatment with the drug thapsigargin, which inhibits Ca 2+ uptake into the ...
Lauren Elizabeth Foltz +3 more
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Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B
CellsThe USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Jacques S. Fritze +2 more
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BMC Cancer, 2018 Background Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer.
Elisa M. Vuorinen +3 more
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Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Inactivation of S. cerevisiae β-karyopherin Msn5 causes hypersensitivity to the overexpression of mitotic cyclin Clb2 and aggravates growth defects of many mutant strains in mitotic exit, suggesting a connection between Msn5 and mitotic exit. We determined that Msn5 controlled subcellular localization of the mitotic exit transcription factor Swi5 ...
Taberner, Francisco José +4 more
openaire +2 more sources