Results 101 to 110 of about 9,891 (213)
Nuclear Transport of Yeast Proteasomes
Frontiers in Molecular Biosciences, 2019 Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP).
Petra Wendler, Cordula Enenkel
doaj +1 more source
Comparative interactomics provides evidence for functional specialization of the nuclear pore complex [PDF]
, 2017 The core architecture of the eukaryotic cell was established well over one billion years ago, and is largely retained in all extant lineages. However, eukaryotic cells also possess lineage-specific features, frequently keyed to specific functional ...
Field, Mark C. +2 more
core +2 more sources
A 3D Physical Model of Karyopherin‐β2
The FASEB Journal, 2012 Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong +12 more
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Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions
MedComm, Volume 6, Issue 9, September 2025.Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu +3 more
wiley +1 more source
Nuclear Import of Yeast Proteasomes
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
doaj +1 more source
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection. [PDF]
PLoS Pathogens, 2018 Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%.
Javier Canton +8 more
doaj +1 more source
Viral oncolysis that targets raf-1 signaling control of nuclear transport [PDF]
, 2013 The central role of Raf protein kinase isoforms in human cancer demands specific anti-Raf therapeutic inhibitors. Parvoviruses are currently used in experimental cancer therapy due to their natural oncotropism and lytic life cycle.
Almendral, José M. +5 more
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Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance
MedComm, Volume 6, Issue 9, September 2025.Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu +7 more
wiley +1 more source
Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Cells, 2018 Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
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Molecular basis for protection of ribosomal protein L4 from cellular degradation [PDF]
, 2017 Eukaryotic ribosome biogenesis requires the nuclear import of ∼80 nascent ribosomal proteins and the elimination of excess amounts by the cellular degradation machinery.
Hoelz, André, Huber, Ferdinand M.
core +1 more source