Results 101 to 110 of about 5,815 (206)

The role of Karyopherin β1 in the nuclear import of HIV-1 proteins

, 2014
Includes abstract.
Shaw, Tamlyn Marion
core  

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Macrocyclic peptide inhibitors for the protein–protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5

, 2017
Describes the identification of macrocyclic peptide inhibitors of the ebola VP24 protein–karyopherin alpha 5 protein–protein interaction with nanomolar affinity for VP24.
Lu-yi Lu, Hiroaki Suga, Xiao Song, Toby Passioura   +3 more
core   +1 more source

Karyopherins in nuclear transport of homeodomain proteins during development

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking.
Ye, Wenduo, Lin, Wenbo, Tartakoff, Alan M., Tao, Tao   +3 more
openaire   +3 more sources

Elucidation of the binding interaction interface between AAV serotype 11 capsid protein and host nuclear import proteins

Molecular Therapy: Methods & Clinical Development
Adeno-associated viruses (AAVs) are widely acknowledged as versatile vectors for gene therapy due to their non-pathogenic nature, inherent capacity for tissue-specific targeting, and their potential for customizable engineering. The N terminus of the AAV
Mikayla Hoad, Sepehr Nematollahzadeh, Justin A. Roby, Gualtiero Alvisi, Jade K. Forwood   +4 more
doaj   +1 more source

Karyopherin alpha subtypes and porcine early stage embryo development

, 2014
Intracellular communication between the nucleus and cytoplasm is critically important for coordinating cellular events during embryogenesis. The karyopherin α/β heterodimer is an intracellular nuclear trafficking system that mediates nuclear import of ...
Li, Yanfang
core  

Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.

PLoS ONE, 2011
The Karyopherin superfamily comprises nuclear transport proteins, involved in the shuttling of certain cargo proteins into and out of the nucleus. Karyopherin β1 (Kpnβ1) and Karyopherin α2 (Kpnα2) are importin proteins, which work in concert to transport
Pauline J van der Watt, Ellen Ngarande, Virna D Leaner   +2 more
doaj   +1 more source

Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins

, 2008
In eukaryotes, karyopherin beta superfamily proteins mediate nucleocytoplasmic transport of macromolecules. We investigated the evolutionary and transcriptional patterns of these proteins using bioinformatics approaches. No obvious homologs were found in
Ji, Z. L., Tao, T., 陶涛, Tartakoff, A. M., Quan, Y., Wang, X.   +5 more
core  

Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin β and Ran for nucleocytoplasmic trafficking

, 2010
The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor (OGFr) form an endogenous and tonically active growth-regulating system that modulates cell proliferation by upregulating the cyclin-dependent kinase inhibitory pathway.
Ian S Zagon, Patricia J McLaughlin, Fan Cheng   +2 more
core   +1 more source

IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation

Journal of Experimental & Clinical Cancer Research, 2019
Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng, Xuenong Li   +7 more
doaj   +1 more source