Results 81 to 90 of about 6,082 (161)

Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins

, 2008
In eukaryotes, karyopherin beta superfamily proteins mediate nucleocytoplasmic transport of macromolecules. We investigated the evolutionary and transcriptional patterns of these proteins using bioinformatics approaches. No obvious homologs were found in
Ji, Z. L., Tao, T., 陶涛, Tartakoff, A. M., Quan, Y., Wang, X.   +5 more
core  

Karyopherin alpha seven and porcine embryo development

, 2012
Coordinated partitioning of intracellular cargoes between nuclear and cytoplasmic compartments is critical for cell survival and differentiation. The karyopherin α/β heterodimer functions to import cytoplasmic proteins that possess classical nuclear ...
Wang, Xin
core   +1 more source

Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.

PLoS ONE, 2011
The Karyopherin superfamily comprises nuclear transport proteins, involved in the shuttling of certain cargo proteins into and out of the nucleus. Karyopherin β1 (Kpnβ1) and Karyopherin α2 (Kpnα2) are importin proteins, which work in concert to transport
Pauline J van der Watt, Ellen Ngarande, Virna D Leaner   +2 more
doaj   +1 more source

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α [PDF]

, 1998
Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin α recognizes “classical” monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa
Leighton, Lore, Conti, Elena, Blobel, Günter, Kuriyan, John, Uy, Marc   +4 more
core   +1 more source

IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation

Journal of Experimental & Clinical Cancer Research, 2019
Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng, Xuenong Li   +7 more
doaj   +1 more source

Karyopherin α deficiency contributes to human preimplantation embryo arrest

The Journal of Clinical Investigation, 2023
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang   +31 more
doaj   +1 more source

A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion

, 2008
Human karyopherin beta 3, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway.
Chung, Kyung Min, Cha, Sun-Shin, Jang, Sung Key   +2 more
core  

Karyopherin alphas in canonical nuclear import.

, 2017
(A) In canonical import, a karyopherin α (Kpna) binds to both the nuclear localization sequence-containing cargo protein and to Kpnb. Subsequently, Kpnb interacts with the nuclear pore to bring the trimeric complex into the nucleus.
Chi Zhang (9857), John N. Mariani (2805532), Setsu Sawai (508902), Benjamin M. Laitman (825245), Gareth R. John (825246)   +4 more
core   +1 more source

Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

, 2022
Supplementary Figure from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung ...
Trudy G. Oliver (14957133), Victor Stastny (421417), Rahul K. Kollipara, Trudy G. Oliver, Kyle B. Spainhower, Demetra P. Kelenis (14957115), Karine Pozo (14957121), Karine Pozo, Shreoshi Pal Choudhuri (14957124), Shreoshi Pal Choudhuri, Kathia E. Rodarte (14957118), Jane E. Johnson (14950788), Jane E. Johnson, Kyle B. Spainhower (14957127), Rahul K. Kollipara (14864973), Kathia E. Rodarte, Sarah J. Wait (14957130), Demetra P. Kelenis, Sarah J. Wait, Victor Stastny   +19 more
core   +1 more source

Nuclear Transport of Yeast Proteasomes

Biomolecules, 2014
Proteasomes are conserved protease complexes enriched in the nuclei of dividing yeast cells, a major site for protein degradation. If yeast cells do not proliferate and transit to quiescence, metabolic changes result in the dissociation of proteasomes ...
Cordula Enenkel
doaj   +1 more source