Results 81 to 90 of about 5,815 (206)
Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility
Asian Journal of Andrology, 2015 The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo +3 more
doaj +1 more source
Journal of Ovarian Research, 2021 Background Karyopherin α-2 (KPNA2) is a member of karyopherin family, which is proved to be responsible for the import or export of cargo proteins. Studies have determined that KPNA2 is associated with the development and prognosis of various cancers ...
Xiangrong Cui +4 more
doaj +1 more source
New insights into the regulation of cholesterol efflux from the sperm membrane
Asian Journal of Andrology, 2015 Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
doaj +1 more source
The Journal of Clinical Investigation, 2023 The genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this issue of the JCI, Wang, Miyamoto, et
Momal Sharif +2 more
doaj +1 more source
, 2002 peer reviewedThe activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands.
Braem, Caroline V +11 more
core +1 more source
A 3D Physical Model of Karyopherin‐β2
The FASEB Journal, 2012 Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong +12 more
openaire +1 more source
Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. [PDF]
Proceedings of the National Academy of Sciences, 1995 Previously, we had purified a cytosolic protein complex, termed karyopherin, that functions in docking import substrate at the nuclear envelope in digitonin-permeabilized cells and also had molecularly cloned and sequenced its 97-kDa beta subunit. We now report that the karyopherin alpha subunit is the previously identified protein NPI-1/SRP-1 of ...
J, Moroianu, G, Blobel, A, Radu
openaire +2 more sources
Nuclear Transport of Yeast Proteasomes
Frontiers in Molecular Biosciences, 2019 Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP).
Petra Wendler, Cordula Enenkel
doaj +1 more source
Structural Insights Into the Nuclear Import of Marek’s Disease Virus Large Tegument Protein
Advances in Virology, Volume 2026, Issue 1, 2026.Marek’s disease (MD) is a highly contagious neoplastic disorder of poultry caused by MD virus (MDV; gallid alphaherpesvirus 2 [GaAHV2]). Infection results in profound immunosuppression, neurological dysfunction, and the development of malignant T‐cell lymphomas.
Babu Kanti Nath +7 more
wiley +1 more source
, 2000 Karyopherin-beta 3 is a nuclear transport receptor that appears to be involved in nuclear import of ribosomal proteins. Here we report on sequence and expression of karyopherin-beta 3 in Xenopus.
Chen, Y. L. +4 more
core +1 more source