Results 81 to 90 of about 9,891 (213)

Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

Asian Journal of Andrology, 2015
This chapter explores the possibility that capacitation and apoptosis are linked processes joined by their common dependence on the continued generation of reactive oxygen species (ROS).
Robert J Aitken, Mark A Baker, Brett Nixon   +2 more
doaj   +1 more source

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]

, 2010
In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza, Auer, Manfred, Bednenko, Janna, Gerace, Larry, Gstach, Hubert, Hintersteiner, Martin, Knox, Andrew J. S., Meisner, Nicole-Claudia, Schmied, Mario, Seifert, Jan-Marcus, Singer, Eric L.   +10 more
core   +1 more source

Epstein–Barr Virus Nuclear Antigen-1 Binds to Nuclear Transporter Karyopherin α1/NPI-1 in Addition to Karyopherin α2/Rch1

Virology, 2000
We searched for cellular proteins that interact with Epstein-Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast two-hybrid screening of a B lymphocyte cDNA library in this study.
Ito, Sayuri, Ikeda, Masato, Kato, Noriko, Matsumoto, Akiko, Ishikawa, Yuko, Kumakubo, Satomi, Yanagi, Kazuo   +6 more
openaire   +2 more sources

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, Volume 5, Issue 11, November 2025.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

Asian Journal of Andrology, 2015
Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF ...
Carol Coughlan, Helen Clarke, Rachel Cutting, Jane Saxton, Sarah Waite, William Ledger, Tinchiu Li, Allan A Pacey   +7 more
doaj   +1 more source

The Role of TNPO3 in HIV-1 Replication [PDF]

, 2012
TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin β superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction ...
Felipe Diaz-Griffero
core   +2 more sources

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Functional consequences of necdin nucleocytoplasmic localization. [PDF]

PLoS ONE, 2012
BACKGROUND: Necdin, a MAGE family protein expressed primarily in the nervous system, has been shown to interact with both nuclear and cytoplasmic proteins, but the mechanism of its nucleocytoplasmic transport are unknown.
Anat Lavi-Itzkovitz, Marianna Tcherpakov, Zehava Levy, Shalev Itzkovitz, Francoise Muscatelli, Mike Fainzilber   +5 more
doaj   +1 more source

Karyopherin β2B participates in mRNA export from the nucleus [PDF]

Proceedings of the National Academy of Sciences, 2002
Transport of macromolecules between the cell nucleus and cytoplasm occurs through the nuclear pores and is mediated by soluble carriers known as karyopherins (Kaps), transportins, importins, or exportins. We report that Kap β2B (transportin-2) forms complexes with the mRNA export factor TAP in the presence of RanGTP, as shown by ...
Monee K, Shamsher, Jonathan, Ploski, Aurelian, Radu   +2 more
openaire   +2 more sources

Computational Analysis of Exosome‐Derived Signature in TNBC: Integrating Single‐Cell and Bulk Transcriptomics for Prognosis Prediction

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Triple‐negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited targeted therapeutic options. Exosomes, small membrane vesicles secreted by cells, play a crucial role in intercellular communication and material exchange. However, the role of exosome‐related genes (ERGs) in TNBC remains unclear.
Yuan Zhang, Ming Zhao, Lei Hou, Long Jin, Jun Bai, Yunzhi Dang   +5 more
wiley   +1 more source