Results 141 to 150 of about 6,082 (161)

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins. [PDF]

Bioessays
Bernardes N, Chook YM.
europepmc   +1 more source

Karyopherin abnormalities in neurodegenerative proteinopathies

Brain, 2021
Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation.
Tibor Hortobágyi, Frank Hirth, Terouz Pasha   +2 more
exaly   +2 more sources

Nuclear import by karyopherin-βs: Recognition and inhibition [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research, 2011
Proteins in the karyopherin-β family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of the 14S.
Yuh Min Chook
exaly   +2 more sources

X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking

Journal of Molecular Biology, 2020
International audienceHere, we describe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP5 and investigate its global propensity to interact with influenza A virus polymerase.
Imre Berger, Bernard Delmas, Rob W H Ruigrok   +2 more
exaly   +2 more sources

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin α [PDF]

Structure, 2000
Background: Karyopherin α (importin α) is an adaptor molecule that recognizes proteins containing nuclear localization signals (NLSs). The prototypical NLS that is able to bind to karyopherin α is that of the SV40 T antigen, and consists of a short ...
John Kuriyan
exaly   +2 more sources

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A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders

Structure, 2023
Chad A Brautigam, Ho Yee Joyce Fung, Yuh Min Chook   +2 more
exaly  

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

International Journal of Cancer, 2009
Michael J Birrer, Lynette Denny, Virna D Leaner   +2 more
exaly  

A Novel Function of Karyopherin β3 Associated with Apolipoprotein A-I Secretion

Molecules and Cells, 2008
Min Kyung Chung, Sung Key Jang, Sun-Shin Cha   +2 more
exaly  

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

Cancer Letters, 2013
Lars Dyrskjøt
exaly  

Cloning and characterization of homologs of nuclear import factors, karyopherin α and karyopherin β

Molecular and Biochemical Parasitology, 2003
Virander Singh Chauhan, Asif Mohmmed, Pawan Malhotra   +2 more
exaly