Results 21 to 30 of about 5,140 (176)
Cloning and characterization of human karyopherin β3 [PDF]
Proceedings of the National Academy of Sciences, 1997 Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin α/β1 heterodimers. A second nuclear import pathway, mediated by karyopherin β2 (transportin), recently was described for mRNA-binding proteins. Here we report the cloning and characterization of human karyopherin β3, which may be involved in a third ...
N R, Yaseen, G, Blobel
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Tumor Biology, 2017 This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 ...
Long Huang +6 more
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A karyopherin acts in localized protein synthesis [PDF]
Cell Cycle, 2010 Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and mRNA targeting.
Veenhoff, Liesbeth M. +2 more
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eLife, 2019 Intracellular Wolbachia bacteria manipulate arthropod reproduction to promote their own inheritance. The most prevalent mechanism, cytoplasmic incompatibility (CI), traces to a Wolbachia deubiquitylase, CidB, and CidA.
John Frederick Beckmann +4 more
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Birth, Death, and Replacement of Karyopherins in Drosophila [PDF]
Molecular Biology and Evolution, 2011 Nucleocytoplasmic transport is a broadly conserved process across eukaryotes. Despite its essential function and conserved mechanism, components of the nuclear transport apparatus have been implicated in genetic conflicts in Drosophila, especially in the male germ line. The best understood case is represented by a truncated RanGAP gene duplication that
Nitin, Phadnis +2 more
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Exploring the role of mononuclear phagocytes in the epididymis
Asian Journal of Andrology, 2015 The onslaught of foreign antigens carried by spermatozoa into the epididymis, an organ that has not demonstrated immune privilege, a decade or more after the establishment of central immune tolerance presents a unique biological challenge.
Nicolas Da Silva, Tegan B Smith
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Karyopherins in nuclear pore biogenesis [PDF]
The Journal of Cell Biology, 2002 The mechanisms that govern the assembly of nuclear pore complexes (NPCs) remain largely unknown. Here, we have established a role for karyopherins in this process. We show that the yeast karyopherin Kap121p functions in the targeting and assembly of the nucleoporin Nup53p into NPCs by recognizing a nuclear localization signal (NLS) in Nup53p.
C. Patrick Lusk +4 more
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Frontiers in Molecular Neuroscience, 2018 The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins.
Gerry Nganou +17 more
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Asian Journal of Andrology, 2015 Biomarker-based sperm analysis elevates the treatment of human infertility and ameliorates reproductive performance in livestock. The negative biomarker-based approach focuses on proteins and ligands unique to defective spermatozoa, regardless of their ...
Peter Sutovsky +3 more
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Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
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