Results 11 to 20 of about 5,815 (206)

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation. [PDF]

PLoS ONE, 2017
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair.
Benjamin M Laitman, John N Mariani, Chi Zhang, Setsu Sawai, Gareth R John   +4 more
doaj   +5 more sources

KPNB1 (karyopherin (importin) beta 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is ...
Leaner, V, Lavia, P, Giubettini, M, van, der Watt P, Verrico, A, de, Turris V   +5 more
core   +4 more sources

A karyopherin acts in localized protein synthesis [PDF]

Cell Cycle, 2010
Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules.
Veenhoff, Liesbeth M.,, Poolman, Bert,, Meinema, Anne C.,, Veenhoff, Liesbeth M.; id_orcid, Meinema, Anne C., Anne C. Meinema, Bert Poolman, Liesbeth M. Veenhoff, Veenhoff, Liesbeth M., Poolman, Bert   +9 more
core   +4 more sources

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. [PDF]

PLoS ONE, 2012
BackgroundProtein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells are either bacterial pathogenic toxins or endogenous ...
Simone Di Paola, Massimo Micaroni, Giuseppe Di Tullio, Roberto Buccione, Maria Di Girolamo   +4 more
doaj   +2 more sources

Epstein–Barr Virus Nuclear Antigen-1 Binds to Nuclear Transporter Karyopherin α1/NPI-1 in Addition to Karyopherin α2/Rch1

Virology, 2000
We searched for cellular proteins that interact with Epstein–Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast ...
Ishikawa, Yuko, Ikeda, Masato, Yanagi, Kazuo, Kato, Noriko, Ito, Sayuri, Matsumoto, Akiko, Kumakubo, Satomi   +6 more
core   +3 more sources

The dynamics of karyopherin-mediated nuclear transport

Biochemistry and Cell Biology, 2001
The regulated exchange of proteins and nucleic acids between the nucleus and cytoplasm demands a complex interplay between nuclear pore complexes (NPCs), which provide conduits in the nuclear envelope, and mobile transport receptors (or karyopherins ...
David J Dilworth, Richard W Wozniak, John D Aitchison, Marcello Marelli   +3 more
core   +3 more sources

Multi-omics analysis identifies a major histocompatibility complex class II-associated antigen-presenting cancer-associated fibroblast-like state linked to the nuclear factor erythroid 2-related factor 2-karyopherin subunit beta 1 axis in nonsmall cell lung cancer. [PDF]

J Cell Commun Signal
NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Zheng F, Deng R, Hou R, Hong L, Cui Y, Liu Y.   +5 more
europepmc   +2 more sources

Yeast karyopherin Kap95 is required for cell cycle progression at Start [PDF]

BMC Cell Biology, 2010
Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual, Juan Carlos, Francisco Taberner, Igual Juan, Taberner Francisco, Juan Igual, Juan Carlos Igual, Taberner Sanchis, Francisco José, Taberner, Francisco J, Igual García, Juan Carlos, Francisco José Taberner   +9 more
core   +6 more sources

Karyopherins and condensates

Current Opinion in Cell Biology, 2020
Several aggregation-prone RNA-binding proteins, including FUS, EWS, TAF15, hnRNP A1, hnRNP A2, and TDP-43, are mutated in neurodegenerative diseases. The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these
Charis E. Springhower, Michael K. Rosen, Yuh Min Chook   +2 more
openaire   +2 more sources

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: A novel path to cancer prevention. [PDF]

Int J Cancer
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Hajirahimkhan A, Bartom ET, Chung CH, Guo X, Berkley K, Hosseinibarkooie S, Assadi Z, Weng SHS, Moellering R, Lee O, Chen R, Cho W, Chandrasekaran S, Clare SE, Khan SA.   +14 more
europepmc   +2 more sources