Results 11 to 20 of about 9,891 (213)

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation. [PDF]

PLoS ONE, 2017
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair.
Benjamin M Laitman, John N Mariani, Chi Zhang, Setsu Sawai, Gareth R John   +4 more
doaj   +4 more sources

The HIV capsid mimics karyopherin engagement of FG-nucleoporins [PDF]

Nature
AbstractHIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central
Claire Dickson, Sophie Hertel, Nan Li
exaly   +5 more sources

Karyopherins regulate nuclear pore complex barrier and transport function [PDF]

Journal of Cell Biology, 2017
Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Adam, Allen, Bayliss, Bednenko, Ben-Efraim, Binlu Huang, Bischoff, Catimel, Chaillan-Huntington, Chantal Rencurel, Chook, Christie, Cingolani, Cingolani, Conti, Delphin, Eibauer, Eisele, Falces, Floer, Forwood, Forwood, Frey, Fukuhara, Grünwald, Görlich, Görlich, Görlich, Görlich, Hahn, Halder, Hough, Isgro, Kapinos, Kau, Kimura, Kopito, Kubitscheck, Kutay, Kutay, Larisa E. Kapinos, Lee, Lee, Lim, Lim, Lolodi, Lonhienne, Lowe, Lyman, Makise, Milles, Moroianu, Moroianu, Nigg, Ogawa, Paradise, Popken, Pumroy, Pyhtila, Rexach, Ribbeck, Riddick, Roderick Y.H. Lim, Rout, Sakiyama, Schoch, Stewart, Strawn, Sun, Tauchert, Timney, Tokunaga, Tu, von Appen, Vovk, Wagner, Weis, Yamada, Yang, Yang, Yoshimura, Zachariae   +81 more
core   +6 more sources

Karyopherin α deficiency contributes to human preimplantation embryo arrest

The Journal of Clinical Investigation, 2023
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang   +31 more
doaj   +3 more sources

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: A novel path to cancer prevention. [PDF]

Int J Cancer
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Hajirahimkhan A, Bartom ET, Chung CH, Guo X, Berkley K, Hosseinibarkooie S, Assadi Z, Weng SHS, Moellering R, Lee O, Chen R, Cho W, Chandrasekaran S, Clare SE, Khan SA.   +14 more
europepmc   +2 more sources

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins. [PDF]

Bioessays
Efficient nuclear import of histones requires coordinated action between histone chaperones and nuclear import receptors. Importin‐4, Importin‐9, and Importin‐β/7 not only transport specific histone complexes but also act as chaperones, stabilizing histones and ensuring their protected delivery for nucleosome assembly, highlighting importins as central
Bernardes N, Chook YM.
europepmc   +2 more sources

Karyopherins and condensates

Current Opinion in Cell Biology, 2020
Several aggregation-prone RNA-binding proteins, including FUS, EWS, TAF15, hnRNP A1, hnRNP A2, and TDP-43, are mutated in neurodegenerative diseases. The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these
Charis E. Springhower, Michael K. Rosen, Yuh Min Chook   +2 more
openaire   +2 more sources

Kapβ2 Reverses Sevoflurane-Induced Hydrogel Phase Transition of hnRNPA2/B1-SG in Hypoxic Primary Rat Hippocampal Neurons. [PDF]

CNS Neurosci Ther
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Zhang M, Wang X, Jia F, Yang C, Wang Z, Liao H, Zhang L, Xin X, Wang H.   +8 more
europepmc   +2 more sources

Karyopherins in nuclear pore biogenesis [PDF]

The Journal of Cell Biology, 2002
The mechanisms that govern the assembly of nuclear pore complexes (NPCs) remain largely unknown. Here, we have established a role for karyopherins in this process. We show that the yeast karyopherin Kap121p functions in the targeting and assembly of the nucleoporin Nup53p into NPCs by recognizing a nuclear localization signal (NLS) in Nup53p.
C. Patrick Lusk, Taras Makhnevych, Marcello Marelli, John D. Aitchison, Richard W. Wozniak   +4 more
openaire   +1 more source

KPNB1 (karyopherin (importin) beta 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on KPNB1 (karyopherin (importin) beta 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Maria Giubettini, Pauline van der Watt, Annalisa Verrico, Valeria de Turris, Virna Leaner, Patrizia Lavia   +5 more
openaire   +3 more sources