Results 11 to 20 of about 5,140 (176)
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation. [PDF]
PLoS ONE, 2017 Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair.
Benjamin M Laitman +4 more
doaj +4 more sources
Multi-omics analysis identifies a major histocompatibility complex class II-associated antigen-presenting cancer-associated fibroblast-like state linked to the nuclear factor erythroid 2-related factor 2-karyopherin subunit beta 1 axis in nonsmall cell lung cancer. [PDF]
J Cell Commun SignalNSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Zheng F +5 more
europepmc +2 more sources
Karyopherin α deficiency contributes to human preimplantation embryo arrest
The Journal of Clinical Investigation, 2023 Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang +31 more
doaj +3 more sources
Current Opinion in Cell Biology, 2020 Several aggregation-prone RNA-binding proteins, including FUS, EWS, TAF15, hnRNP A1, hnRNP A2, and TDP-43, are mutated in neurodegenerative diseases. The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these
Charis E. Springhower +2 more
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A Role for the Karyopherin Kap123p in Microtubule Stability [PDF]
Traffic, 2009 Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule‐destabilizing drugs.
Christopher, Ptak +7 more
openaire +2 more sources
The role of karyopherins in the regulated sumoylation of septins [PDF]
The Journal of Cell Biology, 2007 In the yeast Saccharomyces cerevisiae, several components of the septin ring are sumoylated during anaphase and then abruptly desumoylated at cytokinesis. We show that septin sumoylation is controlled by the interactions of two enzymes of the sumoylation pathway, Siz1p and Ulp1p, with the nuclear transport machinery.
Makhnevych, Taras +4 more
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Current Opinion in Cell Biology, 2018 Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells.
Tolga Çağatay, Yuh Min Chook
openaire +3 more sources
Modulation of Histone Deposition by the Karyopherin Kap114 [PDF]
Molecular and Cellular Biology, 2005 The nuclear import of histones is a prerequisite for the downstream deposition of histones to form chromatin. However, the coordinate regulation of these processes remains poorly understood. Here we demonstrate that Kap114p, the primary karyopherin/importin responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones
Nima, Mosammaparast +2 more
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The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence. [PDF]
Proceedings of the National Academy of Sciences, 1996 By using proteolysis, recombinant mutant proteins, or synthetic peptides and by testing these reagents in liquid phase binding or nuclear import assays, we have mapped binding regions of karyopherin alpha. We found that the C-terminal region of karyopherin alpha recognizes the nuclear localization sequence (NLS), whereas its N-terminal region binds ...
J, Moroianu, G, Blobel, A, Radu
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Oncology, 2022 <b><i>Introduction:</i></b> Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. Although high KPNA2 expression was associated with poor prognosis in solid tumors, the relationship between KPNA2 and KPNB1 ...
Yoshihito Ohhara +10 more
openaire +2 more sources