Results 31 to 40 of about 6,082 (161)

The paternal genome and the health of the assisted reproductive technology child

open access: yesAsian Journal of Andrology, 2015
As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern.
Sheena EM Lewis, Kishlay Kumar
doaj   +1 more source

Redox regulation of mammalian sperm capacitation

open access: yesAsian Journal of Andrology, 2015
Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species (ROS) that will ...
Cristian O′Flaherty
doaj   +1 more source

Epstein–Barr Virus Nuclear Antigen-1 Binds to Nuclear Transporter Karyopherin α1/NPI-1 in Addition to Karyopherin α2/Rch1 [PDF]

open access: yes, 2000
We searched for cellular proteins that interact with Epstein–Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast ...
Ishikawa, Yuko   +6 more
core   +1 more source

Behavioral mechanisms of mammalian sperm guidance

open access: yesAsian Journal of Andrology, 2015
In mammals, sperm guidance in the oviduct appears essential for successful sperm arrival at the oocyte. Hitherto, three different potential sperm guidance mechanisms have been recognized: thermotaxis, rheotaxis, and chemotaxis, each of them using ...
Serafín Pérez Cerezales   +2 more
doaj   +1 more source

ROS-mediated DJ-1 monomerization modulates intracellular trafficking involving Karyopherin-2

open access: yes, 2014
Mutations in DJ-1 are a cause of recessive, early-onset Parkinson's disease (PD). Although oxidative stress and mitochondrial integrity have been implicated in PD, it is largely unknown why neurons degenerate.
Larsen, J.P.   +11 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition

open access: yesAsian Journal of Andrology, 2015
One of the most common lesions present in the spermatozoa of human infertility patients is an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can now be readily by-passed by assisted reproductive strategies such as ...
Brett Nixon   +5 more
doaj   +1 more source

Microarray Analysis of Gene Expression in Saccharomyces cerevisiae kap108Δ Mutants upon Addition of Oxidative Stress

open access: yesG3: Genes, Genomes, Genetics, 2016
Protein transport between the nucleus and cytoplasm of eukaryotic cells is tightly regulated, providing a mechanism for controlling intracellular localization of proteins, and regulating gene expression. In this study, we have investigated the importance
Kenneth D. Belanger   +4 more
doaj   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang   +5 more
wiley   +1 more source

A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population

open access: yesAsian Journal of Andrology, 2015
A natural disaster leading to accumulation of environmental contaminants may have substantial effects on the male reproductive system. Our aim was to compare and assess semen parameters in a normospermic population residing in the Southern Louisiana, USA
Caner Baran   +2 more
doaj   +1 more source

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