A Novel Class of RanGTP Binding Proteins [PDF]
Journal of Cell Biology, 1997 The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implicated also in a variety of other processes, such as cell cycle progression, a direct function ...
Dirk Görlich +2 more
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Microtubule Nucleation in Mitosis by a RanGTP-Dependent Protein Complex [PDF]
Current Biology, 2015 SummaryBackgroundThe γ-tubulin ring complex (γTuRC) is a multisubunit complex responsible for microtubule (MT) nucleation in eukaryotic cells. During mitosis, its spatial and temporal regulation promotes MT nucleation through different pathways.
TERESA Sardón +2 more
exaly +4 more sources
Motorless transport of microtubules along tubulin, RanGTP, and salt gradients. [PDF]
Nat CommunMicrotubules are dynamic filaments that assemble spindles for eukaryotic cell division. As the concentration profiles of soluble tubulin and regulatory proteins are non-uniform during spindle assembly, we asked if diffusiophoresis - motion of particles ...
Shim S +5 more
europepmc +7 more sources
The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond [PDF]
Frontiers in Cell and Developmental Biology, 2016 The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors ...
Tommaso Cavazza +2 more
exaly +7 more sources
Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation [PDF]
Journal of Cell Biology, 2011 Regulated spindle orientation maintains epithelial tissue integrity and stem cell asymmetric cell division. In Drosophila melanogaster neural stem cells (neuroblasts), the scaffolding protein Canoe (Afadin/Af-6 in mammals) regulates spindle orientation ...
Christopher A Johnston +2 more
exaly +4 more sources
RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors
FEBS Letters, 1997 Nucleocytoplasmic transport appears mediated by shuttling transport receptors that bind RanGTP as a means to regulate interactions with their cargoes. The receptor·RanGTP complexes are kinetically very stable with nucleotide exchange and GTP hydrolysis ...
F R Bischoff, Dirk Görlich
exaly +2 more sources
Understanding RanGTP dependent microtubule assembly : Idenification of DnaJB6 as a RanGTP regulated factor involved in microtubule organization during mitosis [PDF]
, 2017 Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the spindle, all these MTs are organized
Rosas Salvans, Miquel
core +3 more sources
Mechanism of RanGTP dependent microtubule assembly during mitosis [PDF]
, 2014 During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly ...
Scrofani, Jacopo
core +3 more sources
Branched microtubule nucleation and dynein transport organize RanGTP asters in Xenopus laevis egg extract. [PDF]
Mol Biol CellChromosome segregation relies on the correct assembly of a bipolar spindle. Spindle pole self-organization requires dynein-dependent microtubule (MT) transport along other MTs.
Scrofani J +6 more
europepmc +2 more sources
Role of RanGTP and spindle assembly factors in cilia assembly and function [PDF]
, 2021 El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor.
Mòdol Cano, Aitor
core +1 more source